02190nas a2200277   4500008004100000022001400041245007700055210006900132260007300201300001200274490000800286520122600294653003401520653002401554653001801578653001401596653002901610653002001639653003201659653002301691100002301714700002401737700002401761700001901785856010801804       2010                        eng d  a0921-510700aRing opening polymerization of dilactide using salen complex as catalyst0 aRing opening polymerization of dilactide using salen complex as   aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcAPR  a193-1980 v1683 a<p>The recent concerns about our environment have led to search for environmentally benign and sustainable materials that could substitute the more commonly used petroleum based materials. Biodegradable and sustainable polylactide (PLA) is becoming one of the most promising and practical materials as a partial replacement for the petroleum-based materials. The commercially available PLA is generally homochiral poly(L-lactide) (PLLA) at present because L-lactic acid with high optical purity can only be obtained in bulk by fermentation of carbohydrate. PLLA is mostly synthesized by ring opening polymerization (ROP) of homochiral L-lactide (LLA), which is a cyclic dimer of L-lactic acid. In the present work, poly(L-lactide)s were synthesized by the ring opening polymerization (ROP) of L-lactide using iron and manganese salen complexes as catalyst. The new iron and manganese salen complexes were synthesized, purified, characterized and used as catalyst for polymerization of L-lactide. The poly(L-lactide)s prepared were characterized by infrared, proton NMR spectroscopy, solution viscosity, gel permeation chromatography, thermal analysis and X-ray diffraction. (C) 2009 Elsevier B.V. All rights reserved.</p>10aGel permeation chromatography10aIron salen catalyst10aL-Lactic acid10aL-Lactide10aManganese salen catalyst10aPoly(L-lactide)10aring opening polymerization10aSolution viscosity1 aIdage, Bhaskar, B.1 aIdage, Susheela, B.1 aKasegaonkar, A., S.1 aJadhav, R., V.  uhttps://library.ncl.res.in/content/ring-opening-polymerization-dilactide-using-salen-complex-catalyst-002234nas a2200253   4500008004100000022001400041245021300055210006900268260006700337300001400404490000700418520117300425653004101598653002001639653002401659653003201683100002201715700002601737700002301763700001901786700002101805700002801826856012601854       2013                        eng d  a0887-624X00aFacile strategy for synthesis of ,-heterobifunctionalized poly (epsilon-caprolactones) and poly (methyl methacrylate)s containing ``clickable'' aldehyde and allyloxy functional groups using initiator approach0 aFacile strategy for synthesis of heterobifunctionalized poly eps  a111 RIVER ST, HOBOKEN 07030-5774, NJ USAbWILEY-BLACKWELLcMAY  a2091-21030 v513 a<p>Two new initiators, namely, 4-(4-(2-(4-(allyloxy) phenyl)-5-hydroxypentane 2-yl) phenoxy)benzaldehyde and 4-(4-(allyloxy) phenyl)-4-(4-(4-formylphenoxy) phenyl) pentyl 2-bromo-2-methyl propanoate containing clickable hetero-functionalities namely aldehyde and allyloxy were synthesized starting from commercially available 4,4-bis(4-hydroxyphenyl) pentanoic acid. These initiators were utilized, respectively, for ring opening polymerization of epsilon-caprolactone and atom transfer radical polymerization of methyl methacrylate. Well-defined -aldehyde, -allyloxy heterobifunctionalized poly(epsilon-caprolactones) (Mn,GPC: 590029,000, PDI: 1.261.43) and poly(methyl methacrylate)s (Mn,GPC: 530028800, PDI: 1.191.25) were synthesized. The kinetic study of methyl methacrylate polymerization demonstrated controlled polymerization behavior. The presence of aldehyde and allyloxy functionality on polymers was confirmed by 1H NMR spectroscopy. Aldehyde-aminooxy and thiol-ene metal-free double click strategy was used to demonstrate reactivity of functional groups on polymers. (c) 2013 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013, 51, 2091-2103</p>10aatom transfer radical polymerization10aClick chemistry10afunctional polymers10aring opening polymerization1 aSane, Prakash, S.1 aTawade, Bhausaheb, V.1 aParmar, Indravadan1 aKumari, Savita1 aNagane, Samadhan1 aWadgaonkar, Prakash, P.  uhttps://library.ncl.res.in/content/facile-strategy-synthesis-heterobifunctionalized-poly-epsilon-caprolactones-and-poly-002260nas a2200217   4500008004100000022001400041245015500055210006900210260000800279300001400287490000700301520143400308653001301742653003201755653003201787653002101819653001901840100002601859700002801885856012901913       2021                        eng d  a1042-714700aEvaluation of biocompatibility of synthesized low molecular weight PLGA copolymers using zinc L-proline through green route for biomedical application0 aEvaluation of biocompatibility of synthesized low molecular weig  cNOV  a4502-45150 v323 aPoly(lactide-co-glycolide) (PLGA) copolymers were synthesized by ring opening polymerization in presence of zinc proline and stannous octoate in bulk through green route and were designated as PLGA-1 and PLGA-2 respectively. These copolymers were characterized using NMR, SEC, DSC, X-ray and MALDI-TOF analysis. For the first time, the low molecular weight of PLGA (similar to 11,000 Da) was mainly targeted to explore acute oral toxicity in the presence of zinc L-proline and stannous octoate. The haemolysis and cell viability assay were carried out for in-vitro cytotoxicity assessment. Haemolysis assay of PLGA-2 was confirmed and haemolytic potential exceeded limit of American society of testing of material standard. The cell viability study using fibroblast cell lines (NIH3T3), exhibited statistically significant difference in results between PLGA-1 and PLGA-2. The acute toxicity study was performed in Balb/c mice for biomarker, hematological and histopathological analysis. No mortality was observed during the entire observation period, and no macroscopic change of the organs was observed in PLGA-1 treated group where PLGA-2 treated group showed sign of toxicity. The results obtained from in-vitro and in-vivo studies suggested that PLGA-2 was toxic whereas PLGA-1 was nontoxic in nature. Therefore, PLGA-1 can be regarded as biocompatible biomaterials for potential for drug delivery and biomedical application.10aOECD-42010apoly (lactide-co-glycolide)10aring opening polymerization10aStannous octoate10azinc L-Proline1 aGiram, Prabhanjan, S.1 aGarnaik, Baijayantimala  uhttps://library.ncl.res.in/content/evaluation-biocompatibility-synthesized-low-molecular-weight-plga-copolymers-using-zinc-l