02108nas a2200253 4500008004100000022001400041245015000055210006900205260007300274300001200347490000700359520113700366653003801503653000901541653002101550653001601571653000801587100002201595700002601617700003001643700002201673700002801695856013101723 2012 eng d a1381-514800aAromatic aldehyde functionalized polycaprolactone and polystyrene macromonomers: synthesis, characterization and aldehyde-aminooxy click reaction0 aAromatic aldehyde functionalized polycaprolactone and polystyren aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcOCT a713-7210 v723 a

New bis-aldehyde functionalized initiators, viz, 4,4'-(4,4'-(5-hydroxypentane-2,2-diyl)bis(4,1-phenylene))bis(oxy)dibenza ldehyde (1) and 4,4'-bis(4-(4-(formylphenoxy) phenyl) pentyl 2-bromopropanoate (2) were synthesized starting from commercially available 4,4'-bis(4-hydroxyphenyl) pentanoic acid. These initiators were utilized, respectively, for ring opening polymerization of E-caprolactone and atom transfer radical polymerization of styrene. Well-defined polycaprolactone macromonomers (M-n(GPC): 2600-19400, PDI: 1.37-1.47) and polystyrene macromonomers (M-n(GPC): 2800-28200, PDI: 1.11-1.16) with bis-aldehyde functionality were synthesized. The kinetic study of styrene polymerization showed controlled polymerization behaviour. The presence of aldehyde functionality in macromonomers was confirmed by H-1 NMR spectroscopy. The reactivity of aldehyde functionality was demonstrated by carrying out aldehyde-aminooxy click reaction of polycaprolactone macromonomer with O-(2-azidoethyl) hydroxylamine which proceeded in a quantitative manner without backbone degradation. (C) 2012 Elsevier Ltd. All rights reserved.

10aAldehyde-terminated macromonomers10aATRP10aPolycaprolactone10aPolystyrene10aROP1 aSane, Prakash, S.1 aTawade, Bhausaheb, V.1 aPalaskar, Dnyaneshwar, V.1 aMenon, Shamal, K.1 aWadgaonkar, Prakash, P. uhttps://library.ncl.res.in/content/aromatic-aldehyde-functionalized-polycaprolactone-and-polystyrene-macromonomers-synthesis-002242nas a2200313 4500008004100000022001400041245013900055210006900194260010600263300001000369490000700379520108700386653002701473653001601500653002001516653001501536653001901551653002101570100002101591700002001612700002801632700002501660700002401685700002101709700002801730700002201758700002001780856012801800 2014 eng d a0014-305700aPolystyrene/TiO2 composite electrospun fibers as fillers for poly(butylene succinate-co-adipate): Structure, morphology and properties0 aPolystyreneTiO2 composite electrospun fibers as fillers for poly aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJAN a78-860 v503 a

In this work, composite polystyrene/titanium dioxide (PS/TiO2) electrospun fibers were used as a reinforcement for a poly(butylene succinate-co-adipate) (PBSA) matrix. The structure, morphology, mechanical properties and degradation behavior of such materials were investigated, finding that, as a function of their TiO2 content, the fibers exerted different effects. The main mechanism through which the fibers modified the structure and morphology of the polymer matrix is by altering its crystallization kinetics. The presence of TiO2 modified the roughness of the fibers and therefore affected the interfacial adhesion between the filler and the matrix. The modulus of PBSA was improved, even though the brittleness of the materials was increased by the presence of the fibers. Different amounts of TiO2 within the fibers allowed to tune the hydrolytic degradation rate of the composites. This paper shows the potential of using composite electrospun fibers as effective fillers for the preparation of polymer-based composites. (C) 2013 Elsevier Ltd. All rights reserved.

10aBiodegradable polymers10aDegradation10aelectrospinning10aMorphology10aNanocomposites10aPolycaprolactone1 aNeppalli, Ramesh1 aCausin, Valerio1 aBenetti, Edmondo, Maria1 aRay, Suprakas, Sinha1 aEsposito, Antonella1 aWanjale, Santosh1 aBirajdar, Mallinath, S.1 aSaiter, Jean-Marc1 aMarigo, Antonio uhttps://library.ncl.res.in/content/polystyrenetio2-composite-electrospun-fibers-fillers-polybutylene-succinate-co-adipate-002769nas a2200229 4500008004100000245012000041210006900161260000800230300001100238490000800249520195200257653002702209653001502236653003002251653002102281100002102302700001702323700002602340700002002366700002702386856012602413 2024 eng d00aBiodegradable and 3D printable lysine functionalized polycaprolactone scaffolds for tissue engineering applications0 aBiodegradable and 3D printable lysine functionalized polycaprola cMAY a2138160 v1593 a

