02188nas a2200277 4500008004100000022001400041245013600055210006900191260011100260300001200371490000600383520117200389653001801561653001801579653000901597653001301606653001801619653001101637100001701648700002401665700002701689700003101716700002001747700001901767856012401786 2012 eng d a1573-413700aGreen approach towards size controlled synthesis of biocompatible antibacterial metal nanoparticles in aqueous phase using lysozyme0 aGreen approach towards size controlled synthesis of biocompatibl aEXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATESbBENTHAM SCIENCE PUBL LTDcFEB a130-1400 v83 a

Inspired by array of proteins present in nature, we choose lysozyme (hen egg protein) as a model system to synthesize nanoparticles of noble metals to understand the mechanism of interaction as well as to use them for potential applications such as potent antibacterial agents. Lysozyme is a very well studied biomolecule containing aromatic amino acids like tryptophan and tyrosine. Tyrosine has phenoxy group which is considered to be responsible for interacting with the metal ions. Lysozyme can be suitably modified by treatment with N-bromosuccinimide/N-acetylimidazole to obtain tight control over size distribution of nanoparticles. Here we report the direct synthesis of nanocrystals of gold and silver at controlled pH and light conditions without using any known reducing agents. Out of these, synthesis of gold nanoparticles is assisted by the presence of low concentration of Ag+ ions through the galvanic exchange. It is remarkable to note that the structure of protein is not changed drastically as seen by the FTIR studies. As-synthesized lysozyme capped nanoparticles prepared by this method are biocompatible and retain antibacterial property.

10aAntibacterial10aBiocompatible10aGold10alysozyme10aNanoparticles10aSilver1 aKumar, Umesh1 aRanjan, Amaresh, K.1 aSharan, Chandrashekhar1 aHardikar, Anandwardhan, A.1 aPundle, Archana1 aPoddar, Pankaj uhttps://library.ncl.res.in/content/green-approach-towards-size-controlled-synthesis-biocompatible-antibacterial-metal-002318nas a2200277 4500008004100000022001400041245015400055210006900209260007300278300001200351490000700363520129900370653001801669653002501687653000901712653001001721653001601731653003801747100002001785700002501805700002001830700002201850700002101872700002101893856012601914 2012 eng d a0927-776500aNovel route for rapid biosynthesis of copper nanoparticles using aqueous extract of Calotropis procera L. latex and their cytotoxicity on tumor cells0 aNovel route for rapid biosynthesis of copper nanoparticles using aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcJUN a284-2880 v953 a

This paper accounts for novel, low-cost, eco-friendly route for rapid biosynthesis of copper nanoparticles. Cysteine proteases present in the latex of Calotropis procera L. were used to fabricate copper nanoparticles from copper acetate. Copper nanoparticles were initially characterized by transmission electron microscopy (TEM) and X-ray diffraction technique (XRD). Transmission electron microscopy (TEM) was used to estimate the size and shape of nanoparticles. The average size of copper nanoparticles was found to be 15 +/- 1.7 nm. Energy dispersive analysis of X-rays (EDAX) showed distinct peaks of copper. Fourier transform infrared spectroscopy (FTIR) was performed to confirm capping behavior of the latex proteins that contributed to long term stability of copper nanoparticles (6 months) in aqueous medium. Copper nanoparticles synthesized by above method were monodisperse type. Cytotoxicity studies of latex stabilized copper nanoparticles were carried out on HeLa, A549 and BHK21 cell lines by MTT dye conversion assay. HeLa, A549 and BHK21 cells showed excellent viability even at 120 mu M concentration of copper nanoparticles. This shows that copper nanoparticles synthesized by above method hold excellent biocompatibility. (C) 2012 Elsevier B.V. All rights reserved.

