01266nas a2200193   4500008004100000022001400041245014600055210006900201260010600270300001200376490000700388520045000395100001900845700001600864700002000880700002600900700001600926856013000942       2005                        eng d  a0957-416600aStereoselective synthesis of (2S,7S)-7-(4-phenoxymethyl)2-(1-N-hydroxyureidyl-3-butyn-4-yl)oxepane: a potential anti-asthmatic drug candidate0 aStereoselective synthesis of 2S7S74phenoxymethyl21Nhydroxyureidy  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAR  a935-9390 v163 a<p>We have achieved a short, efficient stereoselective synthesis of 7-membered oxepane derivatives with potential against asthma. Highlights of our synthetic strategy are regioselective oxidation of a hydroxyl group and efficient ring closure of an open chain aldehyde to a 2-benzenesulfonyl oxepane derivative with PhSO2H. Surprisingly the cis-isomer showed better activity than the traps-isomer. (C) 2005 Elsevier Ltd. All rights reserved.</p>1 aGurjar, M., K.1 aRao, B., V.1 aKrishna, L., M.1 aChorghade, Mukund, S.1 aLey, S., V.  uhttps://library.ncl.res.in/content/stereoselective-synthesis-2s7s-7-4-phenoxymethyl2-1-n-hydroxyureidyl-3-butyn-4-yloxepane-0