02057nas a2200241   4500008004100000022001400041245009800055210006900153260007300222300001200295490000700307520118200314653001901496653001401515653002801529653002401557100002501581700001801606700001901624700001901643700002301662856013001685       2016                        eng d  a0141-813000aShape and size engineered cellulosic nanomaterials as broad spectrum anti-microbial compounds0 aShape and size engineered cellulosic nanomaterials as broad spec  aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcJUN  a460-4650 v873 a<p>Oxidized celluloses have been used for decades as antimicrobial wound gauzes and surgical cotton. We now report the successful synthesis of a next generation narrow size range (25-35 nm) spherical shaped nanoparticles of 2,3,6-tricarboxycellulose based on cellulose I structural features, for applications as new antimicrobial materials. This study adds to our previous study of 6-carboxycellulose. A wide range of bacteria such as Escherichia coli, Staphloccocus aureus, Bacillus subtilis and Mycobacterium tuberculosis (non-pathogenic as well as pathogenic strains) were affected by these polymers in in vitro studies. Activity against Mycobacteria were noted at high concentrations (MIC99 values 250-1000 mu g/ml, as compared to anti-TB drug Isoniazid 0.3 mu g/ml). However, the broad spectrum activity of oxidized celluloses and their nanoparticles against a wide range of bacteria, including Mycobacteria, show that these materials are promising new biocompatible and biodegradable drug delivery vehicles wherein they can play the dual role of being a drug encapsulant as well as a broad spectrum anti-microbial and anti-TB drug. (C) 2016 Published by Elsevier B.V.</p>10aAnti-microbial10acellulose10aSpherical nanoparticles10aTricarboxycellulose1 aSharma, Priyanka, R.1 aKamble, Sunil1 aSarkar, Dhiman1 aAnand, Amitesh1 aVarma, Anjanikumar  uhttps://library.ncl.res.in/content/shape-and-size-engineered-cellulosic-nanomaterials-broad-spectrum-anti-microbial-compounds03000nas a2200361   4500008004100000022001400041245016800055210006900223260000800292300001100300490000700311520180600318653001902124653001602143653001202159653001902171653002402190653003002214100002002244700002002264700002702284700001602311700002002327700002102347700001902368700001802387700002002405700002102425700001702446700002202463700002602485856012702511       2021                        eng d  a2210-803300aAntimicrobial and antioxidant potential of a standardized ayurvedic formulation explains its clinical efficacy as gargles in post-radiotherapy oral cancer patients0 aAntimicrobial and antioxidant potential of a standardized ayurve  cDEC  a1005100 v303 aIntroduction: Exploring the antioxidant and antimicrobial potential of a standardized proprietary poly-herbal powder and evaluating its clinical efficacy as an Ayurvedic gargle (Gandush) for reducing oral microbial load and side effects of radiotherapy in oral cavity cancer patients was the aim of this pilot study. Methods: Formulation (Gandush Churna) comprising Terminalia chebula Retz., Terminalia bellirica (Gaertn.) Roxb., Phyllanthus emblica L. and Curcuma longa L. and its decoction (Gandush Kwath) were standardized. In-vitro antioxidant potential and antimicrobial activity against selective bacterial and fungal strains were studied. Oral cavity cancer patients who had undergone radiotherapy were enrolled. The decoction was prepared by soaking Gandush Churna in water, boiling and reducing by 50 %; and was used for gargling, twice a day, for 7 days. Total microbial count and identification of microbiota in the oral cavity as well as symptoms graded as per Common Terminology Criteria for Adverse Events, were noted before and after the treatment. Change in microbial load and shift in symptom gradations were analyzed. Results: A monograph with physicochemical, chromatography, safety and stability parameters was developed. The decoction possessed good in-vitro antioxidant and antimicrobial activities. Gargling therapy significantly reduced bacterial load while mildly controlled the fungal infection in oral cavity cancer patients. It significantly reduced the severity of symptoms viz. stomatitis and local pain, with considerably decreased xerostomia and dysphagia. Conclusions: Intervention of gargle therapy using poly-herbal formulation may serve as an effective complementary treatment to improve oral hygiene and reduce side effects of radiotherapy in oral cancer patients.10aAnti-microbial10aAntioxidant10aGandush10aGargle therapy10aOral cavity cancers10aRadiotherapy side effects1 aChavan, Sandeep1 aBhuvad, Sushama1 aKumbhlakar, Bhagyashri1 aAuti, Jyoti1 aWalunj, Tanhaji1 aPathak, Shridevi1 aTanpure, Rahul1 aGujar, Shweta1 aShinde, Jagdish1 aKulkarni, Arvind1 aGupta, Vidya1 aDeshmukh, Vineeta1 aSardeshmukh, Sadanand  uhttps://library.ncl.res.in/content/antimicrobial-and-antioxidant-potential-standardized-ayurvedic-formulation-explains-its