01720nas a2200265   4500008004100000022001400041245010200055210006900157260008600226300001200312490000800324520073800332653004201070653003001112653002101142653001501163653002401178653002801202653002701230653002001257100001501277700001601292700001701308856012901325       2005                        eng d  a0942-935200aTi-oxo radicals and product selectivity in olefin oxidations over titanosilicate molecular sieves0 aTioxo radicals and product selectivity in olefin oxidations over  aLEKTORAT MINT, POSTFACH 80 13 60, D-81613 MUNICH, GERMANYbOLDENBOURG VERLAGcJUL  a905-9200 v2193 a<p>The O-O bond of Ti-oxo species (Ti-peroxo, Ti-hydroperoxo or Ti-superoxo) generated on titanosilicate molecular sieves contacted with H2O2 cleaves either heterolytically or homolytically. While the former type of O-O cleavage (generating non-radical reactive oxygen intermediates) leads to selective epoxide products, the latter (generating reactive oxygen radical intermediates, O-2(-center dot) and HOOcenter dot) results in non-sclective, allylic oxidation products in cyclohexene oxidation. These radicals were detected using EPR spin trapping techniques 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) was used as the spin trap. Radical quenchers like hydroquinone suppressed their concentration and enhanced epoxide selectivity.</p>10acyclic voltammetry of titanosilicates10aEPR-spin trap experiments10aMolecular sieves10aoxidations10aproduct selectivity10areactive oxygen species10atitaniunz-oxo radicals10aTitanosilicates1 aShetti, VN1 aSrinivas, D1 aRatnasamy, P  uhttps://library.ncl.res.in/content/ti-oxo-radicals-and-product-selectivity-olefin-oxidations-over-titanosilicate-molecular-002489nas a2200277   4500008004100000022001400041245016500055210006900220260006700289300001000356490000800366520147900374653001401853653002101867653001501888653001501903653001901918653002801937100001701965700002101982700001602003700001702019700002102036700002602057856012802083       2015                        eng d  a1364-507200aPossible mechanism of antifungal phenazine-1-carboxamide from pseudomonas sp against dimorphic fungi Benjaminiella poitrasii and human pathogen Candida albicans0 aPossible mechanism of antifungal phenazine1carboxamide from pseu  a111 RIVER ST, HOBOKEN 07030-5774, NJ USAbWILEY-BLACKWELLcJAN  a39-480 v1183 a<p>AimInvestigation of antifungal mechanism of phenazine 1-carboxamide (PC) produced by a Pseudomonas strain MCC2142. Methods and ResultsAn antifungal metabolite produced by a Pseudomonas was purified and identified as PC. Human pathogenic fungi such as Candida albicans, Candidaglabrata, Cryptococcus neoformans, Fusarium oxysporum, Aspergillus fumigatus and Aspergillus niger were found to be inhibited by PC (MIC90 32-64gml(-1)). Addition of PC (20gml(-1)) during yeast (Y)-hypha (H) transitions inhibited germ tube formation by &gt;90% and &gt;99% in C.albicans National Collection of Industrial Microorganisms (NCIM) 3471 and nonpathogenic model Benjaminiella poitrasii, respectively. After exposure to PC (20gml(-1)), 75-80% yeast cells of B.poitrasii and C.albicans NCIM 3471 showed rhodamine 123 fluorescence indicating high intracellular reactive oxygen species (ROS) production. ROS further led to hyperpolarization of mitochondrial membrane, subsequently induction of apoptosis as evident by externalization of phosphatidylserine, DNA fragmentation, chromatin condensation and finally death in B.poitrasii. In C.albicans NCIM 3471, PC (20gml(-1)) induced apoptosis. ConclusionsThe antifungal effect of PC in B.poitrasii and C.albicans may be due to ROS-mediated apoptotic death. Significance and Impact of the StudyInhibition of Y-H transition of B.poitrasii and C.albicans by PC indicates that it may prove useful in the control of dimorphic human pathogens.