01603nas a2200265 4500008004100000022001400041245012300055210006900178260005700247300001200304490000700316520065300323653003100976653002301007653003601030653001701066653001701083653001401100100001701114700002401131700001801155700002201173700001801195856012401213 2010 eng d a1598-503200aTensile properties, cell adhesion, and drug release behavior of chitosan-silver-gelatin nanohybrid films and scaffolds0 aTensile properties cell adhesion and drug release behavior of ch a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGERcSEP a845-8520 v183 a

Drug-loaded nanohybrid films and porous scaffolds were prepared using chitosan, Ag nanoparticles and gelatin using a solution casting and freeze-drying method, respectively. Gelatin was used to incorporate the cell onto the surface of the scaffolds and the nanohybrid films. 1-[2-hydroxyethyl]-2-methyl-5-nitroimidazole) (Metronidazole (MTZ) was used as a model drug. The small percentage of Ag nanoparticles in the nanohybrid films and scaffolds produced significantly higher cell proliferation and levels of drug release. The tensile properties showed improvement in strength by Ag nanoparticles reinforcement at the expense of elongation.

10acarcinogenic metronidazole10acell proliferation10achitosan-Ag-gelatin nanohybrids10adrug release10anano-hybrids10ascaffolds1 aRana, V., K.1 aKushwaha, Omkar, S.1 aSingh, RajPal1 aMishra, Satyendra1 aHa, Chang-Sik uhttps://library.ncl.res.in/content/tensile-properties-cell-adhesion-and-drug-release-behavior-chitosan-silver-gelatin-002722nas a2200301 4500008004100000022001400041245012500055210006900180260008400249300001400333490000600347520162800353653002701981653004202008653001102050653001702061653002002078653000802098653002402106653001902130100002202149700002502171700002302196700002402219700002102243700002802264856012802292 2014 eng d a1178-201300aSynthesis of ciprofloxacin-conjugated poly(L-lactic acid) polymer for nanofiber fabrication and antibacterial evaluation0 aSynthesis of ciprofloxacinconjugated polyLlactic acid polymer fo aPO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALANDbDOVE MEDICAL PRESS LTDcMAR a1463-14770 v93 a

Ciprofloxacin was conjugated with polylactide (PLA) via the secondary amine group of the piperazine ring using PLA and 7-(4-(2-Chloroacetyl) piperazin-1-yl)-1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid. Zinc prolinate, a biocompatible catalyst was synthesized, characterized, and used in ring opening polymerization of L-lactide. Five different kinds of OH-terminated poly(L-lactide) (two-, three-, four-, six-arm, star-shaped) homopolymers were synthesized by ring opening polymerization of L-lactide in the presence of dodecanol, glycerol, pentaerythritol, dipentaerythritol as initiator and zinc prolinate as a catalyst. The structures of the polymers and conjugates were thoroughly characterized by means of gel permeation chromatography, matrix-assisted laser desorption/ionization-time of flight mass spectrometry, and nuclear magnetic resonance spectroscopy. PLA (molecular weight = 100,000) and ciprofloxacin conjugated PLA were used for fabrication of nonwoven nanofiber mat (diameter ranges; 150-400 nm) having pore size (62-102 nm) using electrospinning. The microbiological assessment shows that the release of ciprofloxacin possesses antimicrobial activity. The drug-release behavior of the mat was studied to reveal potential application as a drug delivery system. The result shows that the ciprofloxacin release rates of the PLA conjugate nonwoven nanofiber mat could be controlled by the drug loading content and the release medium. The development of a biodegradable ciprofloxacin system, based on nonwoven nanofiber mat, should be of great interest in drug delivery systems.

10aantibacterial activity10aciprofloxacin conjugated polylactides10aCP-PLA10adrug release10aelectrospinning10aMDR10anonwoven nanofibers10azinc prolinate1 aParwe, Sharad, P.1 aChaudhari, Priti, N.1 aMohite, Kavita, K.1 aSelukar, Balaji, S.1 aNande, Smita, S.1 aGarnaik, Baijayantimala uhttps://library.ncl.res.in/content/synthesis-ciprofloxacin-conjugated-polyl-lactic-acid-polymer-nanofiber-fabrication-and-002327nas a2200253 4500008004100000022001400041245008200055210006900137260000900206300001200215490000700227520152500234653001801759653001901777653001701796653001501813653002101828653001801849100002201867700002201889700002201911700002701933856011301960 2015 eng d a0928-493100aBioactive thermoresponsive polyblend nanofiber formulations for wound healing0 aBioactive thermoresponsive polyblend nanofiber formulations for  cMAR  a126-1370 v483 a

