02379nas a2200385   4500008004100000022001400041245010600055210006900161260010600230300001400336490000700350520105700357653000601414653000601420653002801426653001501454653002201469653002101491653002501512653002901537653001901566653002401585100002601609700002401635700001901659700002201678700001901700700002701719700002401746700002401770700002101794700002601815700002601841856012601867       2009                        eng d  a0968-089600aExploration of click reaction for the synthesis of modified nucleosides as chitin synthase inhibitors0 aExploration of click reaction for the synthesis of modified nucl  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAR  a2433-24400 v173 a<p>Click reaction approach toward the synthesis of two sets of novel 1,2,3-triazolyl linked uridine derivatives 19a-19g and 21a-21g was achieved by Cu(I)-catalyzed 1,3-dipolar cycloaddition of 5'-azido-5'-deoxy-2',3'-O-(1-methylethylidene) uridine (17) with propargylated ether of phenols 18a-18g and propargylated esters 20a-20g. Structure of one of the representative compound 19d was unambiguously confirmed by X-ray crystallography. Chitin synthase inhibition study of all these compounds 19a-19g and 21a-21g was carried out to develop antifungal strategy. Compounds 19d, 19e, 19f, and 21f were identified as potent chitin synthase inhibitors by comparing with nikkomycin. Compounds 19a, 19b, 19c, 19d, 21a, and 21b showed good antifungal activity against human and plant pathogens. Compounds 19a, 19b, 19f, 21c, 21f, and 21g were identified as lead chitin synthase inhibitors for further modi. cations by comparing results of inhibition of growth, % germ tube formation and chitin synthase activity. (C) 2009 Elsevier Ltd. All rights reserved.</p>10a110a210a3-dipolar cycloaddition10a3-Triazole10a4-Disubstituted-110a5 `-Azidouridine10aAntifungal compounds10aChitin synthase activity10aClick reaction10aUridine nucleosides1 aChaudhary, Preeti, M.1 aChavan, Sayalee, R.1 aShirazi, Fazal1 aRazdan, Meenakshi1 aNimkar, Prachi1 aMaybhate, Shailaja, P.1 aLikhite, Anjali, P.1 aGonnade, Rajesh, G.1 aHazra, Braja, G.1 aDeshpande, Mukund, V.1 aDeshpande, Sunita, R.  uhttps://library.ncl.res.in/content/exploration-click-reaction-synthesis-modified-nucleosides-chitin-synthase-inhibitors-001969nas a2200217   4500008004100000022001400041245014500055210006900200260000800269300001200277490000700289520120000296653001901496653001801515653002501533653001101558653002001569100001801589700001801607856012601625       2017                        eng d  a1380-222400aSynthesis and characterization of D-2PA-Pd(II)@SBA-15 catalyst via ``click chemistry'': highly active catalyst for Suzuki coupling reactions0 aSynthesis and characterization of D2PAPdIISBA15 catalyst via cli  cAPR  a327-3400 v243 a<p>Copper catalysed cycloaddition reaction between azide and terminal alkyne, called as ``click reaction'', was found to be modular approach for the synthesis of facile, highly efficient and recoverable D-2PA-Pd(II)@SBA-15 catalyst. In efforts to synthesize the catalyst, the cycloaddition reaction between azido-functionalized mesoporous SBA-15 and N,N-dimethyl-2-propynylamine (D-2PA) has been carried out, followed by the complexation with PdCl2. To analyze physiochemical properties of synthesized materials, various characterization techniques such as CHN elemental analysis, X-ray diffraction, solid state C-13 and Si-29 NMR spectra, FT-IR, XPS, SEM, TEM and N-2 sorption analysis, TGA and DTA, UV-Vis spectroscopy have been carried out. The synthesized catalyst, D-2PA-Pd(II)@SBA-15, exhibited excellent catalytic activities with good product yield and high TON towards Suzuki coupling reaction of various aryl halides with phenylboronic acid. The effect of solvent, base and temperature on coupling reactions has also been described. The developed protocol offers recyclability of catalyst for multiple (four) times without any appreciable loss in stability and catalytic reactivity.