01598nas a2200205   4500008004100000022001400041245011200055210006900167260000800236300001100244490000600255520088300261653001301144653001801157653002101175653001701196100002201213700002501235856013201260       2018                        eng d  a2054-570300aPhotophysical studies on curcumin-sophorolipid nanostructures: applications in quorum quenching and imaging0 aPhotophysical studies on curcuminsophorolipid nanostructures app  cFEB  a1708650 v53 a<p>Sophorolipid biosurfactants are biodegradable, less toxic and FDA approved. The purified acidic form of sophorolipid is stimuli-responsive with self-assembling properties and used for solubilizing hydrophobic drugs. This study encapsulated curcumin (CU) with acidic sophorolipid (ASL) micelles and analysed using photophysical studies like UV-visible spectroscopy, photoluminescence (PL) spectroscopy and timecorrelated single photon counting (TCSPC). TEM images have revealed ellipsoid micelles of approximately 100nm size and were confirmed by dynamic light scattering. The bacterial fluorescence uptake studies showed the uptake of formed CUASL nanostructures into both Gram-positive and Gram-negative bacteria. They also showed quorum quenching activity against Pseudomonas aeruginosa. The results have demonstrated this system has potential theranostic applications.</p>10acurcumin10aphotophysical10aQuorum quenching10aSophorolipid1 aVasudevan, Sahana1 aPrabhune, Asmita, A.  uhttps://library.ncl.res.in/content/photophysical-studies-curcumin-sophorolipid-nanostructures-applications-quorum-quenching-and02223nas a2200289   4500008004100000245012600041210006900167260000800236300000900244490000700253520117200260653001301432653001301445653002001458653002101478653002601499653002601525100003801551700004201589700002301631700002801654700002701682700002701709700003701736700003401773856012601807       2020                        eng d00aBacterial biofilm formation using PCL/curcumin electrospun fibers and its potential use for biotechnological applications0 aBacterial biofilm formation using PCLcurcumin electrospun fibers  cDEC  a55560 v133 a<p>Electrospun nanofibers are used for many applications due to their large surface area, mechanical properties, and bioactivity. Bacterial biofilms are the cause of numerous problems in biomedical devices and in the food industry. On the other hand, these bacterial biofilms can produce interesting metabolites. Hence, the objective of this study is to evaluate the efficiency of poly (x190;- caprolactone)/Curcumin (PCL/CUR) nanofibers to promote bacterial biofilm formation. These scaffolds were characterized by scanning electron microscopy (SEM), which showed homogeneous fibers with diameters between 441-557 nm; thermogravimetric analysis and differential scanning calorimetry (TGA and DSC) demonstrated high temperature resilience with degradation temperatures over &gt;350 degrees C; FTIR and H-1-NMR serve as evidence of CUR incorporation in the PCL fibers. PCL/CUR scaffolds successfully promoted the formation of Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa biofilms. These results will be valuable in the study of controlled harvesting of pathogenic biofilms as well as in metabolites production for biotechnological purposes.</p>
10aBacteria10acurcumin10aelectrospinning10aEscherichia coli10aPseudomona aeruginosa10aStaphylococcus aureus1 aPompa-Monroy, Daniella, Alejandra1 aFigueroa-Marchant, Paulina, Guadalupe1 aDastager, Syed, G.1 aThorat, Meghana, Namdeo1 aIglesias, Ana, Leticia1 aMiranda-Soto, Valentin1 aPerez-Gonzalez, Graciela, Lizeth1 aVillarreal-Gomez, Luis, Jesus  uhttps://library.ncl.res.in/content/bacterial-biofilm-formation-using-pclcurcumin-electrospun-fibers-and-its-potential-use02227nas a2200253   4500008004100000022001400041245012500055210006900180260000800249300001100257490000800268520135000276653001501626653002201641653001301663653002001676653002201696653003501718100002501753700002101778700002601799700002201825856012601847       2021                        eng d  a0255-270100aUltrasound assisted curcumin recovery from Curcuma aromatica: understanding the effect of different operating parameters0 aUltrasound assisted curcumin