02188nas a2200217 4500008004100000022001400041245016700055210006900222260006800291300001400359490000800373520133400381653001301715653002101728653002601749653002301775653001401798100001401812700001701826856012701843 2008 eng d a0021-899500aSynthesis and FTIR spectroscopic investigation of the UV curing kinetics of telechelic urethane methacrylate crosslinkers based on the renewable resource-cardanol0 aSynthesis and FTIR spectroscopic investigation of the UV curing  a111 RIVER ST, HOBOKEN, NJ 07030 USAbJOHN WILEY & SONS INCcSEP a2781-27900 v1093 a

UV curable telechelic urethane-methacrylate crosslinkers based on the natural resource-cardanol was synthesized in a one pot synthetic step involving end capping of isophorone diisocyanate with one equivalent of hydroxyethyl methacrylate followed by condensation with cardanol. The structures of the resins were characterized by H-1 and C-13 NMR, fourier transform infrared (FTIR) and Matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) spectroscopies and size exclusion chromatography (SEC). The curing process and double bond conversion in presence of 2,2-diethoxy acetophenone as photo-initiator upon UV irradiation was followed by Fourier transform infrared spectroscopy. These hydrogen bonded crosslinkers based on cardanol and its derivatives had higher double bond conversion when compared to a nonhydrogen bonding standard such as hexanediol diacrylate (HDDA) under identical conditions. The temperature effects on the hydrogen bonding were investigated, and a decrease in the extent of double bond conversion with increase in temperature was observed for the telechelic urethane-methacrylate crosslinkers whereas a steady increase in the curing rate was observed for HDDA. This gives direct indication of the influence of hydrogen bonding on the curing process. (C) 2008 Wiley Periodicals, Inc.

10aCardanol10ahydrogen bonding10ainfrared spectroscopy10arenewable resource10aUV curing1 aRekha, N.1 aAsha, S., K. uhttps://library.ncl.res.in/content/synthesis-and-ftir-spectroscopic-investigation-uv-curing-kinetics-telechelic-urethane-002992nas a2200241 4500008004100000022001400041245009100055210006900146260009900215300001200314490000700326520209300333653001302426653002802439653002202467653001902489653002202508653002202530100002102552700002402573700002802597856012502625 2010 eng d a0141-391000aPoly(amideimide)s containing pendant pentadecyl chains: synthesis and characterization0 aPolyamideimides containing pendant pentadecyl chains synthesis a aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLANDbELSEVIER SCI LTDcMAY a837-8440 v953 a

A new aromatic diacylhydrazide monomer viz., 4-[4'-(hydrazinocarbonyl)phenoxy]-2- pentadecylbenzo-hydrazide was synthesized starting from cardanol, which in turn is obtainable from cashew nut shell liquid a renewable resource material. A series of new poly(amideimide)s containing flexibilizing ether linkages and pendant pentadecyl chains was synthesized from 4-[4'-(hydrazinocarbonyl)phenoxy]-2-pentade-cylbenzohydrazide and commercially available aromatic dianhydrides, viz., benzene-1,2,4,5-tetracarboxylic dianhydride, 3,3',4,4'-biphenyltetracarboxylic dianhydride, benzophenone-3,3',4,4'-tetracarboxylic dianhydride, 4,4'-oxydiphthalic anhydride and 4,4'-(hexafluoro isopropylidene)diphthalic anhydride by a two-step solution polycondensation in N,N-dimethylacetamide via the poly(hydrazide acid) intermediate. Inherent viscosities of poly(amideimide)s were in the range 0.60-0.64 dL/g in N,N-dimethylacetamide at 30 +/- 0.1 degrees C. Poly(amideimide)s could be solution cast into tough, transparent and flexible films from their N,N-dimethylacetamide solutions. The solubility of poly(amideimide)s was significantly improved by incorporation of pendant pentadecyl chains and were found to be soluble in N,N-dimethylacetamide, 1-methyl-2-pyrrolidinone, pyridine and m-cresol at room temperature or upon heating. Wide angle X-ray diffraction patterns of poly(amideimide)s revealed a broad halo at around 2 theta = similar to 19 degrees suggesting that polymers were amorphous in nature. In the small-angle region, diffuse to sharp reflections of a typically layered structure resulting from the packing of pentadecyl side chains were observed. The temperature at 10% weight loss (T(10)), determined by TGA in nitrogen atmosphere, of poly(amideimide)s was in the range of 388-410 degrees C indicating their good thermal stability. Glass transition temperatures of poly(amideimide)s were in the range 162-198 degrees C. It was observed that the plasticization effect of attached pentadecyl side chains induced the depression of T(g). (C) 2010 Elsevier Ltd. All rights reserved.