</p>10aClick reaction10aCycloaddition10amesoporous materials10aSBA-1510aSuzuki coupling1 aPathak, Aruna1 aSingh, A., P.  uhttps://library.ncl.res.in/content/synthesis-and-characterization-d-2pa-pdiisba-15-catalyst-click-chemistry-highly-active01646nas a2200229   4500008004100000022001400041245010700055210006900162260000800231300001400239490000700253520085700260653001901117653002101136653001901157653002701176653001401203100002201217700002401239700002301263856013001286       2020                        eng d  a1433-785100aCrystal-to-crystal synthesis of helically ordered polymers of trehalose by topochemical polymerization0 aCrystaltocrystal synthesis of helically ordered polymers of treh  cFEB  a2897-29030 v593 a<p>The synthesis of crystalline helical polymers of trehalose via topochemical azide-alkyne cycloaddition (TAAC) of a trehalose-based monomer is presented. An unsymmetrical trehalose derivative having azide and alkyne crystallizes in two different forms having almost similar packing. Upon heating, both the crystals undergo TAAC reaction to form crystalline polymers. Powder X-ray diffraction (PXRD) studies revealed that the monomers in both the crystals polymerize in a crystal-to-crystal fashion; circular dichroism (CD) studies of the product crystals revealed that the formed polymer is helically ordered. This solvent-free, catalyst-free polymerization method that eliminates the tedious purification of the polymeric product exemplifies the advantage of topochemical polymerization reaction over traditional solution-phase polymerization.</p>
10aClick reaction10ahelical polymers10apolysaccharide10atopochemical reactions10atrehalose1 aHema, Kuntrapakam1 aGonnade, Rajesh, G.1 aSureshan, Kana, M.  uhttps://library.ncl.res.in/content/crystal-crystal-synthesis-helically-ordered-polymers-trehalose-topochemical-polymerization02265nas a2200253   4500008004100000022001400041245009000055210007000145260000900215300000700224490000800231520140700239653001601646653001901662653003001681653003601711653002001747100002601767700002001793700003001813700002201843700002001865856012601885       2025                        eng d  a0974-362600aDesign and synthesis of C-α-D-mannopyranoside linked mesoporous silica nanoparticles0 aDesign and synthesis of CαDmannopyranoside linked mesoporous sil  cMAR   a210 v1373 a<p>
	Mannose functionalized mesoporous silica nanoparticles (MSNs) offer a promising approach for developing more targeted, effective, and safer cancer therapies. For many of the applications, immobilization of carbohydrates like mannose onto MSNs is a crucial aspect, and in most cases, mannose moieties are connected through O-glycosidic linkages that are susceptible to acidic/enzymatic hydrolysis. To generate a stable mannose-functionalized MSN, we designed a novel C(14)-alpha-mannosylated tetradeca-1-yne. The key steps involved in the synthesis of C-mannosylated alkyne are C1-alkynylation of tri-O-acetyl-D-glucal with 1-trimethylsilyl-tetradec-1-yne, followed by stereoselective dihydroxylation and the isomerization of the internal triple bond to a terminal position. This mannose ligand was then immobilized onto azidopropyl-functionalized SBA-15 through the Cu(I)-catalyzed azide-alkyne click (CuAAC) reaction. Various physical techniques such as low-angle powder XRD, N-2 adsorption isotherms (BET), Fourier transform infrared (FTIR), high-resolution transmission electron microscopy (HRTEM), field emission scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA) have been employed to characterize this C-mannosyl SBA-15 silica matrix. We evaluated the binding ability of C-mannosyl SBA-15 nanoparticles by using fluorescein-labelled Con-A as a target protein.</p>
10aC-mannoside10aClick reaction10amannose specific proteins10aMesoporous silica nanoparticles10aZipper reaction1 aNechooli, Hemanth, K.1 aRamtenki, Vilas1 aKumar, Chepuri, V. Suneel1 aPrasad, V., B. L.1 aRamana, Chepuri  uhttps://library.ncl.res.in/content/design-and-synthesis-c-%CE%B1-d-mannopyranoside-linked-mesoporous-silica-nanoparticles