</p>10aApoptosis10aCandida albicans10adimorphism10aphenazines10aPseudomonas sp10areactive oxygen species1 aTupe, S., G.1 aKulkarni, R., R.1 aShirazi, F.1 aSant, D., G.1 aJoshi, Swati, P.1 aDeshpande, Mukund, V.  uhttps://library.ncl.res.in/content/possible-mechanism-antifungal-phenazine-1-carboxamide-pseudomonas-sp-against-dimorphic-001879nas a2200217   4500008004100000022001400041245011700055210006900172260007300241300001000314490000800324520104600332653002101378653002801399653001701427653002201444653002301466100002101489700002101510856013001531       2016                        eng d  a0926-860X00aSpectroscopy and catalytic activity study of gold supported on barium titanate nanotubes for styrene epoxidation0 aSpectroscopy and catalytic activity study of gold supported on b  aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcAUG  a61-720 v5233 a<p>Gold (0.5-5 wt.%) supported on barium titanate nanotubes (Au/BaTNT) were prepared, characterized and for the first time, investigated as catalysts for selective oxidation of styrene with oxygen (O-2 or H-2 + O-2) and peroxides (H2O2 or TBHP). Conversion of styrene enhanced when H-2 was co-added to O-2 in the reactions. Au/BaTNT activated O-2 and H-2 and produced H2O2 in situ for use in oxidations. Peroxides were found better oxidants than O-2. At optimized conditions, styrene oxide selectivity of 80.1 wt.% at styrene conversion of 60.5 wt.% was achieved over Au(1 wt.%)/BaTNT using TBHP. Au particles (5.0-7.4 nm) were dispersed and decorated on the walls of BaTNT. They exhibited superior performance to the known Au catalysts in styrene oxidation. Reactive oxygen species formed during oxidation reactions were followed with in situ spectral characterizations (diffuse reflectance UV-vis and FT -Raman). Au/BaTNT was reusable in four recycles with little loss in catalytic activity. (C) 2016 Elsevier B.V. All rights reserved.</p>10aAu Nanoparticles10areactive oxygen species10aspectroscopy10aStyrene Oxidation10aTitanate nanotubes1 aNepak, Devadutta1 aSrinivas, Darbha  uhttps://library.ncl.res.in/content/spectroscopy-and-catalytic-activity-study-gold-supported-barium-titanate-nanotubes-styrene01836nas a2200289   4500008004100000022001300041245012500054210006900179260000900248300001200257490000600269520088800275653002901163653001301192653001701205653002801222653002501250653001701275100001601292700001301308700001901321700002201340700001801362700001701380700002101397856012801418       2018                        eng d  a2053159100aSurface colonized silver nano particles over chitosan poly-electrolyte micro-spheres and their multi-functional behavior0 aSurface colonized silver nano particles over chitosan polyelectr  cFEB   a 0250320 v53 ahitosan/tripolyphosphate polyelectrolyte (TPP) microspheres, decorated and surface functionalized with silver nanoparticles (NPs) of average diameter of 15 nm, were synthesized following a simple two-step procedure. These Ag NP-functionalized polyelectrolyte microspheres (Ag-CSPMs) are found to be biocompatible and enhancing the reactive oxygen species in curcumin with excellent anti-bacterial activity for selected Gram-positive and negative bacterial strains, making them much attractive relative to bare surface counterparts; the well-stabilized silver NPs do not form any agglomerations on the surface of the chitosan microspheres. They also show excellent cytotoxic behavior towards MCF7 cell lines, showing a half-maximal inhibitory concentration (IC50) of 32 μg ml-1. Therefore, Ag-CSPMs exhibit multi-functional ability having potential towards theranostics applications.10aantibacterial properties10aChitosan10aCytotoxicity10areactive oxygen species10asilver nanoparticles10atheranostics1 aPrakash, B.1 aAsha, S.1 aAnanth, A., N.1 aVanithakumari, G.1 aOkram, G., S.1 aJose, S., P.1 aRajan, M., A. J.  uhttps://library.ncl.res.in/content/surface-colonized-silver-nano-particles-over-chitosan-poly-electrolyte-micro-spheres-and02234nas a2200277   4500008004100000022001400041245011600055210006900171260000800240300001200248490000700260520132600267653001601593653002201609653001401631653001401645653002201659653001201681653001001693653002801703100002801731700001601759700002701775700002501802856012901827       2020                        eng d  a0929-866500aAnticancer activity of lectins from bauhinia purpurea and wisteria floribunda on breast cancer MCF-7 cell lines0 aAnticancer activity of lectins from bauhinia purpurea and wister  cJAN  a870-8770 v273 a<p>Background: Individual and collaborative efforts are being made worldwide in search of effective chemical or natural drugs with less severe side-effects