02327nas a2200253 4500008004100000022001400041245008200055210006900137260000900206300001200215490000700227520152500234653001801759653001901777653001701796653001501813653002101828653001801849100002201867700002201889700002201911700002701933856011301960 2015 eng d a0928-493100aBioactive thermoresponsive polyblend nanofiber formulations for wound healing0 aBioactive thermoresponsive polyblend nanofiber formulations for  cMAR  a126-1370 v483 a

The rationale of this work is to develop new bioactive thermoresponsive polyblend nanofiber formulations for wound healing (topical). Various polymer compositions of thermoresponsive, poly(N-isopropylacrylamide), egg albumen and poly(epsilon-caprolactone) blend solutions with and without a drug [gatifloxacin hydrochloride, Gati] were prepared. Non-woven nanofibers of various compositions were fabricated using an electrospinning technique. The morphology of the nanofibers was analyzed by an environmental scanning electron microscope. The morphology was influenced by the concentration of polymer, drug, and polymer blend composition. Fourier transform infrared spectroscopy analysis showed the shift in bands due to hydrogen ion interactions between polymers and drug. Thermogram of PNIPAM/PCL/EA with Gati recorded a shift in lower critical solution temperature (LCST) and glass transition temperature (T-g) of PNIPAM. Similarly T-g and melting temperature (T-m) of PCL were shifted. X-ray diffraction patterns recorded a decrease in the crystalline state of PCL nanofibers and transformed crystalline drug to an amorphous state. In vitro release study of nanofibers with Gati showed initial rapid release up to 10 h, followed by slow and controlled release for 696 h (29 days). Nanofiber mats with Gati exhibited antibacterial properties to Staphylococcus aureus, supported suitable controlled drug release with in vitro cell viability and in vivo wound healing. (C) 2014 Elsevier B.V. All rights reserved.

10aAntibacterial10aCell viability10adrug release10ananofibers10athermoresponsive10awound Healing1 aPawar, Mahesh, D.1 aRathna, G., V. N.1 aAgrawal, Shubhang1 aKuchekar, Bhanudas, S. uhttps://library.ncl.res.in/content/bioactive-thermoresponsive-polyblend-nanofiber-formulations-wound-healing02401nas a2200241 4500008004100000022001400041245006600055210006600121260008700187300001200274490000700286520154300293653003101836653001501867653001201882653002101894653002401915100002901939700003401968700003502002700002902037856009302066 2015 eng d a0883-911500aBlends of shellac as nanofiber formulations for wound healing0 aBlends of shellac as nanofiber formulations for wound healing a1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLANDbSAGE PUBLICATIONS LTDcSEP a472-4890 v303 a

Shellac is being used in food, pharmaceutical, and agricultural industries. It is seldom used for biomedical applications due to its poor mechanical property and instability. We designed thermoresponsive shellac-based bioactive nanofiber mats that mimic extracellular matrix to extend their utility in wound healing. Various blend compositions of shellac, gelatin, and poly(N-isopropylacrylamide) enriched with a bioactive agent, nadifloxacin, were prepared and nanofiber mats were fabricated. The morphology of the nanofiber formation was influenced by the concentration of polymer, drug, and polymer blend composition. Polymer-drug interactions and thermal and crystalline properties of nanofiber mats were analyzed. The shellac/gelatin/poly(N-isopropylacrylamide) blend of composition 3%/7%/3% (w/v) was chosen to evaluate in vitro drug release. Release studies recorded slow, constant, and sustained release for 140h. The release kinetics and mechanism confirmed zero-order release with resultant r(2) values greater than 0.99, and the Korsmeyer-Peppas release exponent (n) was slightly higher than 0.8, which indicated that drug diffusion was anomalous or non-Fickian type and drug release followed diffusion involving chain stretching. Indirect cytotoxicity studies recorded insignificant toxicity against normal human fibroblast cells. In vivo studies demonstrated that drug-loaded nanofiber mats were more suitable for faster tissue regeneration as compared to nanofiber mats without drug and commercial nadifloxacin cream.

10adrug release and mechanism10ananofibers10aShellac10athermoresponsive10atissue regeneration1 aVannuruswamy, Garikapati1 aRathna, Gundloori, Venkata Na1 aGadgil, Bhagyashri, Shashikant1 aGadad, Anand, Panchaksha uhttps://library.ncl.res.in/content/blends-shellac-nanofiber-formulations-wound-healing-001818nas a2200217 4500008004100000022001400041245007900055210006900134260000800203300001200211490000600223520109400229653002501323653002701348653002901375653001501404653002901419100001801448700002401466856011001490 2020 eng d a2194-428800aPorphyrin-based conducting polymer hydrogel for supercapacitor application0 aPorphyrinbased conducting polymer hydrogel for supercapacitor ap cJUN a20000610 v83 a

Herein, the electrochemical properties and energy storage capability of a flexible, all-solid-state supercapacitor based on the supramolecular assembly of polypyrrole (PPy) and the anion of 5,10,15,20-tetrakis(4-sulfonatophenyl)-21H,23H-porphine manganese(III) chloride (MnTSPP) are reported. The electrode material consists of a conductive polymer hydrogel formed through the gelation initiated by cross-linking of the dopant MnTSPP anion in the PPy chains. The morphology of the cross-linked polymer hydrogel is that of a particle-decorated nanofiber, which can perform as a flexible supercapacitor electrode material with a specific capacitance of 300 Fg(-1) and capacitance retention of 78% up to 10 000 cycles. The anion of MnTSPP plays a pivotal role in enhancing the charge storage capability by facilitating the electron transfer between the polymer interchains. In addition, the steric hindrance due to the large size of the dopant counter ions of MnTSPP reduces the counterion drain effect and structural pulverization of PPy, thereby improving the capacitive retention.