recovery from Curcuma aromatica und  cDEC  a1086040 v1693 aThe present study deals with intensified extraction of curcumin from Curcuma aromatica by employing ultrasound-assisted extraction (UAE) approach also elucidating comparison with the conventional batch extraction to highlight the intensification benefits based on the usage of ultrasound. Understanding into the effect of operational parameters like type of solvent, extraction temperature, solid to solvent ratio and raw material size distribution as well as the equipment operating conditions as frequency and power on the extraction yield has been developed. Based on the results for extraction yield, the optimum conditions for UAE approach were 40 degrees C as temperature, 1:30 as solid to solvent ratio, 0.09 mm as the mean particle size, 240 W as ultrasonic power, 22 kHz as ultrasonic frequency and ethanol as the most suitable solvent. Under these optimum conditions, the highest extraction yield of 73.18% was achieved in 2 h whereas batch extraction for 14 h resulted in 52.31% yield clearly demonstrating the intensification due to ultrasound. Peleg's model was applied to explain the extraction kinetics of curcumin and the proposed model satisfactorily predicted the rates of extraction of cur cumin. Overall, UAE proved to be a better technique in terms of lesser time, lesser heating requirement and additional extraction yield.10aCavitation10aCurcuma aromatica10acurcumin10aIntensification10aKinetic modelling10aUltrasound assisted extraction1 aShirsath, Sachin, R.1 aSable, Sunil, S.1 aGaikwad, Shashank, G.1 aGogate, Parag, R.  uhttps://library.ncl.res.in/content/ultrasound-assisted-curcumin-recovery-curcuma-aromatica-understanding-effect-different02661nas a2200241   4500008004100000022001400041245013400055210006900189260000800258300001100266490000700277520181500284653001902099653001302118653001502131653002302146653001802169100002902187700002102216700001902237700003402256856012902290       2022                        eng d  a1773-224700aBioinspired hyaluronic acid based nanofibers immobilized with 3, 4-difluorobenzylidene curcumin for treating bacterial infections0 aBioinspired hyaluronic acid based nanofibers immobilized with 3   cAUG  a1034800 v743 a<p>
	Curcumin (Cur) is a natural polyphenol with multifaceted pharmacological functions, exploited extensively for biomedical applications. Traditionally curcumin is being used as an antimicrobial agent. However, to improvise the pharmacological properties, it is being modified synthetically. One of such modified Cur is 3, 4- difluorobenzylidene curcumin (CDF) which is aimed for enhancing the anti-cancer properties. Though there are reports on the studies of anti-cancer properties involving CDF, the anti-bacterial property is yet to be demonstrated. Accordingly, in our studies, we prepared bioinspired hyaluronic acid blends immobilized with CDF and fabricated non-woven nanofiber mats. These nanofiber mats were characterized and demonstrated in vitro cell culture studies, which involved cell viability, hemolysis, anti-bacterial and cell scratch assay to understand their efficacy in treating bacteria. The molecular docking studies of CDF and Cur were performed on the dihydrofolate reductase (DHFR) enzyme receptor, which is an essential protein of S.auerus (Staphylococcus aureus). The results of MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) assay, and hemolysis of the respective nanofiber mats with Cur and CDF showed non-toxicity and were compatible with blood cells. Further, the cell proliferation and adherence recorded &gt;60% fibroblast cells for the nanofiber mats. The anti-bacterial property of Cur and CDF was similar. The in vitro release studies for the respective Cur and CDF loaded nanofiber mats recorded a release of 25 and 37%, respectively. From these studies, we concluded that the CDF sustained its antibacterial property in addition to the improved anti-cancer property; hence CDF being synergetic, it will have a better scope in cancer therapy.</p>
