00760nas a2200181   4500008004100000022001400041245011000055210006900165260009500234300001200329490000800341100002100349700001400370700001800384700002400402700002000426856013200446       2005                        eng d  a0003-269700aQuantitative method for normalization of transfection efficiency using enhanced green fluorescent protein0 aQuantitative method for normalization of transfection efficiency  a525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USAbACADEMIC PRESS INC ELSEVIER SCIENCEcJUL  a341-3440 v3421 aDandekar, D., H.1 aKumar, M.1 aLadha, J., S.1 aGanesh, Krishna, N.1 aMitra, Debashis  uhttps://library.ncl.res.in/content/quantitative-method-normalization-transfection-efficiency-using-enhanced-green-fluorescent-001264nas a2200193   4500008004100000022001400041245011400055210006900169260007100238300001400309490000700323520051100330100002400841700001700865700001700882700002000899700002100919856013000940       2006                        eng d  a0022-262300aAmino functionalized novel cholic acid derivatives induce HIV-1 replication and syncytia formation in T cells0 aAmino functionalized novel cholic acid derivatives induce HIV1 r  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcAPR  a2652-26550 v493 a<p>Synthesis of C-11 azido/amino functionalized cholic acid derivatives has been achieved in excellent yields. Contrary to the previous prediction of analogous compounds to be HIV-1 protease inhibitors, in the present study these novel cholic acid derivatives induced host cell fusion during the progress of HIV-1 infection and produced multinucleated giant cells. This is the first report of syncytia induction and enhancement of viral replication in HIV-1 infected T cells by cholic acid derivatives.</p>1 aSalunke, Deepak, B.1 aRavi, D., S.1 aPore, V., S.1 aMitra, Debashis1 aHazra, Braja, G.  uhttps://library.ncl.res.in/content/amino-functionalized-novel-cholic-acid-derivatives-induce-hiv-1-replication-and-syncytia-002025nas a2200193   4500008004100000245018300041210006900224260000800293300001200301490000800313520126100321100001801582700001701600700002001617700002301637700001901660700002001679856013201699       2018                        eng d00aDesign, synthesis, docking studies and biological screening of 2-thiazolyl substituted-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazines as potent HIV-1 reverse transcriptase inhibitors0 aDesign synthesis docking studies and biological screening of 2th  cSEP  a310-3190 v1573 a1,3-oxazine nucleus and thiazolyl group features prominently in many biologically important natural products as well as bioactive molecules. A series of novel 2-thiazolyl substituted-2,3-dihydro-1H-naphtho [1,2-e][1,3]oxazine derivatives were designed and synthesized based on their structure-activity relationships (SARs) from 2-naphthol, substituted thiazolyl amines and formalin through ring closure by one-pot three component reaction. These derivatives were first evaluated for their inhibitory effect on HIV-1 Reverse Transcriptase (RT) enzyme activity. Out of 14 compounds, 4 showed potent inhibition of HIV-1 RT activity at significantly low concentration. Docking studies of these molecules revealed their high affinity binding to several amino acids of HIV-1 RT which are less sensitive to point mutations. Furthermore, anti-HIV activity of these molecules was analysed in a CD4(+) T cell-line, which indicates that Therapeutic Index (TI) of some of these compounds is better than Zidovudine and Efavirenz, known HIV-1 RT inhibitors. Taken together, our studies report for the first time some novel naphthoxazine derivatives with significant TI, which is through inhibition of HIV-1 RT activity. (C) 2018 Elsevier Masson SAS. All rights reserved.1 aGawali, Rakhi1 aTrivedi, Jay1 aBhansali, Sujit1 aBhosale, Raghunath1 aSarkar, Dhiman1 aMitra, Debashis  uhttps://library.ncl.res.in/content/design-synthesis-docking-studies-and-biological-screening-2-thiazolyl-substituted-23-dihydro