10aconductive hydrogels10aenergy storage devices10aFlexible Supercapacitors10ananofibers10aporphyrin-based polymers1 aDas, Debasree1 aKurungot, Sreekumar uhttps://library.ncl.res.in/content/porphyrin-based-conducting-polymer-hydrogel-supercapacitor-application02321nas a2200277 4500008004100000022001400041245012700055210006900182260000900251300001100260490000800271520138700279653001901666653002801685653003101713653002001744653002901764653001501793653001001808100002201818700001701840700001901857700001701876700001801893856013201911 2021 eng d a0925-838800aConstruction of IrO2@Mn3O4 core-shell heterostructured nanocomposites for high performance symmetric supercapacitor device0 aConstruction of IrO2Mn3O4 coreshell heterostructured nanocomposi cDEC  a1613280 v8873 aIn the present work, we have designed and synthesized nanocomposite of IrO2@Mn3O4 with two-step simple and scalable chemical routes. In this route, nanofibers of IrO2 were synthesized by a single nozzle electrospinning technique onto which Mn3O4 was overlaid by a simple SILAR route. The ratio of Mn3O4 and IrO2 was varied by varying the SILAR cycles onto electrospun IrO2 thin film as 20, 40, 60, and 80 cycles. The structural, morphological, and energy storage performance of IrO2@Mn3O4 composite elec-trodes were investigated. A 2 V kinetic potential with a rectangular-shaped cyclic voltammogram was observed for the IrO2@Mn3O4 electrodes. Moreover, the specific capacitance of 1027 F/g at 1 mA/cm(2) was observed for the optimized electrode which is superior as compared with other electrodes. The opti-mized electrode showed better current and voltage than the individual compounds which might be due to the synergic effect of IrO2 and Mn3O4. Finally, a PVA-LiClO4 gel electrolyte-based solid-state IrO2@ Mn3O4//IrO2@Mn3O4 symmetric device was fabricated. The symmetric device possessed an energy density of 81 Wh/kg with a power delivery of 714 W/kg which was capable to light up a green LED. Hence, the 2D transition metal oxides laminated on 1D metal oxides with high conductivity can be promising electrodes for future research. (C) 2021 Elsevier B.V. All rights reserved.10aAnd nanoflakes10aCharge storage kinetics10aElectrochemical properties10aelectrospinning10aIrO2@Mn3O4 nanocomposite10ananofibers10aSILAR1 aBeknalkar, S., A.1 aTeli, A., M.1 aHarale, N., S.1 aShin, J., C.1 aPatil, P., S. uhttps://library.ncl.res.in/content/construction-iro2mn3o4-core-shell-heterostructured-nanocomposites-high-performance-symmetric02207nas a2200265 4500008004100000022001400041245010600055210006900161260000800230300001400238490000700252520132300259653002101582653001701603653002601620653001601646653002001662653001501682653001501697100002901712700001801741700001801759700003401777856013001811 2021 eng d a0032-388800aManipulating hydrophobicity of polyester nanofiber mats with egg albumin to enhance cell interactions0 aManipulating hydrophobicity of polyester nanofiber mats with egg cOCT a2496-25100 v613 aA hybrid of poly-l-lactic acid (PLA) and poly-epsilon-caprolactone (PCL) system was designed using hydrophilic generally regarded as safe (GRAS) protein, egg albumin (EA), and fabricated as nanofiber mats (NM) to facilitate improved cell interactions and functionality. Our studies include, preparation and analysis of physicochemical properties of NM. Surface morphology of NM was smooth with the diameter ranging from 250 to 400 nm. The contact angle of NM decreased from 80 to 45 degrees with the increase in EA concentration. The rate and extent of swelling was increased 3-folds with the addition of EA. Release studies of NM showed maximum amount of MTz was released with the increase in MTz concentration (>85%). The MTz interaction with EA and structure stability of EA was confirmed from fluorescence and circular dichroism studies. NM showed increase in inhibition of bacterial growth of Staphylococcus aureus and Escherichia coli with the increase in MTz concentration. Cell viability of the NM was >80% and also, the cell proliferation increased as EA content increased. NM hemolytic activity was less than 5% suggesting compatibility. Hence, results concluded that EA had regulated hydrophobicity, promoted cell interactions, and proliferation and therefore, NM is considered safe for tissue regeneration.10aBiocompatibility10aBiomaterials10adrug delivery systems10aegg albumin10aelectrospinning10ananofibers10apolyesters1 aPatel, Pratikshkumar, R.1 aPandey, Komal1 aKilli, Naresh1 aGundloori, Rathna, Venkata Na uhttps://library.ncl.res.in/content/manipulating-hydrophobicity-polyester-nanofiber-mats-egg-albumin-enhance-cell-interactions02661nas a2200241 4500008004100000022001400041245013400055210006900189260000800258300001100266490000700277520181500284653001902099653001302118653001502131653002302146653001802169100002902187700002102216700001902237700003402256856012902290 2022 eng d a1773-224700aBioinspired hyaluronic acid based nanofibers immobilized with 3, 4-difluorobenzylidene curcumin for treating bacterial infections0 aBioinspired hyaluronic acid based nanofibers immobilized with 3  cAUG a1034800 v743 a