10aanti-bacterial10acurcumin10ananofibers10atissue engineering10awound Healing1 aPatel, Pratikshkumar, R.1 aSingam, Amarnath1 aIyer, Arun, K.1 aGundloori, Rathna, Venkata Na  uhttps://library.ncl.res.in/content/bioinspired-hyaluronic-acid-based-nanofibers-immobilized-3-4-difluorobenzylidene-curcumin01905nas a2200265   4500008004100000022001400041245014800055210006900203260000800272300001400280490000700294520096200301653002801263653001301291653001701304653001701321653002901338100003001367700002401397700002401421700001901445700002301464700002601487856012601513       2022                        eng d  a1040-663800a[DBUH][OAc]-catalyzed domino synthesis of novel benzimidazole incorporated 3,5-Bis (Arylidene)-4-piperidones as potential antitubercular agents0 aDBUHOAccatalyzed domino synthesis of novel benzimidazole incorpo  cNOV  a7010-70240 v423 a<p>
	A series of new benzimidazole incorporated 3,5-bis (arylidene)-4-piperidones were synthesized by using aryl aldehydes, piperidinone, 2-(chloromethyl)-benzimidazole and DBU acetate [DBUH][OAc] act as a catalyst under solvent free condition in excellent yields. The synthesized compounds were screened for their in vitro antimycobacterial activity against M. tuberculosis H37Ra (MTB) and M. bovis BCG strains. The compounds 4a, 4b, 4e, 4i, 4k and 4l are highly potent against both the strains. Most of the active compounds are non-cytotoxic against MCF-7, A549, HCT 116 and THP-1 cell lines. Furthermore, a molecular docking study of these compounds was carried out to investigate their binding pattern with the target, active site of mycobacterial enoyl-acyl carrier protein reductase (Inh A). Therefore, these compounds can be subjected for further optimization and drug development which could give promising chemical leads for treatment of TB.</p>
10aAntitubercular activity10acurcumin10aCytotoxicity10aIonic liquid10amulticomponent reactions1 aSubhedar, Dnyaneshwar, D.1 aShaikh, Mubarak, H.1 aNagargoje, Amol, A.1 aSarkar, Dhiman1 aKhedkar, Vijay, M.1 aShingate, Bapurao, B.  uhttps://library.ncl.res.in/content/dbuhoac-catalyzed-domino-synthesis-novel-benzimidazole-incorporated-35-bis-arylidene-402225nas a2200241   4500008004100000022001400041245010200055210006900157260000800226490000800234520137900242653001601621653001301637653002001650653002001670100001801690700002901708700002801737700002401765700002701789700003601816856013101852       2023                        eng d  a0927-776500aInhibitory effect of curcumin-artemisinin co-amorphous on Tau aggregation and Tau phosphorylation0 aInhibitory effect of curcuminartemisinin coamorphous on Tau aggr  cJAN0 v2213 a<p>
	Tau is a natively unfolded microtubule-associated protein. Tau neurofibrillary tangles are one of the hallmarks of Alzheimer's disease. The post-translational modifications of Tau lead to its pathological state. Phosphorylation is the key post-translational modification associated with Tauopathy. Curcumin is a polyphenolic compound pre-sent in the rhizomes of Curcuma longa. Curcumin has been reported to have remarkable medicinal properties in several diseases, but its poor solubility limits its therapeutic potency. Artemisinin is a sesquiterpene lactone, which has been known sience ancient times for its applications as a treatment for various diseases such as malaria, cancer, autoimmune disease, etc. In the present study, the potency of crystalline curcumin, crystalline artemisinin, and Cur-Art co-amorphous dispersion were evaluated against Tau pathology. The in-vitro ThS/ANS fluorescence and electron microscopy results suggested that curcumin and Cur-Art efficiently inhibited Tau aggregation. Furthermore, exposure to curcumin and Cur-Art co-amorphous restored the impaired nuclear transport in formaldehyde-stressed cells. Curcumin was also found to modulate the phosphorylation of Tau, which indicated the neuroprotective potency. Thus, curcumin and Cur-Art co-amorphous exhibit therapeutic potential against Tau protein in Alzheimer's disease.</p>
10aartemisinin10acurcumin10aPhosphorylation10aTau Aggregation1 aDubey, Tushar1 aSonawane, Shweta, Kishor1 aMannava, M., K. Chaitan1 aNangia, Ashwini, K.1 aChandrashekar, Madhura1 aChinnathambi, Subashchandrabose  uhttps://library.ncl.res.in/content/inhibitory-effect-curcumin-artemisinin-co-amorphous-tau-aggregation-and-tau-phosphorylation