00983nas a2200241 4500008004100000022001400041245004900055210004900104260008600153300001400239490000700253520022800260653001600488653001400504653001200518653002100530653002000551100002400571700002200595700001800617700002300635856008300658 2007 eng d a0039-791100aShort and efficient synthesis of rubrolide E0 aShort and efficient synthesis of rubrolide E a325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USAbTAYLOR & FRANCIS INCcDEC a4253-42630 v373 a

Short and efficient synthesis of rubrolide E from commercially available 4-methoxyacetophenone, employing ring-closing metathesis, Knoevenagel condensation, and Reformatsky reactions, are the key steps are described.

10aantibiotics10aantitumor10aEpoxide10aNatural products10aTotal synthesis1 aChavan, Subhash, P.1 aPathak, Ashok, B.1 aPandey, Ankur1 aKalkote, Uttam, R. uhttps://library.ncl.res.in/content/short-and-efficient-synthesis-rubrolide-e-001852nas a2200241 4500008004100000022001400041245012100055210006900176260016500245300001200410490000700422520084600429653001601275653003601291653002001327653001501347653001001362100002401372700002501396700003701421700002501458856012701483 2011 eng d a0388-135000aComparative and chemical proteomic approaches reveal gatifloxacin deregulates enzymes involved in glucose metabolism0 aComparative and chemical proteomic approaches reveal gatifloxaci aINTERNATIONAL MEDICAL INFORMATION CENTER, SHINANOMACHI RENGAKAN, 35 SHINANO-MACHI, SHINJUKU-KU, TOKYO, 160-0016, JAPANbJAPANESE SOC TOXICOLOGICAL SCIENCEScDEC a787-7960 v363 a

Gatifloxacin has been associated with increased risks of hypoglycemic and hyperglycemic side effects. In order to understand the molecular mechanism of gatifloxacin induced deregulation of glucose metabolism, a Combination of comparative and chemical proteomic approaches were employed using yeast as a model system. Differential protein expression studies using two dimensional electrophoresis and mass spectrometry reveal that gatifloxacin deregulates the expression of key enzymes involved in glucose metabolism. Furthermore, affinity chromatography and LC-MSE analysis led to identification of enolase, as one of the key gatifloxacin binding proteins. Fluorescence spectrometric studies confirmed that the gatifloxacin indeed binds to enolase. Role of enolase in regulation of gatifloxacin induced dysglycemic effect is discussed.

10aantibiotics10aDifferential protein expression10aFluoroquinolone10aGlycolysis10aYeast1 aSuresh, Kesavan, K.1 aBhosale, Santosh, D.1 aThulasiram, Hirekodathakallu, V.1 aKulkarni, Mahesh, J. uhttps://library.ncl.res.in/content/comparative-and-chemical-proteomic-approaches-reveal-gatifloxacin-deregulates-enzymes-001931nas a2200325 4500008004100000022001400041245006800055210006700123260007700190300001400267490000700281520089600288653001601184653001301200653002101213653002101234653002001255100001701275700001701292700001801309700001801327700002401345700002601369700002601395700001701421700002301438700001801461700002401479856010201503 2015 eng d a0947-653900aTotal and semi-syntheses of antimicrobial thuggacin derivatives0 aTotal and semisyntheses of antimicrobial thuggacin derivatives aBOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcMAR a4272-42840 v213 a

The total and semi-synthesis of 13 new macrolactones derived from thuggacin, which is a secondary metabolite from the myxobacterium Sorangium cellulosum, are reported. The thuggacins have attracted much attention due to their strong antibacterial activity, particularly towards Mycobacterium tuberculosis. This study focuses on 1) thuggacin derivatives that cannot equilibrate by transacylation between the three natural thuggacins A-C, 2) the roles of the thiazole ring, and 3) the hexyl side chain at C2. Semi-synthetic O-methylation at C17 suppressed the transacylations without a substantial loss of antibacterial activity. Exchanging the C17-C25 side chain for simplified hydrophobic chains led to complete loss of antibacterial activity. Exchange of the thiazole by an oxazole ring or removal of the hexyl side chain at C2 had no substantial effect on the biological properties.

10aantibiotics10alactones10aNatural products10asynthesis design10aTotal synthesis1 aFranke, Jana1 aBock, Martin1 aDehn, Richard1 aFohrer, Joerg1 aMhaske, Santosh, B.1 aMigliorini, Antonella1 aKanakis, Argyrios, A.1 aJansen, Rolf1 aHerrmann, Jennifer1 aMueller, Rolf1 aKirschning, Andreas uhttps://library.ncl.res.in/content/total-and-semi-syntheses-antimicrobial-thuggacin-derivatives-001571nas a2200337 4500008004100000022001400041245013500055210006900190260000800259490000700267520044100274653001200715653001600727653001700743653002000760653001600780653001400796653004100810653001700851653001600868653002500884653001100909653002400920653003700944653002900981100002801010700002601038700002601064700002401090856011901114 2017 eng d a0039-788100aPhenol oxidative dearomatization of modified nucleoside templates: a simple access to the c7-spiroannulated octosyl acid framework0 aPhenol oxidative dearomatization of modified nucleoside template cSEP0 v493 a

Phenol oxidative dearomatization and cyclization has been executed successfully on nucleoside templates to synthesize C7-spiroannulated perhydrofuropyran nucleosides and C6-spiroannulated perhydrofurofuran nucleosides as novel analogues of octosyl acid and related peptidyl nucleosides.

10aAnalogs10aantibiotics10aBiosynthesis10aChitin synthase10aDerivatives10aEzomycins10aGlucose Diacetonide Natural-products10aGriseofulvin10aMalayamycin10aModified nucleosides10aMoiety10aPeptidyl Glycosides10aPhenol Oxidative Dearomatization10aVorbruggen Glycosylation1 aMullapudi, Venkannababu1 aBhogade, Ravindra, B.1 aDeshpande, Mukund, V.1 aRamana, Chepuri, V. uhttps://library.ncl.res.in/content/phenol-oxidative-dearomatization-modified-nucleoside-templates-simple-access-c7