00989nas a2200217   4500008004100000022001400041245004700055210004700102260010600149300001400255490000700269520028000276653001300556653001500569653001700584653002000601100002400621700002200645700002300667856008100690       2007                        eng d  a0040-403900aPractical formal synthesis of camptothecin0 aPractical formal synthesis of camptothecin  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcSEP  a6561-65630 v483 a<p>The synthesis of the DE ring of camptothecin using simple and inexpensive starting materials, employing an addition elimination reaction and selective esterification of an aliphatic carboxylic acid as key steps is described. (C) 2007 Elsevier Ltd. All rights reserved.</p>10aalkaloid10aAnticancer10acamptothecin10aNatural product1 aChavan, Subhash, P.1 aPathak, Ashok, B.1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/practical-formal-synthesis-camptothecin-000996nas a2200241   4500008004100000022001400041245005900055210005900114260008600173300001400259490000700273520021100280653001300491653002100504653002000525653000800545653002000553100002400573700002200597700002600619700002300645856008600668       2007                        eng d  a0039-791100aTotal synthesis of pulchellalactam via an RCM strategy0 aTotal synthesis of pulchellalactam via an RCM strategy  a325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USAbTAYLOR & FRANCIS INCcMAY  a1503-15100 v373 a<p>Total synthesis of (Z) pulchellalactam, a CD protein tyrosine phosphatase inhibitor, from commercially available methallyl chloride employing ring-closure metathesis (RCM) as a key step is described.</p>10aalkaloid10aNatural products10apulchellalactam10aRCM10aTotal synthesis1 aChavan, Subhash, P.1 aPathak, Ashok, B.1 aDhawane, Abasaheb, N.1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/total-synthesis-pulchellalactam-rcm-strategy-000956nas a2200217   4500008004100000022001400041245008100055210006800136260007500204300001400279520018400293653001300477653001400490653002500504653002200529653001600551653002000567100002600587700001900613856010600632       2010                        eng d  a0039-788100aConcise synthesis of (2S,3S,4S)-2-(Hydroxymethyl)pyrrolidine-3,4-diol (LAB1)0 aConcise synthesis of 2S3S4S2Hydroxymethylpyrrolidine34diol LAB1  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcSEP  a3063-30663 a<p>The synthesis of (2S,3S,4S)-2-(hydroxymethyl)pyrrolidine-3,4-diol (LAB1) from Garner's aldehyde is described using the Sharpless asymmetric dihydroxylation as the key step.</p>10aalkaloid10aazasugars10adiastereoselectivity10aGarner's aldehyde10apyrrolidine10aWittig reaction1 aUpadhyay, Puspesh, K.1 aKumar, Pradeep  uhttps://library.ncl.res.in/content/concise-synthesis-2s3s4s-2-hydroxymethylpyrrolidine-34-diol-lab1-002694nas a2200229   4500008004100000245008200041210006900123260000800192300000900200490000700209520197100216653001302187653002402200653001902224653001202243653001102255653001702266100002102283700002902304700002002333856011102353       2021                        eng d00aDiversity in chemical structures and biological properties of plant alkaloids0 aDiversity in chemical structures and biological properties of pl  cJUN  a33740 v263 aPhytochemicals belonging to the group of alkaloids are signature specialized metabolites endowed with countless biological activities. Plants are armored with these naturally produced nitrogenous compounds to combat numerous challenging environmental stress conditions. Traditional and modern healthcare systems have harnessed the potential of these organic compounds for the treatment of many ailments. Various chemical entities (functional groups) attached to the central moiety are responsible for their diverse range of biological properties. The development of the characterization of these plant metabolites and the enzymes involved in their biosynthesis is of an utmost priority to deliver enhanced advantages in terms of biological properties and productivity. Further, the incorporation of whole/partial metabolic pathways in the heterologous system and/or the overexpression of biosynthetic steps in homologous systems have both become alternative and lucrative methods over chemical synthesis in recent times. Moreover, in-depth research on alkaloid biosynthetic pathways has revealed numerous chemical modifications that occur during alkaloidal conversions. These chemical reactions involve glycosylation, acylation, reduction, oxidation, and methylation steps, and they are usually responsible for conferring the biological activities possessed by alkaloids. In this review, we aim to discuss the alkaloidal group of plant specialized metabolites and their brief classification covering major categories. We also emphasize the diversity in the basic structures of plant alkaloids arising through enzymatically catalyzed structural modifications in certain plant species, as well as their emerging diverse biological activities. The role of alkaloids in plant defense and their mechanisms of action are also briefly discussed. Moreover, the commercial utilization of plant alkaloids in the marketplace displaying various applications has been enumerated.10aalkaloid10aBiological activity10aclassification10adefense10aEnzyme10amodification1 aBhambhani, Sweta1 aKondhare, Kirtikumar, R.1 aGiri, Ashok, P.  uhttps://library.ncl.res.in/content/diversity-chemical-structures-and-biological-properties-plant-alkaloids