01398nas a2200217   4500008004100000022001400041245005400055210005400109260008600163300001200249490000700261520069400268653002000962653001900982653001801001653001401019653001601033653002001049100002301069856008801092       2014                        eng d  a1860-539700aContinuous flow nitration in miniaturized devices0 aContinuous flow nitration in miniaturized devices  aTRAKEHNER STRASSE 7-9, FRANKFURT AM MAIN, 60487, GERMANYbBEILSTEIN-INSTITUTcFEB  a405-4240 v103 a<p>This review highlights the state of the art in the field of continuous flow nitration with miniaturized devices. Although nitration has been one of the oldest and most important unit reactions, the advent of miniaturized devices has paved the way for new opportunities to reconsider the conventional approach for exothermic and selectivity sensitive nitration reactions. Four different approaches to flow nitration with microreactors are presented herein and discussed in view of their advantages, limitations and applicability of the information towards scale-up. Selected recent patents that disclose scale-up methodologies for continuous flow nitration are also briefly reviewed.</p>10acontinuous flow10aflow chemistry10amicroreactors10anitration10anitric acid10aTubular reactor1 aKulkarni, Amol, A.  uhttps://library.ncl.res.in/content/continuous-flow-nitration-miniaturized-devices-0