10aBiocompatible10aCopper nanoparticles10aFTIR10aLatex10aTumor cells10aX-ray diffraction technique (XRD)1 aHarne, Shrikant1 aSharma, Ashwinikumar1 aDhaygude, Mayur1 aJoglekar, Shriram1 aKodam, Kisan, M.1 aHudlikar, Manish uhttps://library.ncl.res.in/content/novel-route-rapid-biosynthesis-copper-nanoparticles-using-aqueous-extract-calotropis-002563nas a2200265 4500008004100000022001400041245013200055210006900187260000900256300001000265490000700275520167700282653001801959653001501977653002201992653002702014653001302041100002202054700002102076700001602097700002402113700001702137700002202154856012102176 2015 eng d a0920-506300aFluorescent cadmium telluride quantum dots embedded chitosan nanoparticles: a stable, biocompatible preparation for bio-imaging0 aFluorescent cadmium telluride quantum dots embedded chitosan nan cJAN  a42-560 v263 a

Fluorescent cadmium telluride quantum dots (CdTe QDs) are an optically attractive option for bioimaging, but are known to display high cytotoxicity. Nanoparticles synthesized from chitosan, a natural biopolymer of beta 1-4 linked glucosamine, display good biocompatibility and cellular uptake. A facile, green synthetic strategy has been developed to embed green fluorescent cadmium telluride quantum dots (CdTe QDs) in biocompatible CNPs to obtain a safer preparation than `as is' QDs. High-resolution transmission electron microscopy showed the crystal lattice corresponding to CdTe QDs embedded in CNPs while thermogravimetry confirmed their polymeric composition. Electrostatic interactions between thiol-capped QDs (4nm, -57mV) and CNPs (\~300nm, +38mV) generated CdTe QDs-embedded CNPs that were stable up to three months. Further, viability of NIH3T3 mouse fibroblast cells in vitro increased in presence of QDs-embedded CNPs as compared to bare QDs. At the highest concentration (10 mu g/ml), the former shows 34 and 39% increase in viability at 24 and 48h, respectively, as compared to the latter. This shows that chitosan nanoparticles do not release the QDs up to 48h and do not cause extended toxicity. Furthermore, hydrolytic enzymes such as lysozyme and chitinase did not degrade chitosan nanoparticles. Moreover, QDs-embedded CNPs show enhanced internalization in NIH3T3 cells as compared to bare QDs. This method offers ease of synthesis and handling of stable, luminescent, biocompatible CdTe QDs-embedded CNPs with a favorable toxicity profile and better cellular uptake with potential for bioimaging and targeted detection of cellular components.

10aBiocompatible10abioimaging10aCdTe quantum dots10achitosan nanoparticles10aToxicity1 aGhormade, Vandana1 aGholap, Haribhau1 aKale, Sonia1 aKulkarni, Vaishnavi1 aBhat, Suresh1 aPaknikar, Kishore uhttps://library.ncl.res.in/content/fluorescent-cadmium-telluride-quantum-dots-embedded-chitosan-nanoparticles-stable02321nas a2200241 4500008004100000022001400041245005900055210005800114260000800172300001400180490000800194520161100202653001801813653001801831653001801849653001301867653002501880653002001905100002001925700002101945700002001966856009301986 2019 eng d a1364-507200aPolylactic acid: synthesis and biomedical applications0 aPolylactic acid synthesis and biomedical applications cDEC a1612-16260 v1273 a

Social and economic development has driven considerable scientific and engineering efforts on the discovery, development and utilization of polymers. Polylactic acid (PLA) is one of the most promising biopolymers as it can be produced from nontoxic renewable feedstock. PLA has emerged as an important polymeric material for biomedical applications on account of its properties such as biocompatibility, biodegradability, mechanical strength and process ability. Lactic acid (LA) can be obtained by fermentation of sugars derived from renewable resources such as corn and sugarcane. PLA is thus an eco-friendly nontoxic polymer with features that permit use in the human body. Although PLA has a wide spectrum of applications, there are certain limitations such as slow degradation rate, hydrophobicity and low impact toughness associated with its use. Blending PLA with other polymers offers convenient options to improve associated properties or to generate novel PLA polymers/blends for target applications. A variety of PLA blends have been explored for various biomedical applications such as drug delivery, implants, sutures and tissue engineering. PLA and their copolymers are becoming widely used in tissue engineering for function restoration of impaired tissues due to their excellent biocompatibility and mechanical properties. The relationship between PLA material properties, manufacturing processes and development of products with desirable characteristics is described in this article. LA production, PLA synthesis and their applications in the biomedical field are also discussed.

