02050nas a2200253   4500008004100000022001400041245012500055210006900180260000800249300001100257490000800268520116800276653001601444653003201460653002201492653002901514100002301543700002401566700001701590700001901607700002301626700001601649856013101665       2020                        eng d  a0301-462200aEffect of tert-alcohol functional imidazolium salts on oligomerization and fibrillization of amyloid beta (1-42) peptide0 aEffect of tertalcohol functional imidazolium salts on oligomeriz  cDEC  a1064800 v2673 a<p>Imidazolium based IL's has gained vast interest in developing biological applications. Oligomerization and fibrillization of amyloid beta (1-42) peptide are mainly responsible for the extra-neuronal deposition of amyloid fibrils in neurodegenerative disorders like Alzheimer's disease (AD). Here, we report an effect of tert-BuOH-functional imidazolium ILs on oligomerization and fibrillization of amyloid beta (1-42) Peptide in vitro. In this study, a series of these [alkyl-(t)OHim][OMs] ILs with methyl sulphonate counter anion by varying alkyl chains were used. Among the seven protic ILs, four showed strong binding and inhibition activity for the formation of amyloid beta (1-42) aggregation by using Thioflavin T fluorescence binding assay. The secondary structural analysis of the peptide, pre-incubated with active ILs shows the loss of ordered beta-sheet amyloid structure. The longer alkyl chain ILs showed that an increased in amyloid binding and hence an inhibition effect on amyloid aggregation was enhanced. Thus, we propose that ILs could be presented as potential candidates for therapeutic intervention against Alzheimer's disease (AD).</p>
10aAggregation10aAmyloid beta (1-42) peptide10aBiofilm inhibitor10aImidazolium ionic liquid1 aSaid, Madhukar, S.1 aNavale, Govinda, R.1 aYadav, Ashok1 aKhonde, Nilesh1 aShinde, Sandip, S.1 aJha, Anjali  uhttps://library.ncl.res.in/content/effect-tert-alcohol-functional-imidazolium-salts-oligomerization-and-fibrillization-amyloid