01858nas a2200277 4500008004100000022001400041245008900055210006900144260007300213300001400286490000800300520093600308653001301244653001701257653001801274653001901292100002001311700001501331700001801346700001801364700002101382700002201403700001701425700002501442856011301467 2008 eng d a0022-309300aSilicate nanoparticles by bioleaching of glass and modification of the glass surface0 aSilicate nanoparticles by bioleaching of glass and modification  aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcJUL a3433-34370 v3543 a

Bioleaching is examined as a low temperature (50 degrees C) soft chemical approach to nanosynthesis and surface processing. We demonstrate that fungus based bioleaching of borosilicate glass enables synthesis of nearly monodispersed ultrafine (similar to 5 +/- 0.5 nm) silicate nanoparticles. Using various techniques such as X-ray diffraction, X-ray photoelectron spectroscopy and FTIR we compare the constitution and composition of the nanoparticles with that of the parent glass, and establish the basic similarities between the two. The bioleaching process is shown to enhance the non-bridging oxygen component and correspondingly influence the Si-O-Si network. The root mean square roughness of glass surface is seen to increase from 1.27 nm for bare glass to 2.52 nm for 15 h fungal processed case, this increase being equivalent to that for glass annealed at 500 degrees C. (c) 2008 Elsevier B.V. All rights reserved.

10aBioglass10aBiomaterials10aborosilicates10anarroparticles1 aKulkarni, Sneha1 aSyed, Asad1 aSingh, Sanjay1 aGaikwad, Anil1 aPatil, Kashinath1 aVijayamohanan, K.1 aAhmad, Absar1 aOgale, Satishchandra uhttps://library.ncl.res.in/content/silicate-nanoparticles-bioleaching-glass-and-modification-glass-surface-001845nas a2200229 4500008004100000022001400041245009500055210006900150260007300219300001200292490000700304520098700311653001701298653002401315653005101339653001901390100002101409700002201430700002001452700002101472856012201493 2012 eng d a0167-577X00aGreen synthesis of TiO2 nanoparticles by using aqueous extract of Jatropha curcas L. latex0 aGreen synthesis of TiO2 nanoparticles by using aqueous extract o aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcMAY a196-1990 v753 a

Present study deals with a green synthesis of TiO2 nanoparticles by using 0.3% aqueous extract prepared from latex of Jatropha curcas L. TiO2 nanoparticles were characterized by X-ray diffraction (XRD), Selected Area Electron Diffraction (SAED), Transmission Electron Microscopy (TEM), Energy Dispersive Analysis of X-rays (EDAX) and Fourier Transform Infrared Spectroscopy (FTIR). Fourier Transform Infrared Spectroscopy (FTIR) were performed to find the role of curcain (enzyme), cyclic peptides namely curcacycline A (an octapeptide) and curcacycline B (a nonapeptide) as a possible reducing and capping agents, present in the latex of J. curcas L. The average size of TiO2 nanoparticles was found to be in the range of 25 to 100 nm. Our result shows that there are two broad categories of nanoparticles, first having diameter from 25 to 50 nm which are mostly spherical in shape and second having some larger and uneven shapes. (C) 2012 Elsevier B.V. All rights reserved.

10aBiomaterials10aElectron microscopy10aFourier Transform Infrared Spectroscopy (FTIR)10aNanostructures1 aHudlikar, Manish1 aJoglekar, Shriram1 aDhaygude, Mayur1 aKodam, Kisan, M. uhttps://library.ncl.res.in/content/green-synthesis-tio2-nanoparticles-using-aqueous-extract-jatropha-curcas-l-latex-001955nas a2200265 4500008004100000022001400041245010300055210006900158260007700227300001000304490000800314520100800322653001701330653001301347653002901360653001401389653001401403100002701417700001901444700002801463700002501491700002801516700002001544856012501564 2013 eng d a1022-136000aThermoresponsive and biodegradable dextran based microgels: synthesis and structural investigation0 aThermoresponsive and biodegradable dextran based microgels synth aBOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcJUL a27-340 v3293 a

Nanostructured objects, often ranging from hundreds of nanometers to few microns, support a number of functions directly linked to their structural features. They are, or they will be, protagonists in biomedical applications where miniaturized activities are required. These include the interface with living systems as tissues and cells, where targeted release of drug molecules occurs, or molecular imaging methods monitoring the drug trafficking in specific cell districts. The potentials of such devices, far to be fully understood, will be assessed only when a close correlation of their functions with their structure will be established. In this contribution we present a dextran based microdevice responsive to temperature and biodegradable. Both thermoresponsivity and biodegradability are of relevance for the potential use as drug carrier and controlled release device. The temperature behaviour, overall structure and internal architectures have been addressed with different methods.

