02030nas a2200217   4500008004100000022001400041245011300055210006900168260007300237300001000310490000700320520120200327653001901529653001301548653001801561653002701579653003301606100002101639700002001660856013201680       2012                        eng d  a0141-813000aGlycolic acid-g-chitosan-Pt-Fe3O4 nanoparticles nanohybrid scaffold for tissue engineering and drug delivery0 aGlycolic acidgchitosanPtFe3O4 nanoparticles nanohybrid scaffold   aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcJUL  a76-820 v513 a<p>This work presents the potential use of novel nanohybrid based on chitosan-g-glycolic acid and Pt-Fe3O4 composite nanoparticles in drug delivery and tissue engineering applications. The Pt-Fe3O4 hybrid nanoparticles are prepared by thermal decomposition of H2PtCl6 center dot 6H(2)O at high temperature. The prepared nanoparticles were characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and physical property measurement system (PPMS). Next step of this paper reveals the potential use of novel hybrids of chitosan-g-glycolic acid and Pt-Fe3O4 hybrid nanoparticles in controlled drug delivery applications. The drug loaded nanohybrid scaffold is prepared by freeze drying of grafted polymer solution. Drug loading and grafting of chitosan was characterized by Fourier transform infrared spectroscopy (FTIR). The cell proliferation also shows that the prepared nanohybrids are biocompatible. The nanohybrid was found to be stable regardless of pH of the medium. Therefore, Pt-Fe3O4 hybrid nanoparticles are viable additive for sustained drug delivery and it could be applied in the field of biomedical. (c) 2012 Elsevier B.V. All rights reserved.</p>10aCell viability10aChitosan10adrug delivery10aGlycolic acid grafting10aPt-Fe3O4 hybrid nanoparticle1 aKumari, Sangeeta1 aSingh, Raj, Pal  uhttps://library.ncl.res.in/content/glycolic-acid-g-chitosan-pt-fe3o4-nanoparticles-nanohybrid-scaffold-tissue-engineering-and-002065nas a2200241   4500008004100000022001400041245014800055210006900203260010600272300001200378490000800390520114400398653001901542653001101561653001701572653001801589653001101607100001501618700002301633700002101656700001701677856012901694       2013                        eng d  a1386-142500aBiological synthesis of silver nanoparticles using the fungus humicola sp and evaluation of their cytoxicity using normal and cancer cell lines0 aBiological synthesis of silver nanoparticles using the fungus hu  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcOCT  a144-1470 v1143 a<p>Nanoscience is a new born science of the modern era and taps into the potential of particles at nanoscale. Bulk materials reduced to nanoscale dimensions thus obtain unique properties such as electronic, optical, magnetic and chemical. As far as synthesis of nanoparticles is concerned, biological synthesis has recently sparked a great interest as compared to other available chemical and physical methods on account of its eco-friendliness and cost-effectiveness. Here we report, for the first time, the biosynthesis of silver nanoparticles by the thermophilic fungus Humicola sp. The fungus when reacted with Ag+ ions reduces the precursor solution and leads to the formation of extracellular nanoparticles as monitored by ultra violet visible spectroscopy (UV-Vis). The morphology of nanoparticles is found to be spherical with good dispersity as revealed by transmission electron microscopy (TEM). Cell viability assays were carried out to assess the cytotoxicity of silver nanoparticles on NIH3T3 mouse embryonic fibroblast cell line and MDA-MB-231 human breast carcinoma cell line. (C) 2013 Elsevier B.V. All rights reserved.</p>10aCell viability10aFungus10aHumicola sp.10aNanoparticles10aSilver1 aSyed, Asad1 aSaraswati, Supriya1 aKundu, Gopal, C.1 aAhmad, Absar  uhttps://library.ncl.res.in/content/biological-synthesis-silver-nanoparticles-using-fungus-humicola-sp-and-evaluation-their-002327nas a2200253   4500008004100000022001400041245008200055210006900137260000900206300001200215490000700227520152500234653001801759653001901777653001701796653001501813653002101828653001801849100002201867700002201889700002201911700002701933856011301960       2015                        eng d  a0928-493100aBioactive thermoresponsive polyblend nanofiber formulations for wound healing0 aBioactive thermoresponsive polyblend nanofiber formulations for   cMAR   a126-1370 v483 a<p>The rationale of this work is to develop new bioactive thermoresponsive polyblend nanofiber formulations for wound healing (topical). Various polymer compositions of thermoresponsive, poly(N-isopropylacrylamide), egg albumen and poly(epsilon-caprolactone) blend solutions with and without a drug [gatifloxacin hydrochloride, Gati] were prepared. Non-woven nanofibers of various compositions were fabricated using an electrospinning technique. The morphology of the nanofibers was analyzed by an environmental scanning electron microscope. The morphology was influenced by the concentration of polymer, drug, and polymer blend composition. Fourier transform infrared spectroscopy analysis showed the shift in bands due to hydrogen ion interactions between polymers and drug. Thermogram of PNIPAM/PCL/EA with Gati recorded a shift in lower critical solution temperature (LCST) and glass transition temperature (T-g) of PNIPAM. Similarly T-g and melting temperature (T-m) of PCL were shifted. X-ray diffraction patterns recorded a decrease in the crystalline state of PCL nanofibers and transformed crystalline drug to an amorphous state. In vitro release study of nanofibers with Gati showed initial rapid release up to 10 h, followed by slow and controlled release for 696 h (29 days). Nanofiber mats with Gati exhibited antibacterial properties to Staphylococcus aureus, supported suitable controlled drug release with in vitro cell viability and in vivo wound healing. (C) 2014 Elsevier B.V. All rights reserved.</p>10aAntibacterial10aCell viability10adrug release10ananofibers10athermoresponsive10awound Healing1 aPawar, Mahesh, D.1 aRathna, G., V. N.1 aAgrawal, Shubhang1 aKuchekar, Bhanudas, S.  uhttps://library.ncl.res.in/content/bioactive-thermoresponsive-polyblend-nanofiber-formulations-wound-healing01677nas a2200265   4500008004100000022001400041245009800055210006900153260008600222300001400308490000700322520074600329653001901075653001801094653001801112653001701130653001001147100002101157700002601178700001601204700001801220700002901238700002601267856011801293       2016                        eng d  a0737-393700aEncapsulation of yeast (Saccharomyces cereviciae) by spray drying for extension of shelf life0 aEncapsulation of yeast Saccharomyces cereviciae by spray drying   a530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USAbTAYLOR & FRANCIS INCcJAN  a1307-13180 v343 a<p>The objective of the present work was to encapsulate yeast using different carrier materials and examine their efficacy in retaining viability of cells after spray drying. Slurry containing yeast cells along with known amount of carrier material (maltodextrin, corn starch, gum arabic, acacia gum, polyethylene glycol 8000, -cyclodextrin, and skimmed milk powder, one at a time) was added and served as feed. Among these carrier materials attempted, corn starch and maltodextrin showed the best results with respect to powder yield (59%, w/w) and cell survival (80.5%), respectively. However, considering both survival and powder yield (67 and 59% w/w, respectively), corn starch was observed to be the most suitable carrier material.</p>10aCell viability10aEncapsulation10afreeze-drying10aspray drying10aYeast1 aChandralekha, A.1 aTavanandi, Hrishikesh1 aAmrutha, N.1 aHebbar, Umesh1 aRaghavarao, K., S. M. S.1 aGadre, Ramchandra, V.  uhttps://library.ncl.res.in/content/encapsulation-yeast-saccharomyces-cereviciae-spray-drying-extension-shelf-life