01997nas a2200253 4500008004100000022001400041245013800055210006900193260007300262300001200335490000800347520105500355653002101410653001301431653003301444653001101477653001401488653002401502653002201526100002101548700002401569700001801593856013201611 2007 eng d a0022-309300aStructural evolutions of hydrothermally prepared mesostructured MCM-48 silica using differently manufactured amorphous silica powders0 aStructural evolutions of hydrothermally prepared mesostructured  aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcFEB a194-1990 v3533 a

The hydrothermal synthesis of Si-MCM-48 mesoporous molecular sieves was carried out using a ternary SiO2:CTAOH:H2O System wherein differently manufactured amorphous silica powders such as fumed silica (FMDS), spray dried precipitated silica (SDPS) and flash dried precipitated silica (FDPS) were used as silica source materials. The changes in structural/textural properties were evaluated using powder XRD, N-2 adsorption-desorption and scanning electron microscopy techniques. Studies on the progressive development of MCM-48 mesophases revealed that, the reactivity of the silica source follow the trend: FMDS > SDPS > FDPS. MCM-48 synthesized using low cost FDPS has exhibited thicker pore walls but poorer orderness, while MCM-48 prepared from relatively expensive FMDS has thinner pore walls and more ordered structure. Moreover, the extent of contraction caused by calcinations, agglomerate size and structural stability were found to depend on the reactivity of the silica source used. (c) 2006 Elsevier B.V. All rights reserved.

10along-range order10amicelles10ascanning electron microscopy10asilica10asilicates10asol-gels (xerogels)10aX-ray diffraction1 aTaralkar, U., S.1 aJha, Ratnesh, Kumar1 aJoshi, P., N. uhttps://library.ncl.res.in/content/structural-evolutions-hydrothermally-prepared-mesostructured-mcm-48-silica-using-differently01765nas a2200229 4500008004100000022001400041245012100055210006900176260007700245300001400322490000800336520087100344653002301215653003201238653001301270653002301283653003301306100002001339700002101359700002601380856012901406 2014 eng d a1022-135200aEffect of the branching pattern of hydrophobic dendrons on the core structure of linear-dendritic copolymer micelles0 aEffect of the branching pattern of hydrophobic dendrons on the c aBOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcAUG a1456-14650 v2153 a

Hydrophobic dendrons based on different branching patterns, viz. 3,5-di- and 3,4,5-trisubstituted phenyl rings, consist of the same backbone but exhibit different sizes, shapes, and hydrophobic densities. These dendrons are attached to poly(ethylene glycol) and the core properties of the copolymer micelles are investigated in tetrahydrofuran (THF)/water mixtures by neutron scattering. Two polymers with intermediate hydrophobicity are studied further with variations in the solvent composition and the temperature. The aggregation numbers for 3,4,5-based dendron copolymers are lower, with more THF molecules of solvation compared with the 3,5-based dendron copolymer, the difference being greater at higher generations due to different molecular shapes. The micellar core size increases in small steps with dendron size so that dye encapsulation is tuned.

10adiblock copolymers10alinear-dendritic copolymers10amicelles10aneutron scattering10astructure-property relations1 aKalva, Nagendra1 aAswal, Vinod, K.1 aAmbade, Ashootosh, V. uhttps://library.ncl.res.in/content/effect-branching-pattern-hydrophobic-dendrons-core-structure-linear-dendritic-copolymer-002139nas a2200265 4500008004100000022001400041245015200055210006900207260000800276300001200284490000600296520121100302653002601513653002801539653001601567653001301583653002001596653001401616653001801630100001701648700003501665700002601700700001701726856013001743 2020 eng d a2637-610500aSelf-assembly of bispentadecylphenol substituted perylenediimide with PS-b-P4VP for structure-property insight into the core of core-shell micelles0 aSelfassembly of bispentadecylphenol substituted perylenediimide  cFEB a805-8160 v23 a

We report the use of a ditopic molecular probe bispentadecylphenol substituted perylenediimide (PBI-PDP) to examine the molecular level self-assembly of polystyrene-b-poly(4-vinylpyridine) (PS-b-P4VP) in tetrahydrofuran (THF). A series of complexes were prepared between PS-b-P4VP copolymers with varying lengths of the 4-vinylpyridine chain and PBI-PDP. Light scattering and NMR spectroscopic studies reveal that the self-assembled structures of the solid complexes are not fully disrupted when the complexes are dissolved in THF. NMR experimental parameters measured for the small probe molecule provide detailed insights into the structure of the assemblies in solution as well as the interaction between the small molecule and the block copolymer. Such insights can have important implications in manipulating the nanostructure of block copolymer micelles to suit various application requirements. The dynamics and distribution of the PBI-PDP molecules within the assemblies in solution show a dependence on the length of the P4VP block. Transmission electron microscopy was employed to study the evolution of morphologies in films prepared from the self-assembled structures in THF solutions.

