01842nas a2200217   4500008004100000022001400041245008200055210006900137260006900206300001200275490000800287520110600295653001201401653002201413653001301435653001601448653000901464100002201473700001701495856011201512       2013                        eng d  a1385-894700aPhase, size and shape transformation by fungal biotransformation of bulk TiO20 aPhase size and shape transformation by fungal biotransformation   aPO BOX 564, 1001 LAUSANNE, SWITZERLANDbELSEVIER SCIENCE SAcAUG  a367-3710 v2303 a<p>Nanosynthesis is an ever expanding frontier in recent years in view of its implications to many future technologies covering diverse fields. Considerable progress has been made realizing high quality synthesis of elemental nanomaterials as well as compounds as chemical, biological and physical routes. The issue of technologically viable large scale synthesis still continues to be a challenge. Here we demonstrate a novel environmentally friendly top down approach to nanosynthesis which exploits the strength and peculiarities of fungus based bioleaching in extracting radicals from compounds and then providing them with a reactive as well as capping environment. Thus protein capped nanoparticles of TiO2 (5-28 nm, circular and brookite phase) are formed directly from micron size (150-250 nm, disc shape, anatase phase) powder by exposing them to a medium of fungus Humicola sp. at just 50 degrees C. The fungus Humicola sp. is not only useful for the synthesis of nanoparticles but also for the transformation of shape, phase and size of TiO2. (C) 2013 Elsevier B.V. All rights reserved.</p>10aAnatase10aBiotransformation10aBrookite10ahumicola sp10aTiO21 aKhan, Shadab, Ali1 aAhmad, Absar  uhttps://library.ncl.res.in/content/phase-size-and-shape-transformation-fungal-biotransformation-bulk-tio2-001826nas a2200229   4500008004100000022001400041245016600055210006900221260008600290300001200376490000600388520089900394653001901293653002001312653002101332653001601353653003701369100002201406700002001428700001701448856013101465       2014                        eng d  a2190-428600aExtracellular biosynthesis of gadolinium oxide (Gd2O3) nanoparticles, their biodistribution and bioconjugation with the chemically modified anticancer drug taxol0 aExtracellular biosynthesis of gadolinium oxide Gd2O3 nanoparticl  aTRAKEHNER STRASSE 7-9, FRANKFURT AM MAIN, 60487, GERMANYbBEILSTEIN-INSTITUTcMAR  a249-2570 v53 a<p>As a part of our programme to develop nanobioconjugates for the treatment of cancer, we first synthesized extracellular, protein-capped, highly stable and well-dispersed gadolinium oxide (Gd2O3) nanoparticles by using thermophilic fungus Humicola sp. The biodistribution of the nanoparticles in rats was checked by radiolabelling with Tc-99m. Finally, these nanoparticles were bioconjugated with the chemically modified anticancer drug taxol with the aim of characterizing the role of this bioconjugate in the treatment of cancer. The biosynthesized Gd2O3 nanoparticles were characterized by UV-vis spectroscopy, transmission electron microscopy (TEM), X-ray diffraction (XRD) and X-ray photoemission spectroscopy (XPS). The Gd2O3-taxol bioconjugate was confirmed by UV-vis spectroscopy and fluorescence microscopy and was purified by using high performance liquid chromatography (HPLC).</p>10abioconjugation10abiodistribution10agadolinium oxide10ahumicola sp10atransmission electron microscopy1 aKhan, Shadab, Ali1 aGambhir, Sanjay1 aAhmad, Absar  uhttps://library.ncl.res.in/content/extracellular-biosynthesis-gadolinium-oxide-gd2o3-nanoparticles-their-biodistribution-and-002331nas a2200301   4500008004100000022001400041245009800055210006900153260000900222300001000231490000700241520139200248653001701640653001701657653001701674653001401691653001601705653001701721100001501738700002601753700002101779700002701800700001901827700001701846700001801863700001701881856013101898       2022                        eng d  a1751-825300aAlpha Au2S nanoparticles: fungal-mediated synthesis, structural characterization and bioassay0 aAlpha Au2S nanoparticles fungalmediated synthesis structural cha  cJAN   a59-680 v153 aLuminescent nanoparticles synthesized via bio-based protocols that generate nanoparticles having different chemical compositions along with other functionalities (size and morphology) have received huge attention. We have focused our research on gold sulfide nanoparticles (Au2S NPs) and have biosynthesized these NPs using the fungus Humicola sp. The nanoparticles were characterized by Transmission Electron Microscopy, which showed spherical morphology of Au2S. UV-Visible-NIR spectrophotometry, luminescence spectrophotometry, Selected Area Electron Diffraction, Energy Dispersive Analysis of X-rays, and X-ray diffraction were performed. FTIR confirmed that the fungal metabolites including biomolecules secreted in the reaction medium are primarily responsible for nanoparticle synthesis and stabilization. The fungus reduced the precursor solution (HAuCl4 and Na2SO3) and at the same time capped them with secreted biomolecules. The anti-leishmanial activity of Au2S NPs was determined against L. donovani promastigote (Ag83 strain). Au2S NPs displayed less cytotoxicity towards both normal and cancer (Daudi, ZR-75-1) cell lines. Hemocompatibility was determined via hemolysis assays. This novel fungal-based system demonstrates an economical and environmentally benign process for biosynthesis of Au2S nanoparticles which may find application in bioimaging and labeling studies.10aBiosynthesis10aCytotoxicity10aGold sulfide10aHemolysis10ahumicola sp10apromastigote1 aSyed, Asad1 aSaedi, Marzouq, H. Al1 aBahkali, Ali, H.1 aElgorgan, Abdallah, M.1 aKharat, Mahesh1 aPai, Kalpana1 aPichtel, John1 aAhmad, Absar  uhttps://library.ncl.res.in/content/alpha-au2s-nanoparticles-fungal-mediated-synthesis-structural-characterization-and-bioassay