02563nas a2200265   4500008004100000022001400041245013200055210006900187260000900256300001000265490000700275520167700282653001801959653001501977653002201992653002702014653001302041100002202054700002102076700001602097700002402113700001702137700002202154856012102176       2015                        eng d  a0920-506300aFluorescent cadmium telluride quantum dots embedded chitosan nanoparticles: a stable, biocompatible preparation for bio-imaging0 aFluorescent cadmium telluride quantum dots embedded chitosan nan  cJAN   a42-560 v263 a<p>Fluorescent cadmium telluride quantum dots (CdTe QDs) are an optically attractive option for bioimaging, but are known to display high cytotoxicity. Nanoparticles synthesized from chitosan, a natural biopolymer of beta 1-4 linked glucosamine, display good biocompatibility and cellular uptake. A facile, green synthetic strategy has been developed to embed green fluorescent cadmium telluride quantum dots (CdTe QDs) in biocompatible CNPs to obtain a safer preparation than `as is' QDs. High-resolution transmission electron microscopy showed the crystal lattice corresponding to CdTe QDs embedded in CNPs while thermogravimetry confirmed their polymeric composition. Electrostatic interactions between thiol-capped QDs (4nm, -57mV) and CNPs (\~300nm, +38mV) generated CdTe QDs-embedded CNPs that were stable up to three months. Further, viability of NIH3T3 mouse fibroblast cells in vitro increased in presence of QDs-embedded CNPs as compared to bare QDs. At the highest concentration (10 mu g/ml), the former shows 34 and 39% increase in viability at 24 and 48h, respectively, as compared to the latter. This shows that chitosan nanoparticles do not release the QDs up to 48h and do not cause extended toxicity. Furthermore, hydrolytic enzymes such as lysozyme and chitinase did not degrade chitosan nanoparticles. Moreover, QDs-embedded CNPs show enhanced internalization in NIH3T3 cells as compared to bare QDs. This method offers ease of synthesis and handling of stable, luminescent, biocompatible CdTe QDs-embedded CNPs with a favorable toxicity profile and better cellular uptake with potential for bioimaging and targeted detection of cellular components.</p>10aBiocompatible10abioimaging10aCdTe quantum dots10achitosan nanoparticles10aToxicity1 aGhormade, Vandana1 aGholap, Haribhau1 aKale, Sonia1 aKulkarni, Vaishnavi1 aBhat, Suresh1 aPaknikar, Kishore  uhttps://library.ncl.res.in/content/fluorescent-cadmium-telluride-quantum-dots-embedded-chitosan-nanoparticles-stable02322nas a2200241   4500008004100000022001400041245014000055210006900195260000800264300001100272490000700283520143600290653002701726653002901753653002001782653002301802653002701825653002701852100001801879700002801897700002701925856012801952       2020                        eng d  a1773-224700aUnderstanding fundamentals of hepatocellular carcinoma to design next-generation chitosan nano-formulations: Beyond chemotherapy stride0 aUnderstanding fundamentals of hepatocellular carcinoma to design  cAUG  a1017230 v583 a<p>Hepatocellular carcinoma (HCC) is the deadliest form of liver cancer. Clinically, the main strategies currently being used for the treatment of HCC are surgery, radiotherapy and chemotherapy. Conventional chemotherapy has major drawbacks such as poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, and non-specific drug targeting. Therefore, targeted drug delivery systems are fast becoming new tools for the selective killing of cancer cells. Chitosan (CS) is a biodegradable, biocompatible, cationic and natural biopolymer that also exhibits anti-cancer property which is now being explored as a promising candidate for targeted drug delivery. This review outlines an overview of the causative agents, microenvironment, pathophysiology, surface-biomarkers and physiological barriers of HCC. Then, the cellular internalization pathways of nanomedicine and the important physicochemical properties of delivery agents are discussed. The benefits of targeted therapy over conventional therapy with regard to HCC are also discussed. The main objective of this review was to summarize the current knowledge in the field of chitosan-based drug delivery for the management of HCC along with its limitations in a comprehensive and systematic way. This review attempts to provide a holistic roadmap for designing the next-generation chitosan-based drug delivery systems for HCC management.</p>
10achitosan nanoparticles10aHepatocellular carcinoma10aPathophysiology10aSurface biomarkers10aTargeted Drug Delivery10aTumor microenvironment1 aJaiswal, Neha1 aChaudhari, Ravindra, D.1 aChaudhari, Bhushan, P.  uhttps://library.ncl.res.in/content/understanding-fundamentals-hepatocellular-carcinoma-design-next-generation-chitosan-nano