10acore corona interface10aditopic molecular probe10aenvironment10amicelles10aperylenediimide10aPS-b-P4VP10aSelf-assembly1 aRoy, Moumita1 aRajamohanan, Pattuparambil, R.1 aRavindranathan, Sapna1 aAsha, S., K. uhttps://library.ncl.res.in/content/self-assembly-bispentadecylphenol-substituted-perylenediimide-ps-b-p4vp-structure-property02475nas a2200265 4500008004100000022001400041245013200055210006900187260000900256300001100265490000800276520158300284653002401867653000801891653001301899653001801912653001001930653002301940100002501963700002701988700002602015700001902041700002302060856012602083 2020 eng d a0378-517300aStimuli-responsive biodegradable polyurethane nano-constructs as a potential triggered drug delivery vehicle for cancer therapy0 aStimuliresponsive biodegradable polyurethane nanoconstructs as a cOCT  a1197810 v5883 a

Polyurethanes (PUs) constitute an essential class of stimuli-responsive and biodegradable material, which has significantly contributed to the advancement of polymers utilization in the biomedical field. The bio-erodible PUs construct an active corridor for facilitating drug into tumor cells, which has significantly impacted the progression of nano-micellar delivery systems. The self-assembled colloidal PUs pose distinctive features such as enhancing the solubility of hydrophobic chemotherapeutics, rapid cellular uptake, triggered erosion and drug release, bio-stimulus sensitivity, improvement in the targeting and proficiency of bioactive. Cationic PUs can easily be condensed with genetic material to form polyplexes and have shown excellent transfection efficiency for potential gene therapy against various cancers. Their modifiable chemistry offers a tool to impart the desired multifunctionality such as biocompatibility, sensitivity to pH, redox, temperature, enzyme, etc. and ligand conjugation for active targeting. These diverse exceptional properties make them excellent nano-carrier for a variety of bioactive, including chemotherapeutic drugs, DNA, RNA, and diagnostic moieties to the target tissue or cells. The PUs based nano-devices have certainly uncovered the path to achieve ideal systems for controlled personalized therapy. The literature discussed in this review shed light on the research innovations carried out in the last ten years for the development of multifunctional PUs for triggered delivery of bioactive to treat various cancers.

10aCancer nanomedicine10aGSH10amicelles10aPolyurathanes10aredox10aStimuli-responsive1 aGajbhiye, Kavita, R.1 aChaudhari, Bhushan, P.1 aPokharkar, Varsha, B.1 aPawar, Atmaram1 aGajbhiye, Virendra uhttps://library.ncl.res.in/content/stimuli-responsive-biodegradable-polyurethane-nano-constructs-potential-triggered-drug02241nas a2200241 4500008004100000022001400041245018700055210006900242260000800311300001100319490000800330520134800338653001801686653001301704653001801717653001801735653002001753653003101773100002201804700002601826700002201852856012501874 2024 eng d a0014-305700aPhoto and pH dual stimuli-responsive block copolymer micelles with defined incorporation of o-nitrobenzyl units in poly(ε-caprolactone) ε-caprolactone) block for controlled release0 aPhoto and pH dual stimuliresponsive block copolymer micelles wit cNOV a1135010 v2203 a

A series of dual stimuli-responsive block copolymers with varying content of photocleavable o-nitrobenzyl (ONB) ester group pendent in the hydrophobic poly(epsilon-caprolactone) block and pH-cleavable acetal linkage at the junction with hydrophilic poly(ethylene glycol) block is synthesized. The hydrophobic block is a random copolymer synthesized by ring-opening copolymerization of epsilon-caprolactone and ONB-substituted epsilon-caprolactone containing varying compositions of the two monomers. Kinetics of polymerization shows that ONBfunctionalized monomer has lower reactivity than that of the unsubstituted monomer. The series of block copolymers shows self-assembly into well-defined spherical micelles of average size of 150-200 nm in aqueous solution. Photocleavage of ONB groups is studied by NMR and UV-vis spectroscopy, and its extent is determined. The two stimuli viz. . UV light and pH are used individually as well as simultaneously to study the controlled release of the encapsulated drug Camptothecin and the synergistic effect of the two stimuli is demonstrated. The effect of varying content of ONB groups is observed on drug release profile. MTT assay showed non-cytotoxic nature of the polymer. Cell uptake and photoinduced release of doxorubicin (DOX) from the micelles in MDAMB-231 cells is demonstrated.

