02190nas a2200277 4500008004100000022001400041245009100055210006900146260009200215300001200307490000600319520125600325653001601581653001801597653001201615653001301627653001701640100001801657700001801675700001901693700002401712700001801736700002001754700001801774856012001792 2011 eng d a1936-661200aControlling stoichiometry in low temperature synthesis of La0.7Sr0.3MnO3 nanoparticles0 aControlling stoichiometry in low temperature synthesis of La07Sr a26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USAbAMER SCIENTIFIC PUBLISHERScFEB a424-4300 v43 a

Nanoparticles of complex oxides (<20 nm) are desirable for several applications in view of the diverse range of physical properties of such oxides. However the simultaneous presence of multiple cation precursors makes the corresponding chemical synthesis non-trivial with possible intermediate evolution of secondary phases. Such phases could react at high temperatures to form the desired stoichiometry, but this process is diffusion limited and can lead to larger particles. In this work we examine the role of three different reaction and growth controlling additives, namely dextran, citric acid and hexamine, on the synthesis of the well known colossal magneto-resistive (CMR) manganite La0.7Sr0.3MnO3. We demonstrate that phase evolutions differ significantly in the three cases, and the physical properties of the products also differ dramatically. Only dextran is shown to yield the desired phase with faceted nanoparticles at as low a temperature as 600 degrees C. A high saturation moment of similar to 47 emu/gm is realized at 10 K with a good square hysteresis loop. In 650 degrees C annealed sample, room temperature magnetization of similar to 15 emu/gm was obtained, which brings the nanoparticles in the applicability domain.

10aCitric acid10aComplex Oxide10aDextran10aHexamine10ahydrothermal1 aAzarifar, Ali1 aYadav, P., A.1 aChawla, A., K.1 aJog, Jyoti, Prakash1 aPatil, S., I.1 aChandra, Ramesh1 aOgale, S., B. uhttps://library.ncl.res.in/content/controlling-stoichiometry-low-temperature-synthesis-la07sr03mno3-nanoparticles-002700nas a2200349 4500008004100000022001400041245011800055210006900173260000800242490000700250520161600257653000901873653001201882653001801894653002601912653001101938653001801949653001901967653001801986653002202004653002402026653001502050653001202065653002702077100002502104700002002129700002002149700002002169700001902189700001902208856012302227 2017 eng d a0928-493100aMultifunctional inulin tethered silver-graphene quantum dots nanotheranostic module for pancreatic cancer therapy0 aMultifunctional inulin tethered silvergraphene quantum dots nano cSEP0 v783 a

Cancer nanotechnology is an emerging area of cancer diagnosis and therapy. Although considerable progress has been made for targeted drug delivery systems to deliver anticancer agents to particular site of interest, new nanomaterials are frequently being developed and explored for better drug delivery efficiency. In the present work, we have explored a novel nanoformulation based on silver-graphene quantum dots (Ag-GQDs) nanocomposite for its successful implementation for pancreatic cancer specific drug delivery in wistar rats. Carboxymethyl inulin (CMI); a modified variant of natural polysaccharide inulin is tethered with the nanocomposite via carbodiimide coupling to enhance the biocompatibility of nanoformulation. Experiments are performed to investigate the cytotoxicity reduction of silver nanoparticles after inulin tethering as well as anticancer efficacy of the system using 5-Fluorouracil (5-FU) as model drug. SEM, TEM, FT-IR, UV-vis, photoluminescence and anti proliferative assays (MTT) are performed for characterisation of the nanocomposite. Hyaluronic acid (HA) is conjugated as targeting moiety for CD-44 (cancer stem cell marker) to fabricate a complete targeted drug delivery vehicle specific for pancreatic cancer. In the present work two prime objectives were achieved; mitigation the toxicity of silver nanoparticles by inulin coating and it's in vivo application for pancreatic cancer. (C) 2017 Elsevier B.V. All rights reserved.

10aacid10aDextran10aDrug-delivery10agraphene quantum dots10aInulin10aNanocomposite10aNanocomposites10aNanoparticles10aPancreatic Cancer10aSilver nanoparticle10aStrategies10aSystems10aTargeted Drug Delivery1 aJoshi, Preeti, Nigam1 aAgawane, Sachin1 aAgawane, Sachin1 aAgawane, Sachin1 aSarkar, Dhiman1 aSarkar, Dhiman uhttps://library.ncl.res.in/content/multifunctional-inulin-tethered-silver-graphene-quantum-dots-nanotheranostic-module02178nas a2200241 4500008004100000022001400041245011600055210006900171260000800240300001200248490000700260520139300267653001201660653001301672653001401685653002001699653001301719100002301732700001801755700002101773700001801794856012401812 2021 eng d a0959-810300aInjectabledextran-fluorenylmethoxycarbonylphenylalanine composite hydrogels with improved mechanical properties0 aInjectabledextranfluorenylmethoxycarbonylphenylalanine composite cFEB a222-2290 v703 a

Low molecular weight hydrogels are recently gaining importance owing to their applications in material sciences and biology. A new class of composite hydrogel was developed using polysaccharides such as dextran and fluorenylmethoxycarbonyl phenylalanine (FmocF) in a phosphate buffer. The molecular weight and concentration of the dextran were varied to obtain rigid but injectable hydrogels without using other crosslinking agents. From the different molecular weights of dextran studied (5k, 40k and 70k), a combination of FmocF (0.6% w/v) and dextran 40k (0.012% w/v) composite gels yielded a maximum value of storage modulus of approximately 1500 Pa, which is 3.5 times higher than the storage modulus of pure FmocF gels. Scanning electron microscopy of FmocF/dextran composite gels revealed highly tangled fibrous structures with dense branches and lower fiber diameter compared to pure FmocF gels. The high-intensity hydrogen-bonded N-H peak in the infrared spectra showed enhanced hydrogen bonding in FmocF/dextran composite gels compared to pure FmocF gels. The dextran acts as an impurity in the process of fibrillation, leading to a crystallographic mismatch, and densely packed thin fibers are formed. These gels exhibited gel to sol and sol to gel conversion with temperature or external stress and showed injectable behavior. (c) 2020 Society of Industrial Chemistry

10aDextran10aFmoc-Phe10ahydrogels10ainjectable gels10aRheology1 aAbraham, Jancy, N.1 aJoseph, Seena1 aTrivedi, Rishabh1 aKarle, Mrunal uhttps://library.ncl.res.in/content/injectabledextran-fluorenylmethoxycarbonylphenylalanine-composite-hydrogels-improved