02057nas a2200241   4500008004100000022001400041245009800055210006900153260007300222300001200295490000700307520118200314653001901496653001401515653002801529653002401557100002501581700001801606700001901624700001901643700002301662856013001685       2016                        eng d  a0141-813000aShape and size engineered cellulosic nanomaterials as broad spectrum anti-microbial compounds0 aShape and size engineered cellulosic nanomaterials as broad spec  aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcJUN  a460-4650 v873 a<p>Oxidized celluloses have been used for decades as antimicrobial wound gauzes and surgical cotton. We now report the successful synthesis of a next generation narrow size range (25-35 nm) spherical shaped nanoparticles of 2,3,6-tricarboxycellulose based on cellulose I structural features, for applications as new antimicrobial materials. This study adds to our previous study of 6-carboxycellulose. A wide range of bacteria such as Escherichia coli, Staphloccocus aureus, Bacillus subtilis and Mycobacterium tuberculosis (non-pathogenic as well as pathogenic strains) were affected by these polymers in in vitro studies. Activity against Mycobacteria were noted at high concentrations (MIC99 values 250-1000 mu g/ml, as compared to anti-TB drug Isoniazid 0.3 mu g/ml). However, the broad spectrum activity of oxidized celluloses and their nanoparticles against a wide range of bacteria, including Mycobacteria, show that these materials are promising new biocompatible and biodegradable drug delivery vehicles wherein they can play the dual role of being a drug encapsulant as well as a broad spectrum anti-microbial and anti-TB drug. (C) 2016 Published by Elsevier B.V.</p>10aAnti-microbial10acellulose10aSpherical nanoparticles10aTricarboxycellulose1 aSharma, Priyanka, R.1 aKamble, Sunil1 aSarkar, Dhiman1 aAnand, Amitesh1 aVarma, Anjanikumar  uhttps://library.ncl.res.in/content/shape-and-size-engineered-cellulosic-nanomaterials-broad-spectrum-anti-microbial-compounds