10adrug delivery10amicelles10aO-nitrobenzyl10apH-responsive10aPhotoresponsive10aPoly(epsilon-caprolactone)1 aAvhad, Shankarrao1 aChoudhari, Shakeb, N.1 aAmbade, Ashootosh uhttps://library.ncl.res.in/content/photo-and-ph-dual-stimuli-responsive-block-copolymer-micelles-defined-incorporation-o01982nas a2200241 4500008004100000022001400041245013900055210006900194260000900263300001200272490000700284520113000291653001101421653001901432653001301451653001801464653002901482100002401511700002901535700002101564700002601585856012901611 2024 eng d a1060-132500aVisible light and pH-responsive star copolymer and doxorubicin-polymer conjugate micelles for combination drug delivery and bioimaging0 aVisible light and pHresponsive star copolymer and doxorubicinpol cFEB  a105-1160 v613 a

Amphiphilic 3-arm star copolymer containing visible light-cleavable BODIPY group and pH-responsive imine bonds at the junction of hydrophilic poly(ethylene glycol) (PEG) and two poly(epsilon-caprolactone) (PCL) arms was synthesized by the combination of ring-opening polymerization (ROP) and click chemistry. The formation and stimuli-responsive disruption of micelles were analyzed using dynamic light scattering and transmission electron microscopy. Dual stimuli-responsive release of anticancer drugs Doxorubicin (Dox) and Camptothecin (CPT) from the micelles was studied. Micellar assemblies containing Dox conjugated to PEG-BODIPY through imine bonds were prepared and controlled release of Dox in response to visible light and pH was shown. CPT and Dox-loaded star copolymer micelles as well as CPT loaded Dox-conjugated micelles were used in cellular uptake studies on MDA-MB 231 cells, and the synergistic effect of the two stimuli on the release of the two drugs was demonstrated inside the cells. Micellar assemblies also showed excellent bioimaging properties in the cellular uptake studies. [GRAPHICS]

10aBODIPY10adrug conjugate10amicelles10apH-responsive10avisible light-responsive1 aBasutkar, Nitin, B.1 aSurapaneni, Sai, Geetika1 aAlam, Md., Shafi1 aAmbade, Ashootosh, V. uhttps://library.ncl.res.in/content/visible-light-and-ph-responsive-star-copolymer-and-doxorubicin-polymer-conjugate-micelles02255nas a2200277 4500008004100000022001400041245012900055210006900184260000800253300001100261490000800272520131600280653001801596653001501614653001801629653002601647653001701673653001301690653001801703653002101721100002601742700002901768700002401797700002601821856013001847 2026 eng d a0021-899500aRedox- and pH-responsive block copolymer nanocarriers with dual drug conjugation through dynamic covalent and hydrogen bonds0 aRedox and pHresponsive block copolymer nanocarriers with dual dr cMAR ae702050 v1433 a

Loading of multiple drugs in a nanocarrier with high entrapment efficiency is important for combination therapy in cancer treatment. Here, a block copolymer comprising hydrophobic poly(epsilon-caprolactone) block with a defined number of pendent propargyl groups, polyethylene glycol monomethyl ether as a hydrophilic block, and a redox-responsive disulfide group at the block junction is synthesized using click chemistry and ring-opening polymerization (ROP). Benzaldehyde and thymine groups are introduced in the side chains for selective attachment of anti-cancer drugs, doxorubicin (DOX) and methotrexate (MTX), via the formation of pH-responsive imine linkage and hydrogen bonds, respectively. The drug-conjugated block copolymers are assembled into spherical micelles of < 200 nm, and the preferential release of DOX and MTX in response to acidic pH and redox conditions is shown. At pH 5, DOX release was 59.5%, and MTX release was 40% compared to 13% and 12% at pH 7.4, whereas at pH 5 with 10 mM GSH, a DOX release of 81.5% was observed after 48 h. Cellular uptake of drug-conjugated micelles and their apoptosis compared to free DOX in the MDA-MB-231 breast cancer cells is demonstrated. Caveolae-mediated endocytosis was found to be the major pathway used by drug-loaded nanocarriers.

10abiodegradable10acopolymers10aDOX-conjugate10adrug delivery systems10amethotrexate10amicelles10apH-responsive10aredox-responsive1 aAvhad, Shankarrao, V.1 aSurapaneni, Sai, Geetika1 aPurohit, Poorvi, M.1 aAmbade, Ashootosh, V. uhttps://library.ncl.res.in/content/redox-and-ph-responsive-block-copolymer-nanocarriers-dual-drug-conjugation-through-dynamic