02426nas a2200265   4500008004100000022001400041245013100055210006900186260005700255300001400312490000700326520142100333653001801754653004401772653003301816653001401849653003701863100001801900700002401918700002501942700002201967700001701989700002302006856013102029       2009                        eng d  a1530-993200aNovel/conceptual floating pulsatile system using high internal phase emulsion based porous material intended for chronotherapy0 aNovelconceptual floating pulsatile system using high internal ph  a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGERcDEC  a1368-13800 v103 a<p>The aim of the present study was to design a novel/conceptual delivery system using ibuprofen, anticipated for chronotherapy in arthritis with porous material to overcome the formulation limits (multiple steps, polymers, excipients) and to optimize drug loading for a desired release profile suitable for in vitro investigations. The objective of this delivery system lies in the availability of maximum drug amount for absorption in the wee hours as recommended. Drug loading using 3(2) factorial design on porous carrier, synthesized by high internal phase emulsion technique using styrene and divinylbenzene, was done via solvent evaporation using methanol and dichloromethane. The system was evaluated in vitro for drug loading, encapsulation efficiency, and surface characterization by scanning electron, atomic force microscopy, and customized drug release study. This study examined critical parameters such as solvent volume, drug amount, and solvent polarity on investigations related to drug adsorption and release mostly favoring low-polarity solvent dichloromethane. Overall release in all batches ranged 0.98-52% in acidic medium and 71-94% in basic medium. These results exhibit uniqueness in achieving the least drug release of 0.98%, an ideal one, without using any release modifiers, making it distinct from other approaches/technologies for time and controlled release and for chronotherapy.</p>10achronotherapy10afloating pulsatile drug delivery system10ahigh internal phase emulsion10aibuprofen10amultiparticulate porous carriers1 aSher, Praveen1 aIngavle, Ganesh, C.1 aPonrathnam, Surendra1 aBenson, James, R.1 aLi, Nai-Hong1 aPawar, Atmaram, P.  uhttps://library.ncl.res.in/content/novelconceptual-floating-pulsatile-system-using-high-internal-phase-emulsion-based-porous-001892nas a2200229   4500008004100000022001400041245013700055210006900192260009600261300001000357490000800367520100900375653001301384653002601397653001401423653002201437653001501459100001701474700001901491700002001510856013201530       2010                        eng d  a1022-136000aUltrasound-triggered release of ibuprofen from a chitosan-mesoporous silica composite - a novel approach for controlled drug release0 aUltrasoundtriggered release of ibuprofen from a chitosanmesoporo  aPO BOX 10 11 61, D-69451 WEINHEIM, GERMANYbInt Union Pure & Appl Chem; German Res FdncJAN  a80-880 v2873 a<p>In this work, an attempt was made to synthesize a novel Chitosan-Mesoporous silica (CS-MS) hybrid composite to design a drug delivery system based on ultrasound triggered stimuli-responsive smart release. The in-vitro drug release properties of both the Mesoporous Silica (MS) and Chitosan (CS) hybrids were investigated. Ibuprofen (Ibu) was used as a model drug. The results from powder X-Ray diffraction (XRD) patterns, and BET N(2) adsorption isotherms exhibited that MS can accommodate drug molecules into the lumen of the channels and pores. Drug release, stimulated by temperature and pH of the release media was also investigated. We studied the Ultrasound (US) triggered release of Ibu in a simulated body fluid (pH 7.4). The results exhibited that US can be used as a non-invasive technique for drug release from polymeric materials. The enhancing effect of ultrasound on drug release is due to the Cavitation effect, without causing any significant destruction on the polymer morphology.