10aBiocompatible10abiodegradable10adrug delivery10aimplants10al- and d-lactic acid10apolylactic acid1 aSinghvi, M., S.1 aZinjarde, S., S.1 aGokhale, D., V. uhttps://library.ncl.res.in/content/polylactic-acid-synthesis-and-biomedical-applications01782nas a2200277 4500008004100000022001400041245011400055210006900169260000800238300001000246490000700256520088900263653001801152653000901170653002101179653001001200653002901210653002701239653001501266653001601281100001701297700001801314700002001332700002701352856012501379 2020 eng d a0019-559600aMagnetic and luminescent multifunctional nanohybrid: Fe3O4@CaF2:Tb3+: a facile synthesis and characterization0 aMagnetic and luminescent multifunctional nanohybrid Fe3O4CaF2Tb3 cJAN a31-350 v583 a

In the present study, bi-functional hybrid nanomaterial has been synthesized and characterized via facile method and characterized. The synthesized nanomaterial shows both magnetic and luminescent properties which are confirmed by VSM (vibrating sample magnetometer), UV-Vis spectra and the photoluminescence emission spectra. For the magnetic phase, i.e., nanocrystalline magnetite, Fe3O4 is used as the core which is then functionalized using polyethylene glycol (PEG) and for the luminescent phase, polyethylenimine (PEI) functionalized CaF2 doped with Tb3+ is used as the emitter. Wherein, both PEG and PEI serve the dual purpose of functionalization as well as stabilization by steric repulsion. The structure and morphology of the synthesized bifunctional hybrid nanomaterial are studied with the help of scanning electron microscopy (SEM) and X-ray powder diffraction.

10aBiocompatible10aCaF210aCo-precipitation10aFe3O410aLuminescent nanoparticle10aMagnetic nanoparticles10aNanohybrid10aTb3+ doping1 aVats, Monika1 aKumar, Rakesh1 aSharma, Jyotsna1 aLuwang, Meitram, Niraj uhttps://library.ncl.res.in/content/magnetic-and-luminescent-multifunctional-nanohybrid-fe3o4caf2tb3-facile-synthesis-and01460nas a2200217 4500008004100000022001400041245009900055210006900154260000900223300001200232490000700244520071700251653001800968653002800986653001301014653000901027653002801036100002301064700002801087856012701115 2020 eng d a1023-666X00aSynthesis and characterization of biocompatible poly (L-lactide) using zinc (II) salen complex0 aSynthesis and characterization of biocompatible poly Llactide us cJUL  a283-2990 v253 a

A biocompatible zinc (II) complex based on a tetradentate N,N,O,O-type salen ligand was synthesized, characterized and used for the solvent-free ring-opening polymerization (ROP) of L-lactide in bulk at 180 degrees C to prepare high molecular weight poly(L-lactide) (M-n: 82,600 Da;M-w: 140,000 Da; PDI: 1.70). Poly(L-lactide) (PLLA) was characterized using FTIR,H-1 NMR,C-13 NMR, GPC, TGA, DSC, WAXD, and MALDI-ToF. Kinetic measurement was carried out and first-order behavior to monomer was observed. Thek(app)was found as 6 +/- 0.001 x 10(-4 )s(-1). The biocompatibility of the PLLA was confirmed byin vitrocytotoxicity against NIH/3T3 fibroblast cell line and can be used in biomedical applications.

10aBiocompatible10aBiomedical Applications10ain vitro10aPLLA10azinc (II) salen complex1 aRade, Priyanka, P.1 aGarnaik, Baijayantimala uhttps://library.ncl.res.in/content/synthesis-and-characterization-biocompatible-poly-l-lactide-using-zinc-ii-salen-complex