10aBiomaterials10acolloids10adynamic light scattering10ahydrogels10ap(NiPAAm)1 aGhugare, Shivkumar, V.1 aChiessi, Ester1 aSakai, Victoria, Garcia1 aTelling, Mark, T. F.1 aWadgaonkar, Prakash, P.1 aParadossi, Gaio uhttps://library.ncl.res.in/content/thermoresponsive-and-biodegradable-dextran-based-microgels-synthesis-and-structural-001717nas a2200265 4500008004100000022001400041245008300055210006900138260007300207300001200280490000800292520084600300653001701146653001301163653001801176653001601194653001401210653000801224100001301232700002701245700002701272700002101299700001701320856011401337 2014 eng d a0167-577X00aBiological synthesis of cationic gold nanoparticles and binding of plasmid DNA0 aBiological synthesis of cationic gold nanoparticles and binding  aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcAUG a159-1610 v1293 a

Nanobiotechnology is the development of eco-friendly experimental processes for the synthesis of nanomaterials. The present work focuses on synthesis of cationic gold nanoparticles (C-GNPs) for biological applications, especially in gene and drug delivery studies. A biosynthesis methodology has been developed for the functionalization of gold nanoparticles to cationic nature. The synthesis of C-GNPs was done by using peanut leaf extract in the presence of cysteamine. The formed C-GNPs were characterized by using UV-visible spectroscopy (UV-vis), the particles sizes and shapes were confirmed by a Transmission electron microscope (TEM) and crystallinity of C-GNPs was characterized by diffraction. The binding of plasmid DNA on the C-GNPs was confirmed by agarose gel electrophoresis. (C) 2014 Elsevier B.V. All rights reserved.

10aBiomaterials10aCationic10aNanoparticles10aPlasmid DNA10asynthesis10aTEM1 aRaju, D.1 aVishwakarma, Rishi, K.1 aKhan, Bashir, Mohammad1 aMehta, Urmil, J.1 aAhmad, Absar uhttps://library.ncl.res.in/content/biological-synthesis-cationic-gold-nanoparticles-and-binding-plasmid-dna-002207nas a2200265 4500008004100000022001400041245010600055210006900161260000800230300001400238490000700252520132300259653002101582653001701603653002601620653001601646653002001662653001501682653001501697100002901712700001801741700001801759700003401777856013001811 2021 eng d a0032-388800aManipulating hydrophobicity of polyester nanofiber mats with egg albumin to enhance cell interactions0 aManipulating hydrophobicity of polyester nanofiber mats with egg cOCT a2496-25100 v613 aA hybrid of poly-l-lactic acid (PLA) and poly-epsilon-caprolactone (PCL) system was designed using hydrophilic generally regarded as safe (GRAS) protein, egg albumin (EA), and fabricated as nanofiber mats (NM) to facilitate improved cell interactions and functionality. Our studies include, preparation and analysis of physicochemical properties of NM. Surface morphology of NM was smooth with the diameter ranging from 250 to 400 nm. The contact angle of NM decreased from 80 to 45 degrees with the increase in EA concentration. The rate and extent of swelling was increased 3-folds with the addition of EA. Release studies of NM showed maximum amount of MTz was released with the increase in MTz concentration (>85%). The MTz interaction with EA and structure stability of EA was confirmed from fluorescence and circular dichroism studies. NM showed increase in inhibition of bacterial growth of Staphylococcus aureus and Escherichia coli with the increase in MTz concentration. Cell viability of the NM was >80% and also, the cell proliferation increased as EA content increased. NM hemolytic activity was less than 5% suggesting compatibility. Hence, results concluded that EA had regulated hydrophobicity, promoted cell interactions, and proliferation and therefore, NM is considered safe for tissue regeneration.10aBiocompatibility10aBiomaterials10adrug delivery systems10aegg albumin10aelectrospinning10ananofibers10apolyesters1 aPatel, Pratikshkumar, R.1 aPandey, Komal1 aKilli, Naresh1 aGundloori, Rathna, Venkata Na uhttps://library.ncl.res.in/content/manipulating-hydrophobicity-polyester-nanofiber-mats-egg-albumin-enhance-cell-interactions02281nas a2200253 4500008004100000022001400041245012000055210006900175260000800244300001100252490000800263520142300271653001701694653002801711653002601739653001001765653002801775100002001803700001901823700001801842700001801860700001701878856013201895 2023 eng d a0021-899500aControlled synthesis of thermosensitive tunable porous film of (pNIPAM)-b-(PCL) copolymer for sustain drug delivery0 aControlled synthesis of thermosensitive tunable porous film of p cMAY ae538540 v1403 a