</p>10aChitosan10adrug delivery systems10aibuprofen10aMesoporous silica10aUltrasound1 aDepan, Dilip1 aSaikia, Lakshi1 aSingh, Raj, Pal  uhttps://library.ncl.res.in/content/ultrasound-triggered-release-ibuprofen-chitosan-mesoporous-silica-composite-novel-approach-002420nas a2200277   4500008004100000022001400041245008900055210006900144260007500213300001400288490000700302520146100309653001301770653001701783653001401800653001501814653002301829653002801852653002501880100002301905700002301928700002101951700002701972700002401999856011902023       2012                        eng d  a0724-874100aMicrostructural elucidation of self-emulsifying system: effect of chemical structure0 aMicrostructural elucidation of selfemulsifying system effect of   a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGER/PLENUM PUBLISHERScAUG  a2180-21880 v293 a<p>Self-emulsifying systems (SES) emulsify spontaneously to produce fine oil-in-water emulsion when introduced into aqueous phase. The self-emulsification process plays an important role during formation of emulsion. The objective of current work was to understand and explore the inner structuration of SES through controlled hydration and further to study the influence of additive on the same which ultimately governs performance of final formulation in terms of droplet size. Droplet size of final formulations containing structural analogues of ibuprofen was determined. Microstructural properties of intermediate hydrated regimes of SES were investigated using techniques such as small angle X-ray scattering, differential scanning calorimetry and rheology. The current work established inverse relationship between droplet size of the formulations containing structural analogues of ibuprofen and their Log P values. Microstructural analysis of intermediate hydrated regimes of the prepared samples showed formation of local lamellar structure. Structural analogues of ibuprofen significantly altered microstructure of lamellae which was well correlated with the droplet size of final formulations. In vitro drug release study showed increase in dissolution rate of lipophillic drugs when formulated as SES. The current work emphasizes the fact that tailor-made formulations can be prepared by controlling the properties of intermediate regimes.</p>10aemulsion10aflurbiprofen10aibuprofen10aketoprofen10alamellar structure10aself-emulsifying system10astructural analogues1 aPatil, Sharvil, S.1 aVenugopal, Edakkal1 aBhat, Suresh, K.1 aMahadik, Kakasaheb, R.1 aParadkar, Anant, R.  uhttps://library.ncl.res.in/content/microstructural-elucidation-self-emulsifying-system-effect-chemical-structure-002187nas a2200265   4500008004100000022001400041245015300055210006900208260005700277300001400334490000700348520121000355653001701565653002001582653001401602653001501616653001901631653002701650100002301677700002301700700002101723700002701744700002401771856012601795       2015                        eng d  a1530-993200aExploring microstructural changes in structural analogues of ibuprofen-hosted in situ gelling system and its influence on pharmaceutical performance0 aExploring microstructural changes in structural analogues of ibu  a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGERcOCT  a1153-11590 v163 a<p>The present work explores inner structuration of in situ gelling system consisting of glyceryl monooleate (GMO) and oleic acid (OA). The system under study involves investigation of microstructural changes which are believed to govern the pharmaceutical performance of final formulation. The changes which are often termed mesophasic transformation were analysed by small angle Xray scattering (SAXS), differential scanning calorimetry (DSC), rheology and plane polarised light (PPL) microscopy. The current work revealed transformation of blank system from W/O emulsion to reverse hexagonal structure upon addition of structural analogues of ibuprofen. Such transformations are believed to occur due to increased hydrophobic volume within system as probed by SAXS analysis. The findings of SAXS studies were well supported by DSC, rheology and PPL microscopy. The study established inverse relationship between log P value of structural analogues of ibuprofen and the degree of binding of water molecules to surfactant chains. Such relationship had pronounced effect on sol-gel transformation process. The prepared in situ gelling system showed sustained drug release which followed Higuchi model.</p>10aflurbiprofen10ahexagonal phase10aibuprofen10aketoprofen10aliquid crystal10asustained drug release1 aPatil, Sharvil, S.1 aVenugopal, Edakkal1 aBhat, Suresh, K.1 aMahadik, Kakasaheb, R.1 aParadkar, Anant, R.  uhttps://library.ncl.res.in/content/exploring-microstructural-changes-structural-analogues-ibuprofen-hosted-situ-gelling-0