The rationale of this work is to develop new bioactive thermoresponsive polyblend nanofiber formulations for wound healing (topical). Various polymer compositions of thermoresponsive, poly(N-isopropylacrylamide), egg albumen and poly(epsilon-caprolactone) blend solutions with and without a drug [gatifloxacin hydrochloride, Gati] were prepared. Non-woven nanofibers of various compositions were fabricated using an electrospinning technique. The morphology of the nanofibers was analyzed by an environmental scanning electron microscope. The morphology was influenced by the concentration of polymer, drug, and polymer blend composition. Fourier transform infrared spectroscopy analysis showed the shift in bands due to hydrogen ion interactions between polymers and drug. Thermogram of PNIPAM/PCL/EA with Gati recorded a shift in lower critical solution temperature (LCST) and glass transition temperature (T-g) of PNIPAM. Similarly T-g and melting temperature (T-m) of PCL were shifted. X-ray diffraction patterns recorded a decrease in the crystalline state of PCL nanofibers and transformed crystalline drug to an amorphous state. In vitro release study of nanofibers with Gati showed initial rapid release up to 10 h, followed by slow and controlled release for 696 h (29 days). Nanofiber mats with Gati exhibited antibacterial properties to Staphylococcus aureus, supported suitable controlled drug release with in vitro cell viability and in vivo wound healing. (C) 2014 Elsevier B.V. All rights reserved.

10aAntibacterial10aCell viability10adrug release10ananofibers10athermoresponsive10awound Healing1 aPawar, Mahesh, D.1 aRathna, G., V. N.1 aAgrawal, Shubhang1 aKuchekar, Bhanudas, S. uhttps://library.ncl.res.in/content/bioactive-thermoresponsive-polyblend-nanofiber-formulations-wound-healing02461nas a2200253 4500008004100000022001400041245009800055210006900153260000800222300001100230490000700241520162000248653001901868653001701887653002001904653002701924653001501951653001701966100002901983700002102012700001702033700003402050856012302084 2022 eng d a1773-224700aBlend of neem oil based polyesteramide as magnetic nanofiber mat for efficient cancer therapy0 aBlend of neem oil based polyesteramide as magnetic nanofiber mat cSEP a1036290 v753 a

Stearic acid-coated magnetic nanoparticles (SMN) and FU (5-Fluorouracil) were immobilized in the blends of neem oil-based polyesteramide and fabricated as nanofiber mat (NM) for controlled release of FU under the influence of an external magnetic field for targeted drug delivery to treat cancer efficiently. Analyzed the surface morphology of the fibers using E-SEM, it was observed that the fibers were smooth with the diameter ranging from 250 to 450 nm. TEM studies showed the uniform distribution of SMN in the nanofibers. The physico-chemical properties of NM and raw materials were analyzed using FTIR, TGA, and XRD. The results suggested that the polymers were well blended. In-vitro FU release studies of the NMs recorded a significant difference in the cumulative percentage of FU release from SMN-NMs. The SMN-NMs released 95% of FU in 4 h, whereas, NMs released 83% of FU in 24 h. The cell viability assay for the NM was evaluated in the L929 mouse fibroblast cells, where >75% of cells were viable. The hemolysis assay for the developed SMN-NF showed <5% of hemolysis, which indicated the NMs were safe for application. The anti-cancer activity of FU loaded SMN-NF was analyzed in the MCF-7 cancer cell line, which recorded more than 50% cell death within 24 h. From SQUID analysis, we found that the 10% SMN were superparamagnetic in nature, the magnetization at 30 kOe was observed to be 4.3 emu/g. Based on the in vitro results, we concluded that the developed SMN-NMs are recommended for in vivo studies to understand their efficacy for the targeted drug delivery to treat cancer.

10a5-Fluorouracil10adrug release10aelectrospinning10aMagnetic nanoparticles10ananofibers10aStearic acid1 aPatel, Pratikshkumar, R.1 aSingam, Amarnath1 aDadwal, Arun1 aGundloori, Rathna, Venkata Na uhttps://library.ncl.res.in/content/blend-neem-oil-based-polyesteramide-magnetic-nanofiber-mat-efficient-cancer-therapy