Curcumin (Cur) is a natural polyphenol with multifaceted pharmacological functions, exploited extensively for biomedical applications. Traditionally curcumin is being used as an antimicrobial agent. However, to improvise the pharmacological properties, it is being modified synthetically. One of such modified Cur is 3, 4- difluorobenzylidene curcumin (CDF) which is aimed for enhancing the anti-cancer properties. Though there are reports on the studies of anti-cancer properties involving CDF, the anti-bacterial property is yet to be demonstrated. Accordingly, in our studies, we prepared bioinspired hyaluronic acid blends immobilized with CDF and fabricated non-woven nanofiber mats. These nanofiber mats were characterized and demonstrated in vitro cell culture studies, which involved cell viability, hemolysis, anti-bacterial and cell scratch assay to understand their efficacy in treating bacteria. The molecular docking studies of CDF and Cur were performed on the dihydrofolate reductase (DHFR) enzyme receptor, which is an essential protein of S.auerus (Staphylococcus aureus). The results of MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) assay, and hemolysis of the respective nanofiber mats with Cur and CDF showed non-toxicity and were compatible with blood cells. Further, the cell proliferation and adherence recorded >60% fibroblast cells for the nanofiber mats. The anti-bacterial property of Cur and CDF was similar. The in vitro release studies for the respective Cur and CDF loaded nanofiber mats recorded a release of 25 and 37%, respectively. From these studies, we concluded that the CDF sustained its antibacterial property in addition to the improved anti-cancer property; hence CDF being synergetic, it will have a better scope in cancer therapy.

10aanti-bacterial10acurcumin10ananofibers10atissue engineering10awound Healing1 aPatel, Pratikshkumar, R.1 aSingam, Amarnath1 aIyer, Arun, K.1 aGundloori, Rathna, Venkata Na uhttps://library.ncl.res.in/content/bioinspired-hyaluronic-acid-based-nanofibers-immobilized-3-4-difluorobenzylidene-curcumin02461nas a2200253 4500008004100000022001400041245009800055210006900153260000800222300001100230490000700241520162000248653001901868653001701887653002001904653002701924653001501951653001701966100002901983700002102012700001702033700003402050856012302084 2022 eng d a1773-224700aBlend of neem oil based polyesteramide as magnetic nanofiber mat for efficient cancer therapy0 aBlend of neem oil based polyesteramide as magnetic nanofiber mat cSEP a1036290 v753 a

Stearic acid-coated magnetic nanoparticles (SMN) and FU (5-Fluorouracil) were immobilized in the blends of neem oil-based polyesteramide and fabricated as nanofiber mat (NM) for controlled release of FU under the influence of an external magnetic field for targeted drug delivery to treat cancer efficiently. Analyzed the surface morphology of the fibers using E-SEM, it was observed that the fibers were smooth with the diameter ranging from 250 to 450 nm. TEM studies showed the uniform distribution of SMN in the nanofibers. The physico-chemical properties of NM and raw materials were analyzed using FTIR, TGA, and XRD. The results suggested that the polymers were well blended. In-vitro FU release studies of the NMs recorded a significant difference in the cumulative percentage of FU release from SMN-NMs. The SMN-NMs released 95% of FU in 4 h, whereas, NMs released 83% of FU in 24 h. The cell viability assay for the NM was evaluated in the L929 mouse fibroblast cells, where >75% of cells were viable. The hemolysis assay for the developed SMN-NF showed <5% of hemolysis, which indicated the NMs were safe for application. The anti-cancer activity of FU loaded SMN-NF was analyzed in the MCF-7 cancer cell line, which recorded more than 50% cell death within 24 h. From SQUID analysis, we found that the 10% SMN were superparamagnetic in nature, the magnetization at 30 kOe was observed to be 4.3 emu/g. Based on the in vitro results, we concluded that the developed SMN-NMs are recommended for in vivo studies to understand their efficacy for the targeted drug delivery to treat cancer.

10a5-Fluorouracil10adrug release10aelectrospinning10aMagnetic nanoparticles10ananofibers10aStearic acid1 aPatel, Pratikshkumar, R.1 aSingam, Amarnath1 aDadwal, Arun1 aGundloori, Rathna, Venkata Na uhttps://library.ncl.res.in/content/blend-neem-oil-based-polyesteramide-magnetic-nanofiber-mat-efficient-cancer-therapy