for treatment of cancer. Due to the specificity and selectivity properties of lectins for saccharides, several plant lectins are known to induce cytotoxicity into tumor cells. Objective: To study the antiproliferative activity of two N-acetyl galactosamine specific plant lectins from seeds of Bauhinia purpurea and Wisteria floribunda against MCF-7 Breast cancer cell lines. Methods: MTT, lactate dehydrogenase (LDH) leakage, reactive oxygen species (ROS), and caspase-3 assays and flow cytometry for cell cycle analysis were performed. Results: The agglutinins BPL and WFL; 446 mu gml(-1) (2.2 mu M) and 329 mu gml(-1) (2.8 mu M), respectively caused remarkable concentration-dependent antiproliferative effect on MCF-7. The effect was seen to be a consequence of binding of the lectin to the cell surface and triggering S and G2 phase arrest. Apoptosis induced was found to be associated with LDH leakage, cell cycle arrest and ROS generation. The apoptotic signal was observed to be amplified by activation of caspase-3 resulting in cell death. Conclusion: The study provides a base for detailed investigation and further use of lectins in cancer studies.</p>
10aanti-cancer10aantiproliferative10aApoptosis10acaspase-310acell cycle arrest10aLectins10aMCF-710areactive oxygen species1 aAgrawal, Sanskruthi, B.1 aGupta, Neha1 aBhagyawant, Sameer, S.1 aGaikwad, Sushama, M.  uhttps://library.ncl.res.in/content/anticancer-activity-lectins-bauhinia-purpurea-and-wisteria-floribunda-breast-cancer-mcf-702778nas a2200325   4500008004100000245012400041210006900165260000800234300000700242490000700249520169500256653002401951653002001975653002701995653002302022653001702045653001402062653002002076653002802096100002202124700002202146700002202168700002302190700002602213700001902239700002202258700001802280700002202298856013202320       2023                        eng d00aAntiviral and ROS scavenging potential of Carica papaya Linn and Psidium guajava leaves extract against HIV-1 infection0 aAntiviral and ROS scavenging potential of Carica papaya Linn and  cMAR  a820 v233 a<p>
	Antiretroviral therapy is the only treatment option for HIV-infected patients; however, it has certain drawbacks in terms of developing multiple toxic side effects. Thus, there is a continuous need to explore safe and efficacious anti-retroviral agents. Carica papaya Linn and Psidium guajava are known for their various biological activities. In this study, we characterized the bioactive fractions of methanolic leaves extract from both plants using the High-resolution electrospray ionization mass spectrometry (HR-ESI-MS) technique, followed by the investigation of their potential as anti-HIV-1 and antioxidant agents through in vitro mechanistic assays. The anti-HIV-1 activity was examined in TZM-bl cells through luciferase gene assay against two different clades of HIV-1 strains, whereas the intracellular ROS generation was analyzed by Fluorescence-Activated Cell Sorting. Additionally, the mechanisms of action of these phyto-extracts were determined through the Time-of-addition assay. The characterization of Carica papaya Linn and Psidium guajava leaves extract through HR-ESI-MS fragmentation showed high enrichment of various alkaloids, glycosides, lipids, phenolic compounds, terpenes, and fatty acids like bioactive constituents. Both the phyto-extracts were found to be less toxic and exhibited potent antiviral activity against HIV-1 strains. Furthermore, the phyto-extracts also showed a decreased intracellular ROS in HIV-1 infected cells due to their high antioxidant potential. Overall, our study suggests the anti-HIV-1 potential of Carica papaya Linn and Psidium guajava leaves extract due to the synergistic action of multiple bioactive constituents.</p>
10aanti-HIV-1 activity10aAnti-retroviral10aBioactive constituents10aCarica papaya Linn10aCytotoxicity10aHR-ESI-MS10aPsidium guajava10areactive oxygen species1 aJadaun, Pratiksha1 aShah, Prachibahen1 aHarshithkumar, R.1 aSaid, Madhukar, S.1 aBhoite, Shubhangi, P.1 aBokuri, Sowmya1 aRavindran, Selvan1 aMishra, Neetu1 aMukherjee, Anupam  uhttps://library.ncl.res.in/content/antiviral-and-ros-scavenging-potential-carica-papaya-linn-and-psidium-guajava-leaves-extract