01477nas a2200217   4500008004100000022001400041245010200055210006900157260000800226300001500234490000700249520075700256653001501013653001901028653001301047653001601060653001401076100002401090700002001114856012501134       2022                        eng d  a1861-472800aManganese-catalyzed C(sp(2))-H alkylation of indolines and arenes with unactivated alkyl bromides0 aManganesecatalyzed Csp2H alkylation of indolines and arenes with  cMAY  ae2022001030 v173 a<p>
	Selective C(sp(2))-H bond alkylation of indoline, carbazole and (2-pyridinyl)arenes with unactivated alkyl bromides is achieved using MnBr2 catalyst in the absence of an external ligand. The alkylation uses a simple LiHMDS base and avoids the necessity of Grignard reagent, unlike other Mn-catalyzed C-H functionalization. This reaction proceeded either through a five- or a less-favored six-membered metallacycle, and tolerated diverse functionalities, including alkenyl, alkynyl, silyl, aryl ether, pyrrolyl, indolyl, carbazolyl and alkyl bearing fatty alcohol and polycyclic-steroid moieties. Alkylation follows a single electron transfer (SET) pathway involving 1e oxidative addition of alkyl bromide and a rate-limiting C-H metalation.</p>
10aAlkylation10aC-H activation10aindoline10aligand-free10amanganese1 aVerma, Suryadev, K.1 aPunji, Benudhar  uhttps://library.ncl.res.in/content/manganese-catalyzed-csp2-h-alkylation-indolines-and-arenes-unactivated-alkyl-bromides02394nas a2200241   4500008004100000022001400041245012500055210006900180260000800249490000900257520156100266653002801827653002101855653001601876653001501892653002001907100001701927700002101944700001901965700002501984700001902009856012402028       2024                        eng d  a0022-328X00aCuNPs@Al2O3-cellulose composite for the ligand-free Suzuki cross-coupling reactions in batch and continuous flow process0 aCuNPsAl2O3cellulose composite for the ligandfree Suzuki crosscou  cJAN0 v10043 a<p>In the present work, we synthesized recyclable CuNPs@Al2O3-CELL composite from an inexpensive and commercially available synthetic reagent by a simple method. The catalyst was characterized by various techniques such as TGA (Thermogravimetric analysis), SEM (Scanning electron microscope), TEM (Transmission electron microscopy), XPS (X-ray photoelectron spectroscopy), EDS (Energy dispersive spectroscopy), and AAS (Atomic Absorption Spectroscopy). The composite was applied for the Suzuki coupling reactions in the batch and flow process. The aryl halides were easily coupled with arylboronic acids in 95 % ethanol at 78 C. We systematically investigated the role of reaction temperature, solvent, and catalyst loading, on the transient and steady-state behavior of the flow reactor through an automated flow chemistry platform. The CuNPs@Al2O3CELL catalytic particles demonstrate minimal deactivation and leaching over a continuous Suzuki coupling reaction at a 20 min nominal residence time at 100 C. Moreover, the catalyst can be recovered by simple filtration and reused at least five times with a moderate decrease in product yield. The excellent activity and stability of the catalyst have been attributed to the strong chelation of the Cu species with hydroxyl functional groups of the Al2O3-CELL composite. The catalytic system was highly efficient in Suzuki coupling of various aryl bromides with different aryl boronic acids, yielding good to excellent product yields (80-96 %) with a TON of 15.914-19.066 and TOF of 2.649-9.533 h(-1).</p>
10aContinuous flow process10aCuNPs@Al2O3-CELL10aligand-free10arecyclable10aSuzuki coupling1 aPatil, Seema1 aRajmane, Archana1 aJadhav, Sanjay1 aRode, Chandrashekhar1 aKumbhar, Arjun  uhttps://library.ncl.res.in/content/cunpsal2o3-cellulose-composite-ligand-free-suzuki-cross-coupling-reactions-batch-and