There have been reports on different types of porous polymer films for various applications. The designing of such porous films with uniform properties is a challenging task. In this work, tunable porous thin films of poly(N-isopropylacrylamide) (pNIPAM) and polycaprolactone (PCL), that is, (pNIPAM)-b-(PCL) has been fabricated and its sustained drug delivery applications have been reported. First, the (pNIPAM)-b-(PCL) has been synthesized through the addition polymerization of pNIPAM and PCL. Then the synthesized (pNIPAM)-b(PCL) has been used to design porous thin film with varying temperatures without using any external template, below and above the lower critical solution temperatures (LCST) of pNIPAM. Pore size in (pNIPAM)-b-(PCL) films has been tuned by varying the temperature from similar to 10 to 40 degrees C. Then the developed thermosensitive porous film has been taken and seeded with the K562 (chronic myeloid leukemia blood cancer) and HepG2 (hepatocarcinoma) cells and the skin cancer cells (B16-F10) killing efficiency of anticancer drug (e.g., doxorubicin hydrochloride, DOX) loaded (pNIPAM)-b-(PCL) film has been studied. It is found that the DOX-loaded (pNIPAM)-b-(PCL) can efficiently kill the skin cancer cells. The porous polymer thin film reported in this work can be a versatile platform for the loading of drugs and it can be used for the various therapeutic applications.

10aBiomaterials10aBiomedical Applications10adrug delivery systems10afilms10ananostructured polymers1 aAmgoth, Chander1 aPatra, Sukanya1 aWasnik, Kirti1 aMaity, Pradip1 aPaik, Pradip uhttps://library.ncl.res.in/content/controlled-synthesis-thermosensitive-tunable-porous-film-pnipam-b-pcl-copolymer-sustain-drug02681nas a2200265 4500008004100000022001400041245012400055210006900179260000800248300001100256490000800267520176100275653001602036653001602052653002702068653001702095653002702112653002202139653003202161100002102193700002002214700002702234700002702261856012702288 2025 eng d a0001-868600aCritical advances in biofabrication and biomaterial strategies in tracheal tissue engineering: A comprehensive overview0 aCritical advances in biofabrication and biomaterial strategies i cNOV a1036040 v3453 a

The trachea is a vital respiratory organ that connects the larynx to the lungs and performs crucial functions. Various conditions can cause severe and often irreversible damage to individuals trachea of all age groups. Tracheal regeneration remains a major challenge in respiratory medicine, requiring a innovative solutions to address various underlying causes. Existing clinical interventions often have significant limitations and associated complications. Tissue engineering has potential, but its effectiveness has been limited due to challenges such as poor durability and insufficient revascularization. This review aims to provide a comprehensive exploration of the landscape of tracheal regeneration, shedding light on the path towards advancements in addressing extensive tracheal defects. It follows a structured approach, introducing various surgical procedures, along with their associated complications. Subsequently, it delves into the myriad biomaterials investigated in the realm of tracheal tissue engineering, emphasizing the significance of design considerations in scaffold fabrication. The review then navigates through various platforms utilized in tracheal tissue engineering and recent innovative approaches employed in this domain. Additionally, it provides insights into the clinical translation of tissueengineered trachea, highlighting recent advancements and challenges encountered in real-world applications. Finally, it discusses the significant challenges and offers a perspective outlook on the future of tracheal tissue engineering. Addressing current limitations and envisioning novel strategies, the review contributes to the ongoing dialogue and progression in this critical field of regenerative medicine.

