01485nas a2200217   4500008004100000022001400041245011700055210006900172260007300241300001200314490000600326520068400332653001801016653001401034653001801048653001701066653001501083100001901098700001901117856013101136       2008                        eng d  a1566-736700aNovel method for the protection of amino alcohols and carbonyl compounds over a heterogeneous, reusable catalyst0 aNovel method for the protection of amino alcohols and carbonyl c  aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcMAR  a645-6490 v93 a<p>A novel application of Al-SBA-15 catalyst in the protection of amino alcohols and carbonyl compounds is reported. N-t-butoxy carbonyl [N(Boc)] amino alcohols were protected using 2,2-dimethoxyproparic (DMP) to form acetonides. Acetonide deprotection was also studied using the same catalyst to obtain the parent amino alcohol. Protection of carbonyl compounds was Studied using neopentyl glycol, ethylene glycol and propylene glycol as the protecting agents. A series of commercially important molecules Such as 2-substituted and 2,2-disubstituted 1,3-benzodioxoles were synthesized by reacting carbonyl compounds with catechol. (c) 2007 Elsevier B.V. All rights reserved.</p>10aAcetalization10aacetonide10aAmino alcohol10abenzodioxole10aprotection1 aSrivastava, P.1 aSrivastava, R.  uhttps://library.ncl.res.in/content/novel-method-protection-amino-alcohols-and-carbonyl-compounds-over-heterogeneous-reusable-001569nas a2200253   4500008004100000022001400041245019000055210006900245260010600314300001400420490000700434520053900441653002000980653002501000653002401025653001801049653001201067100001701079700003201096700002201128700002601150700002201176856011701198       2010                        eng d  a0040-403900aFacile enantioselective synthesis of (S)-N-(5-chlorothiophene-2-sulfonyl)-beta,beta-diethylalaninol via proline-catalyzed asymmetric alpha-aminooxylation and alpha-amination of aldehyde0 aFacile enantioselective synthesis of SN5chlorothiophene2sulfonyl  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcDEC  a6565-65670 v513 a<p>A high-yielding enantioselective synthesis of the bioactive (S)-N-(5-chlorothiophene-2-sulfonyl)beta,beta-diethylalaninol (1), a Notch-1-sparing gamma-secretase inhibitor metabolite (with EC50 = 28 nM) effective in reduction of All production in vivo, has been realized starting from readily available 3-pentanone. The key steps of the synthesis are proline-catalyzed alpha-aminooxylation and alpha-amination of aldehyde: the latter contributing an overall yield of 45.2% and 98% ee. (C) 2010 Elsevier Ltd. All rights reserved.</p>10aalpha-Amination10aalpha-Aminooxylation10aAlzheimer's disease10aAmino alcohol10aProline1 aRawat, Varun1 aChouthaiwale, Pandurang, V.1 aChavan, Vilas, B.1 aSuryavanshi, Gurunath1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/facile-enantioselective-synthesis-s-n-5-chlorothiophene-2-sulfonyl-betabeta-000874nas a2200217   4500008004100000022001400041245005300055210004900108260007500157300001200232520015600244653001800400653001600418653003600434653001400470653003000484100002000514700002000534700001900554856008300573       2011                        eng d  a0039-788100aStereoselective synthesis of (-)-galantinic acid0 aStereoselective synthesis of galantinic acid  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcMAR  a901-9043 a<p>An efficient and highly concise synthesis of (-)-galantinic acid has been achieved using an asymmetric allylation reaction of Garner's aldehyde.</p>10aAmino alcohol10aChiral pool10aiterative asymmetric allylation10aOxidation10astereoselective synthesis1 aDubey, Abhishek1 aHarbindu, Anand1 aKumar, Pradeep  uhttps://library.ncl.res.in/content/stereoselective-synthesis-galantinic-acid-001354nas a2200241   4500008004100000022001400041245009000055210006900145260010600214300001400320490000700334520044400341653001800785653002800803653003100831653001900862100002200881700002400903700001900927700001500946700002700961856012400988       2013                        eng d  a0960-894X00aSynthesis and antitubercular activity of amino alcohol fused spirochromone conjugates0 aSynthesis and antitubercular activity of amino alcohol fused spi  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAR  a1416-14190 v233 a<p>A series of 21 new amino alcohol fused spirochromone conjugates have been synthesized, characterized with analytical data and evaluated their antimycobacterial activity against Mycobacterium tuberculosis (virulent strain H37Rv) in vitro. Some of the compounds exerted significant inhibition, in particular, compound 4f found to be the most potent derivative exhibiting MIC = 3.13 mu g/mL. (C) 2013 Elsevier Ltd. All rights reserved.</p>10aAmino alcohol10aAntitubercular activity10aMycobacterium tuberculosis10aSpirochromones1 aMujahid, Mohammad1 aGonnade, Rajesh, G.1 aYogeeswari, P.1 aSriram, D.1 aMuthukrishnan, Murugan  uhttps://library.ncl.res.in/content/synthesis-and-antitubercular-activity-amino-alcohol-fused-spirochromone-conjugates-0