01362nas a2200205   4500008004100000022001400041245012300055210006900178260000800247300001400255490000700269520063700276653001700913653001700930653002500947653001300972100001700985700002601002856012801028       2017                        eng d  a0040-402000aCritical role of select peptides in the loop region of G-rich PNA in the preferred G-quadruplex topology and stability0 aCritical role of select peptides in the loop region of Grich PNA  cMAR  a1534-15400 v733 a<p>An uncharged PNA 15mer sequence formed unimolecular antiparallel G-quadruplex similar to that observed for DNA-TBA. Replacement of `tt' loop regions by peptides which induce helices or turns were found to have unpresidented effect on the quadruplex topology and stability. This study opens up a completely new strategy of utilizing G-quadruplex formation to display the array of functional groups in the three dimensional space thus creating a possibility of getting closer to the dream of designed peptides with three dimensional structures as observed in catalytic protein folds. (C) 2017 Elsevier Ltd. All rights reserved.</p>10aESI-MS study10aG-quadruplex10aPeptide nucleic acid10atopology1 aBose, Tanaya1 aKumar, Vaijayanti, A.  uhttps://library.ncl.res.in/content/critical-role-select-peptides-loop-region-g-rich-pna-preferred-g-quadruplex-topology-and01859nas a2200229   4500008004100000022001400041245008700055210006900142260000900211300001600220490000600236520110900242653002001351653001201371653002101383653002501404653001801429100002301447700002101470700002401491856011401515       2019                        eng d  a2365-654900aSelf-assembly of Di-guanine peptide nucleic acid amphiphiles into fractal patterns0 aSelfassembly of Diguanine peptide nucleic acid amphiphiles into   cDEC   a13525-135320 v43 a<p>Peptide nucleic acids (PNAs) amphiphiles have been reported to assemble into different nanostructures; however, there is immense untapped potential to control their supramolecular assemblies by altering their lipid chain. Here, we functionalized di-guanine PNA with various hydrophobic appendages, namely dodecyl, p-dodecylbenzoyl and pentadecyl phenol groups, to investigate the effect of aromatic linkers, long alkyl and alkoxyl substituents on hierarchical self-assembly of di-guanine PNA. Systematic electron microscopy and atomic force microscopy studies revealed that while all three derivatives of di-guanine-PNA formed nanospheres, only nanospheres of dodecylamide and pentadecyl phenol derivatives matured into nanorods, these later formed higher order fractal assemblies. Furthermore, we observed that inclusion of a positively charged lysine at the C-terminus prevented fractal assembly, possibly due to electrostatic repulsion between the head groups. Thus, the findings of the present work might guide rational design of PNA amphiphiles to obtain specific self-assembled morphology.</p>
10aFractal pattern10aGuanine10apentadecylphenol10aPeptide nucleic acid10aSelf-assembly1 aAbraham, Jancy, N.1 aPawar, Prabhakar1 aKootteri, Dilna, K.  uhttps://library.ncl.res.in/content/self-assembly-di-guanine-peptide-nucleic-acid-amphiphiles-fractal-patterns