10a3D printing10a4D printing10aAdditive manufacturing10aBiomaterials10aCell sheet engineering10aOrganoid printing10aTracheal tissue engineering1 aNaik, Sonali, S.1 aDutta, Naba, K.1 aNair, Kiran, Sukumaran1 aChoudhury, Namita, Roy uhttps://library.ncl.res.in/content/critical-advances-biofabrication-and-biomaterial-strategies-tracheal-tissue-engineering04782nas a2200265 4500008004100000245010400041210006900145260000800214300001200222490000700234520395300241653001604194653001704210653000804227653001204235653000804247653002204255653001804277100001804295700001804313700001704331700001604348700002004364856013204384 2025 eng d00aDLP 3D printing and characterization of PEEK-acrylate composite biomaterials for hip-joint implants0 aDLP 3D printing and characterization of PEEKacrylate composite b cJAN a172-1910 v273 a

Introduction. Hip joint replacement is considered the most complex and critically important orthopedic surgical procedure compared to knee and shoulder joint replacements. Over the past few decades, there has been significant advancement in hip joint replacement technology, and various biomaterials have been substantially improved. An increasing number of hip joint replacement surgeries are now successful, assisting individuals in regaining normal daily activity and work capacity comparable to their pre-fracture state. However, the need for revision surgery, specifically for implant replacement, is still observed in active patients several years following the initial operation. This underscores the need to develop durable biomaterials and customized hip joint implants to reduce implant wear and the risk of dislocation. This research study explores a novel PEEK-in-acrylate composite biomaterial with varied weight percentages of PEEK (0 %, 5 %, and 10 %) in an acrylate-based matrix. Tests were conducted to determine its properties, biocompatibility, and 3D printability. Based on the developed material, pins (in accordance with the ASTM standard) were fabricated using 3D printing for subsequent wear rate studies. The potential use of the developed composite materials for hip-joint applications was also thoroughly investigated. The purpose of this study is to develop and investigate a new PEEK in Acrylate composite biomaterial with varied weight percentages of PEEK (0 %, 5 %, and 10 %) in an acrylate-based matrix. The research includes an assessment of the material's properties, biocompatibility, and 3D printability. Using digital light processing (DLP) 3D printing technology at room temperature, pins (in accordance with the ASTM standard) were fabricated. An experimental study of dry sliding wear resistance was conducted on the resulting samples to determine the effect of PEEK weight fraction on the wear rate and frictional performance against an SS 316 steel disk. Scanning electron microscopy (SEM) and Energy-dispersive X-ray spectroscopy (EDS) were used to analyze the surface structure and element distribution within the material. The Methods of Investigation. Digital Light Processing (DLP) 3D Printing technique was used to 3D Print the ASTM pins and Acetabular liner with different weight fraction of PEEK in acrylate. Dry sliding wear tests were carried out using a pin-on-disk tribometer. During testing, the disk rotation speed and the normal load on the pin were varied. The studies were designed to determine the influence of input parameters on the wear rate. A total of nine experiments were conducted for each PEEK weight fraction, with a sliding distance of 4 km per experiment. The load ranged from 20 to 100 N, and the sliding speed varied from 450 to 750 rpm. Surface structure and element distribution were analyzed by Energy-dispersive X-ray spectroscopy (EDS) and Scanning electron microscopy (SEM). Result and Discussion. Current study demonstrates the advantages of varying the weight fraction of PEEK in Acrylate for DLP-fabricated biomaterials. Analysis of the SEM, EDS, and wear testing results indicated that the composite with 10 wt % PEEK in Acrylate exhibited superior microstructural integrity, elemental homogeneity, and significantly improved wear resistance. The 10 wt % PEEK in Acrylate composite, fabricated via DLP 3D printing, is suitable for biomedical implant and healthcare applications

10a3D printing10aBiomaterials10aFDM10aimplant10aPLA10aprint orientation10awear behavior1 aDama, Yogiraj1 aJogi, Bhagwan1 aPawade, Raju1 aPal, Shibam1 aGaikwad, Yogesh uhttps://library.ncl.res.in/content/dlp-3d-printing-and-characterization-peek-acrylate-composite-biomaterials-hip-joint-implants