10aCardanol10aCashew nut shell liquid10aPentadecyl chains10aPlasticization10aPoly(amideimide)s10athermal stability1 aMore, Arvind, S.1 aPatil, Anandrao, S.1 aWadgaonkar, Prakash, P. uhttps://library.ncl.res.in/content/polyamideimides-containing-pendant-pentadecyl-chains-synthesis-and-characterization-002596nas a2200229 4500008004100000022001400041245008600055210006900141260010600210300001200316490000700328520174000335653002102075653001302096653002802109653002202137653001502159100002102174700002302195700002802218856012002246 2010 eng d a0014-305700aSynthesis and characterization of polyamides containing pendant pentadecyl chains0 aSynthesis and characterization of polyamides containing pendant  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAR a557-5670 v463 a

A new aromatic diacid monomer viz., 4-(4'-carboxyphenoxy)-2-pentadecylbenzoic acid was synthesized starting from cardanol and was characterized by FTIR, (1)H- and (13)C NMR spectroscopy. A series of new aromatic polyamides containing ether linkages and pendant pentadecyl chains was prepared by phosphorylation polycondensation of 4-(4'-carboxyphenoxy)-2-pentadecylbenzoic acid with five commercially available aromatic diamines viz., 1,4-phenylenediamine, 4,4'-oxydianiline, 4,4'-methylenedianiline, 1,3-phenylenediamine, and 4,4'-(hexafluoroisopropylidene)dianiline. Inherent viscosities of the polyamides were in the range 0.45-0.66 dL/g in N,N-dimethylacetamide at 30 +/- 0.1 degrees C. The introduction of ether linkages and pendant pentadecyl chains into polyamides led to an enhanced solubility in N,N-dimethylacetamide and 1-methyl-2-pyrrolidinone at room temperature or upon heating. The polyamides could be solution-cast into tough, flexible and transparent films from their N,N-dimethylacetamide solution. Wide angle X-ray diffraction patterns exhibited broad halo indicating that the polymers were essentially amorphous in nature. X-Ray diffractograms also displayed a diffuse to sharp reflection in the small-angle region (20 = similar to 2-5 degrees) for the polyamides characteristics of formation of loosely to well-developed layered structure arising from packing of flexible pentadecyl chains. The glass transition temperature observed for the polyamides was in range 139-189 degrees C. The temperature at 10% weight loss (T(10)), determined by TGA in nitrogen atmosphere, of the polyamides was in the range 425-453 degrees C indicating their good thermal stability. (C) 2009 Elsevier Ltd. All rights reserved.

10aalkyl side-chain10aCardanol10aCashew nut shell liquid10aPentadecyl chains10apolyamides1 aMore, Arvind, S.1 aPasale, Sharad, K.1 aWadgaonkar, Prakash, P. uhttps://library.ncl.res.in/content/synthesis-and-characterization-polyamides-containing-pendant-pentadecyl-chains-001634nas a2200217 4500008004100000022001400041245011900055210006900174260000800243300001200251490000600263520088000269653001301149653002301162653002101185653001801206653001501224100002301239700002601262856012801288 2018 eng d a2365-654900aNovel pentadecyl phenol-tagged L-tryptophan molecules: synthesis, self- assembly and liquid crystalline properties0 aNovel pentadecyl phenoltagged Ltryptophan molecules synthesis se cJAN a108-1150 v33 a

The paper describes the self-assembly and liquid crystalline properties of pentadecylphenol tagged L-tryptophan molecules having ester and amide functionality. We have synthesized a series of molecules having mono and ditryptophan moieties attached to pentadecylphenol through amide or ester linkage. The fluorescence properties of the Boc-L-tryptophan-pentadecylphenol molecules were measured in methanol and found to aggregate beyond the critical aggregation concentration and self-assembled to give spherical structures. Upon deprotection of Boc group, the amine end group got involved in extended hydrogen bonding and fibril like structures were developed. These molecules also showed liquid crystalline behavior in hydrogen bonding solvents such as benzyl alcohol and showed needle like crystals in tert-butanol, as analyzed by polarized optical light microscopy.

