01976nas a2200205   4500008004100000022001400041245014000055210006900195260000800264490000700272520116700279653003101446653002501477653002901502653003501531653001701566100002401583700003101607856013201638       2025                        eng d  a0021-891X00aAn effective alliance for successful coupling: electrochemical alcohol oxidation mediated conversion of indoles to bis(indolyl)methanes0 aeffective alliance for successful coupling electrochemical alcoh  cMAY0 v553 a<p>
	Electro-organic transformation of indoles to bis(indolyl)methanes (BIMs) has been successfully achieved by combining the electrochemical alcohol oxidation reaction (AOR) with indole coupling. The fact that it is the readily available alcohols and not the traditionally used aldehydes or ketones that provide the bridging -CH2- (methylene) for this transformation makes this path extremely attractive and valuable. The formation of aldehydes as reactive intermediates during the AOR has been dexterously utilized to achieve this transformation. Most gratifyingly, the transformation also can be carried out in water-alcohol mixtures and the yields and conversions are better than the most of the previously reported chemical catalytic transformations using specially designed metal complexes. Various substituted indoles were selectively converted to their corresponding BIMs in decent yields. This strategy could further be exploited for the synthesis of different natural products, including the much sought after deuterium substituted ones (as CD3OD is readily accessible), and other important biologically active alkaloids and drug molecules, etc.</p>
10aAlcohol oxidation reaction10aBis(indolyl)methanes10aDirect alcohol fuel cell10aElectroorganic transformations10aVibrindole A1 aBaravkar, Mayur, D.1 aPrasad, Bhagavatula, L. V.  uhttps://library.ncl.res.in/content/effective-alliance-successful-coupling-electrochemical-alcohol-oxidation-mediated-conversion