Tissue engineering (TE) has sparked interest in creating scaffolds with customizable properties and functional bioactive sites. However, due to limitations in medical practices and manufacturing technologies, it is challenging to replicate complex porous frameworks with appropriate architectures and bioactivity in vitro. To address these challenges, herein, we present a green approach that involves the amino acid (L-lysine) initiated polymerization of epsilon-caprolactone (CL) to produce modified polycaprolactone (PCL) with favorable active sites for TE applications. Further, to better understand the effect of morphology and porosity on cell attachment and proliferation, scaffolds of different geometries with uniform and interconnected pores are designed and fabricated, and their properties are evaluated in comparison with commercial PCL. The scaffold morphology and complex internal micro-architecture are imaged by micro-computed tomography (micro-CT), revealing pore size in the range of similar to 300-900 mu m and porosity ranging from 30 to 70 %, while based on the geometry of scaffolds the compressive strength varied from 143 +/- 19 to 214 +/- 10 MPa. Additionally, the degradation profiles of fabricated scaffolds are found to be influenced by both the chemical nature and product design, where Lys-PCL-based scaffolds with better porosity and lower crystallinity degraded faster than commercial PCL scaffolds. According to in vitro studies, Lys-PCL scaffolds have produced an environment that is better for cell adhesion and proliferation. Moreover, the scaffold design affects the way cells interact; Lys-PCL with zigzag geometry has demonstrated superior in vitro vitality (>90 %) and proliferation in comparison to other designs. This study emphasizes the importance of enhancing bioactivity while meeting morphology and porosity requirements in the design of scaffolds for tissue engineering applications.

10aAdditive manufacturing10aAmino acid10aMicro-computed tomography10aPolycaprolactone1 aNaik, Sonali, S.1 aTorris, Arun1 aChoudhury, Namita, R.1 aDutta, Naba, K.1 aNair, Kiran, Sukumaran uhttps://library.ncl.res.in/content/biodegradable-and-3d-printable-lysine-functionalized-polycaprolactone-scaffolds-tissue02613nas a2200229 4500008004100000022001400041245016000055210006900215260000800284300001100292490000700303520173900310653002802049653002102077653003302098653003202131653001902163100002102182700002402203700002702227856012902254 2025 eng d a1042-714700aOptimization and mechanistic insights of zinc ascorbate catalyst for ring-opening polymerization of caprolactone using RSM methodology and DFT calculations0 aOptimization and mechanistic insights of zinc ascorbate catalyst cAPR ae701820 v363 a

Polycaprolactone (PCL) is an aliphatic polyester recognized for its exceptional versatility and biodegradability, which has garnered significant attention for a wide range of applications. This study presents an innovative methodology for the synthesis of PCL through the ring-opening polymerization (ROP) of epsilon-caprolactone (CL). The approach employs a biocompatible and environmentally benign organometallic zinc ascorbate complex as a catalyst. Derived from ascorbic acid, a well-established reducing agent, zinc ascorbate serves as a sustainable alternative to conventional tin-based catalysts, thereby mitigating environmental impact and enhancing safety measures. The catalyst operates effectively under solvent-free conditions and does not require initiators, achieving a high polymer conversion rate of approximately 79%. The optimization of the reaction parameters was conducted using response surface methodology (RSM) employing a central composite design (CCD). The structural and chemical characterization of the catalyst as well as the resulting polymers was performed using proton nuclear magnetic resonance (1H NMR), Fourier-transform infrared spectroscopy (FTIR), and x-ray diffraction (XRD) analyses. Additionally, density functional theory (DFT) calculations elucidated a four-step coordination-insertion mechanism for the polymerization of cyclic lactones, with findings supported by Gibbs free energy, electrostatic potential, and non-covalent interactions. This study underscores the potential of zinc ascorbate as a reliable, nontoxic, and cost-effective catalyst, fulfilling the increasing demand for sustainable and efficient polymerization processes in commercial and biomedical applications.

10adensity function theory10aPolycaprolactone10aResponse surface methodology10aring-opening polymerization10azinc ascorbate1 aNaik, Sonali, S.1 aVedpathak, Shantanu1 aNair, Kiran, Sukumaran uhttps://library.ncl.res.in/content/optimization-and-mechanistic-insights-zinc-ascorbate-catalyst-ring-opening-polymerization