01681nas a2200265   4500008004100000022001400041245010000055210006900155260000800224300001400232490000600246520083600252653000601088653001901094653002201113653001801135653001901153653001301172100002001185700001601205700001801221700001801239700002701257856013101284       2018                        eng d  a2365-654900aOne pot synthesis and biological evaluation of some new pyridine-3,5-dicarbonitrile derivatives0 aOne pot synthesis and biological evaluation of some new pyridine  cMAR  a3374-33780 v33 a<p>We have developed eco-friendly route for the synthesis of title compounds by using simple compounds like aromatic aldehydes, malononitrile, 4-bromothiophenol and NaHCO3. In continuation to this, a series of pyridine-3,5-dicarbonitriles were synthesized with excellent yields and assessed for their invitro antitubercular and antimicrobial activity. The results of the antimicrobial study showed potent antimicrobial activity as compared to the standard drugs (Chloramphenicol and Griseofulvin). It was noticed that the presence of electron donating groups significantly increases the antibacterial activity of the newly synthesized compounds. The title compounds further evaluated for antitubercular activity and from the promising results, they were found to possess significant biological activity against M. tuberculosis.</p>10a310a4-Arylpyridine10a5-dicarbonitriles10aAntimicrobial10aAntitubercular10aCatalyst1 aJoshi, Hitendra1 aShah, Nirav1 aSakar, Dhiman1 aDesai, N., C.1 aJadeja, Krunalsinh, A.  uhttps://library.ncl.res.in/content/one-pot-synthesis-and-biological-evaluation-some-new-pyridine-35-dicarbonitrile-derivatives