02509nas a2200325   4500008004100000022001400041245009900055210006900154260009200223300001200315490000600327520135500333653001001688653001601698653002301714653001001737653002201747100002301769700003101792700003101823700002701854700002501881700002201906700001901928700002301947700002301970700002501993700003302018856013202051       2012                        eng d  a2158-584900aFluorescent superparamagnetic iron oxide core-shell nanoprobes for multimodal cellular imaging0 aFluorescent superparamagnetic iron oxide coreshell nanoprobes fo  a26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USAbAMER SCIENTIFIC PUBLISHERScDEC  a265-2740 v23 a<p>Multimodal imaging agents that combine magnetic and fluorescent imaging capabilities are desirable for the high spatial and temporal resolution. In the present work, we report the synthesis of multifunctional fluorescent ferrofluids using iron oxide as the magnetic core and rhodamine B as fluorochrome shell. The core-shell structure was designed in such a way that fluorescence quenching due to the inner magnetic core was minimized by an intermediate layer of silica. The intermediate passive layer of silica was realized by a novel method which involves the esterification reaction between the epoxy group of prehydrolysed 3-Glyidoxypropyltrimethoxysilane and the surfactant over iron oxide. The as-synthesized ferrofluids have a high saturation magnetization in the range of 62-65 emu/g and were found to emit light of wavelength 640 nm (lambda(excitation) = 446 nm). Time resolved life time decay analysis showed a bi-exponential decay pattern with an increase in the decay life time in the presence of intermediate silica layer. Cytotoxicity studies confirmed the cell viability of these materials. The in vitro MRI imaging illustrated a high contrast when these multimodal nano probes were employed and the R2 relaxivity of these sample was found to be 334 mM(-1)s(-1) which reveals its high potential as a T2 contrast enhancing agent.</p>10aGPTMS10aMRI Imaging10aMultimodal Imaging10aSPION10aT2 Contrast Agent1 aSmitha, Sasidharan1 aHaseena, Vadakkenchery, S.1 aNarayanan, Tharangattu, N.1 aMary, Antony, P. Reena1 aAjayan, Pulickel, M.1 aPuthumana, Jayesh1 aAziz, Anas, A.1 aAburto, Rebeca, R.1 aMani, Sendurai, A.1 aJoy, Pattayil, Alias1 aAnantharaman, Maliemadom, R.  uhttps://library.ncl.res.in/content/fluorescent-superparamagnetic-iron-oxide-core-shell-nanoprobes-multimodal-cellular-imaging-002198nas a2200253   4500008004100000022001400041245010700055210006900162260000800231300001100239490000800250520133700258653001801595653001801613653001901631653002301650100001901673700002301692700002001715700002301735700002301758700003201781856013101813       2025                        eng d  a1552-497300aGold nanorods (GNRs): a golden nano compass to navigate breast cancer by multimodal imaging approaches0 aGold nanorods GNRs a golden nano compass to navigate breast canc  cFEB  ae355430 v1133 a<p>
	The ongoing rise in the incidences of breast cancer cases has concerned medical and scientific personnel around the world. Adequate treatment of cancer predominantly relies on the pertinent diagnosis of the type of cancer as well as other molecular and cellular details at the initial stage only. Surprisingly, up till now, there is no single, self-reliant imaging modality that helps to systematically find out the anatomical and functional events taking place inside the body. This resulted in the advent of the multimodal imaging concept, which encompasses the integration of complementary imaging modalities by designing multimodal imaging probes. Gold nanorods (GNRs) are extremely popular and effective nanoparticles for multimodal bioimaging due to their unique properties. Researchers have designed varieties of stable and biocompatible GNR-based probes for targeted and nontargeted multimodal imaging of breast cancer. However, there is a lack of investigations on the in vivo fate and the toxicity of GNRs. Thus, their preclinical to clinical translation can be attained by comprehensively determining the in vivo fate and toxicity of GNRs. The review provides details about the GNRs-based nanoprobes fabricated so far for breast cancer imaging, which, by consequent studies, can be taken up to clinical usage.</p>
10aBreast cancer10aGold nanorods10aimaging probes10aMultimodal Imaging1 aVarma, Sanjana1 aBamb, Aagam, Lalit1 aHaldar, Niladri1 aGajbhiye, Virendra1 aAmalnerkar, Dinesh1 aChaudhari, Bhushan, Pradosh  uhttps://library.ncl.res.in/content/gold-nanorods-gnrs-golden-nano-compass-navigate-breast-cancer-multimodal-imaging-approaches