10aCardanol10aliquid crystalline10apentadecylphenol10aSelf-assembly10aTryptophan1 aParappurath, Akhil1 aAbraham, Jancy, Nixon uhttps://library.ncl.res.in/content/novel-pentadecyl-phenol-tagged-l-tryptophan-molecules-synthesis-self-assembly-and-liquid02384nas a2200253 4500008004100000022001400041245011400055210006900169260000800238300001000246490000700256520154000263653002001803653002001823653001301843653001501856653001501871100002101886700002001907700003001927700002201957700002601979856012502005 2022 eng d a1075-261700aTryptophan-cardanol fluorescent nanoparticles inhibit alpha-synuclein aggregation and disrupt amyloid fibrils0 aTryptophancardanol fluorescent nanoparticles inhibit alphasynucl cAPR ae33740 v283 a

Protein misfolding and aggregation play a vital role in several human diseases such as Parkinson's, Alzheimer's, and prion diseases. The development of nanoparticles that modulate aggregation could be potential drug candidates for these neurodegenerative disorders. Parkinson's disease pathogenesis is closely associated with the accumulation of alpha-synuclein oligomers and fibrils in the substantia nigra of the brain. This report discusses the interactions of novel tryptophan-cardanol nanoparticles with alpha-synuclein protein monomers and fibrils. These nanoparticles could effectively disrupt alpha-synuclein fibrils and inhibit fibril formation at low concentrations such as 5 mu M. The tryptophan-cardanol nanoparticles inhibit fibril formation from unstructured protein resulting in spherical nanostructures. These nanoparticles could also disassemble amyloid fibrils; the complete disappearance of fibrils was evident after 48 h of incubation with tryptophan-cardanol. The transmission electron microscopy (TEM) micrographs after the incubation did not show any remnants of the peptide aggregates or oligomers. The thioflavin T fluorescence after the disassembly was diminished compared with that of fibrils also supports the inhibitory effect of the nanoparticles. Also, these nanoparticles did not reduce the viability of the SH-SY5Y cells. These findings suggest that the tryptophan-cardanol nanoparticles showed sufficiently high inhibitory activity and may have therapeutic potential for synucleinopathies.

10aalpha-synuclein10aamyloid fibrils10aCardanol10ainhibitors10aTryptophan1 aSunny, Lisni, P.1 aSrikanth, Priya1 aSunitha, Anju, Kunhiraman1 aTembulkar, Niyoti1 aAbraham, Jancy, Nixon uhttps://library.ncl.res.in/content/tryptophan-cardanol-fluorescent-nanoparticles-inhibit-alpha-synuclein-aggregation-and02050nas a2200217 4500008004100000022001400041245008700055210006900142260000800211300001200219490000700231520134100238653002701579653001301606653002001619653001701639653001501656100002601671700002301697856011201720 2024 eng d a2062-249X00aContinuous flow ozonolysis of cardanol for greener synthesis of bio-based monomers0 aContinuous flow ozonolysis of cardanol for greener synthesis of  cJUN a417-4260 v143 a

Synthesis of bio-based monomers via continuous flow ozonolysis of cardanol using a simple tubular reactor is demonstrated. The direct ozonolysis of cardanol produces unique monomer 8-(3-hydroxyphenyl) octanal (HPOA) and heptanal along with several other oxidation products. Maximum 47% yield of HPOA with 54.3% conversion of cardanol was obtained at 0 degrees C in 9 s. The complete conversion of cardanol was obtained at the ozone to cardanol molar flow ratios greater than 2 at all temperatures varied in the range of -10 degrees C to 20 degrees C. Owing to large gas-liquid ratios, the mass transfer limitation for transfer of ozone from gas to liquid was negligible; however, the extent of axial dispersion in the liquid phase was significant at lower liquid flow rates. The non-ideal behavior was incorporated in the axial dispersion model to predict the conversion of cardanol. Examination of kinetic rates by both ideal plug-flow model and plug-flow with axial dispersion model revealed that the reaction is fast and is least influenced by the axial-dispersion in the reactor at prevailing operating conditions. The findings of the current study show that continuous flow technique enables a simple and safer synthesis of high-value bio-based monomers via ozonolysis of cardanol compared to traditional batch methods.

10aAxial-dispersion model10aCardanol10acontinuous flow10aHelical coil10aOzonolysis1 aKulkarni, Sphurti, P.1 aKulkarni, Amol, A. uhttps://library.ncl.res.in/content/continuous-flow-ozonolysis-cardanol-greener-synthesis-bio-based-monomers