01672nas a2200265   4500008004100000022001400041245007400055210006900129260000900198300000700207490000800214520085900222653002801081653002301109653001601132653002401148653001101172653002001183653001801203100001801221700002301239700002101262700002101283856010201304       2024                        eng d  a0974-362600aEfficient one-pot process for synthesis of antiviral drug Ganciclovir0 aEfficient onepot process for synthesis of antiviral drug Gancicl  cSEP   a710 v1363 a<p>
	A regioselective novel one-pot synthesis of heterocyclic purine derivative antiviral agent Ganciclovir in which initially guanine is treated with acetic anhydride in the presence of iodine (5%) to get diacetyl guanine intermediate, which undergoes in situ N-alkylation with AMDP in presence of catalytic acidic Amberlite IR-120 to get N-alkylated intermediate and finally deacetylation to get pure regioselective Ganciclovir, which is commercially viable and eco-friendly.Graphical abstractWe developed one-pot synthesis of antiviral drug Ganciclovir. Initially, Guanine is treated with acetic anhydride and iodine to yield diacetyl guanine 3. This intermediate then reacted with AMDP in the presence of acidic Amberlite IR-120 to obtain compound 5. Finally, deacetylation yields Ganciclovir 1, a commercially viable and eco-friendly process.</p>
10aAcidic Amberlite IR-12010aacyclic nucleoside10aanti-herpes10acommercially viable10aiodine10aone-pot process10aregiospecific1 aSudrik, Vilas1 aKarpe, Dnyaneshwar1 aJadhav, Vrushali1 aLawande, Shamrao  uhttps://library.ncl.res.in/content/efficient-one-pot-process-synthesis-antiviral-drug-ganciclovir02285nas a2200217   4500008004100000245009800041210006900139260000800208300001200216490000600228520156200234653002301796653001101819653001801830653001201848653001701860100001501877700001901892700003101911856012501942       2026                        eng d00aSelf-powered photodetection in AgBiS2 nanocrystals synthesized from AgBi-mixed-metal thiolate0 aSelfpowered photodetection in AgBiS2 nanocrystals synthesized fr  cJAN  a448-4560 v93 a<p>
	AgBiS2 has emerged as a promising optoelectronic material owing to its high absorption coefficient, environmentally friendly and abundant components, offering a sustainable alternative to lead- and cadmium-based chalcogenides. Realizing the full potential of AgBiS2 devices, however, requires scalable synthesis routes that include development of suitable precursors and minimize the use of harsh solvents, elevated temperatures, inert environments, etc. Here, we present a facile, solvent-free synthesis of phase pure AgBiS2 nanocrystals (NCs) at room temperature and under ambient conditions, enabled by the AgBi mixed-metal thiolate (AgBi-MMT) precursor complex. The initial choice of metal salts determines the nature of the metal thiolate intermediate complex, which subsequently influences the quality of the resulting AgBiS2 NCs. As a single-source precursor of the metals, AgBi-MMT enables controlled release of Ag+ and Bi3+ ions, yielding phase-pure AgBiS2 NCs. Furthermore, the MMT that is derived from AgI and BiI3 precursors promotes in situ surface passivation of the AgBiS2 NCs by iodide ions by trapping molecular I2 within its matrix. Under illumination, these iodide ions undergo reversible migration, generating a built-in potential and enabling self-powered photodetection in devices prepared from the as-synthesized NCs. This work expands the synthesis methodology of AgBiS2, highlighting the importance of metal thiolates as precursors in nanomaterial syntheses, and influence of iodine species in photo-operational devices.</p>
10abuilt-in potential10aiodine10aion migration10alayered10aquantum dots1 aDas, Mouli1 aSwathi, S., P.1 aPrasad, Bhagavatula, L. V.  uhttps://library.ncl.res.in/content/self-powered-photodetection-agbis2-nanocrystals-synthesized-agbi-mixed-metal-thiolate