01134nas a2200217 4500008004100000022001400041245010300055210006900158260007700227300001400304520031800318653001900636653001600655653001500671653001600686100002800702700002300730700002600753700002300779856011400802 2007 eng d a1434-193X00aShort and efficient synthetic strategy for the total syntheses of (S)-(+)- and (R)-(-)-Plakolide A0 aShort and efficient synthetic strategy for the total syntheses o aPO BOX 10 11 61, D-69451 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcOCT a5059-50633 a

Concise and efficient total syntheses of anticancer agents (S)(+)-Plakolide A and (R)-(-)-Plakolide A were accomplished in eight steps and an overall yield of 39 % starting from geraniol. The key steps in our strategy are Sharpless asymmetric epoxidation, double elimination, and Stille coupling reactions.

10aCross-coupling10aepoxidation10ainhibitors10aolefination1 aMohapatra, Debendra, K.1 aPramanik, Chintnoy1 aChorghade, Mukund, S.1 aGurjar, Mukund, K. uhttps://library.ncl.res.in/content/short-and-efficient-synthetic-strategy-total-syntheses-s-and-r-plakolide-001080nas a2200217 4500008004100000022001400041245005900055210005500114260011700169300001000286520031600296653002000612653002400632653001500656653001600671653001200687100003200699700002400731700002200755856008500777 2009 eng d a1424-637600aFormal synthesis of (-) anisomycin via organocatalysis0 aFormal synthesis of anisomycin via organocatalysis aC/O ALAN R KATRITZKY, UNIV FLORIDA, DEPT CHEMISTRY, PO BOX 117200, GAINESVILLE, FL 32611 USAbARKAT USA INCcJAN a88-943 a

An efficient formal synthesis of (-) anisomycin (1), a potent antibiotic agent, has been achieved in good yields and excellent diastereoselectivity. The key steps are proline-catalyzed sequential alpha-amination or alpha-aminoxylation of aldehyde 2 followed by tandem Horner-Wadsworth-Emmons olefination.

10aalpha-Amination10aalpha-aminoxylation10aanisomycin10aolefination10aProline1 aChouthaiwale, Pandurang, V.1 aKotkar, Shriram, P.1 aSudalai, Arumugam uhttps://library.ncl.res.in/content/formal-synthesis-anisomycin-organocatalysis-001153nas a2200217 4500008004100000022001400041245010400055210006900159260007500228300001400303490000700317520036300324653001800687653001000705653002100715653001600736653001500752100002300767700002200790856012300812 2016 eng d a0936-521400aConcise enantioselective synthesis of (+)-L-733,060 and (+)-T-2328 via sequential proline catalysis0 aConcise enantioselective synthesis of L733060 and T2328 via sequ aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcJUN a1339-13430 v273 a

A new, sequential proline-catalyzed approach to the synthesis of (+)-L-733,060 and (+)-T-2328 in high optical purity (93% ee) is described starting from phenyl N-Boc imine. The strategy involves proline-catalyzed Mannich reaction of an arylimine with acetaldehyde followed by -aminoxylation/Wittig olefination in a sequential fashion as the key steps.

10aAminoxylation10aimine10aMannich reaction10aolefination10asequential1 aLalwani, Komal, G.1 aSudalai, Arumugam uhttps://library.ncl.res.in/content/concise-enantioselective-synthesis-l-733060-and-t-2328-sequential-proline-catalysis01434nas a2200229 4500008004100000022001400041245011900055210006900174260000800243300001200251490000700263520064000270653002000910653001100930653002300941653001600964653001400980100002700994700002201021700002601043856013501069 2025 eng d a0936-521400aHypervalent-iodine-mediated base-free oxidative olefination of benzylic amines to access α,β-unsaturated ketones0 aHypervalentiodinemediated basefree oxidative olefination of benz cAUG a556-5600 v363 a

We report a one-pot base-free protocol for the oxidative olefination of benzylic amines promoted by a hypervalent iodine reagent for the synthesis of alpha,beta-unsaturated ketones. Mechanistically, (diacetoxyiodo)benzene oxidizes the benzylic amine to the corresponding imine, which, on reaction with a phenacyl(triphenyl)phosphonium bromide salt and an in situ generated acetoxy anion leads to an alpha,beta-unsaturated ketone. A wide range of alpha,beta-unsaturated ketones were easily accessed through direct oxidative olefination of substituted benzylic amines in good to excellent yields and with high E -selectivity.

10abenzylic amines10aenones10ahypervalent iodine10aolefination10aOxidation1 aRupanawar, Bapurao, D.1 aBansode, Ajay, H.1 aSuryavanshi, Gurunath uhttps://library.ncl.res.in/content/hypervalent-iodine-mediated-base-free-oxidative-olefination-benzylic-amines-access-%CE%B1%CE%B2