00932nas a2200157 4500008004100000245007800041210006900119260000800188300001200196490000600208520040000214100002300614700001900637700001400656856010400670 2017 eng d00aTri-tert-butanolamine as an organic promoter in nucleophilic fluorination0 aTritertbutanolamine as an organic promoter in nucleophilic fluor cJAN a118-1220 v23 a

Tri-tert-butanol amine acts as promoter with alkali metal salts in the nucleophilic fluorination of alkylsulfonates. It significantly enhances the reactivity of alkali metal salts with minimum formation of side-products (alkene, ether, and alcohol) com-pared to other catalysts in fluorination reaction. The synergism of tert-alcohol and amine moiety plays a pivotal role in fluorination.

1 aShinde, Sandip, S.1 aKhonde, Nilesh1 aKumar, P. uhttps://library.ncl.res.in/content/tri-tert-butanolamine-organic-promoter-nucleophilic-fluorination02050nas a2200253 4500008004100000022001400041245012500055210006900180260000800249300001100257490000800268520116800276653001601444653003201460653002201492653002901514100002301543700002401566700001701590700001901607700002301626700001601649856013101665 2020 eng d a0301-462200aEffect of tert-alcohol functional imidazolium salts on oligomerization and fibrillization of amyloid beta (1-42) peptide0 aEffect of tertalcohol functional imidazolium salts on oligomeriz cDEC a1064800 v2673 a

Imidazolium based IL's has gained vast interest in developing biological applications. Oligomerization and fibrillization of amyloid beta (1-42) peptide are mainly responsible for the extra-neuronal deposition of amyloid fibrils in neurodegenerative disorders like Alzheimer's disease (AD). Here, we report an effect of tert-BuOH-functional imidazolium ILs on oligomerization and fibrillization of amyloid beta (1-42) Peptide in vitro. In this study, a series of these [alkyl-(t)OHim][OMs] ILs with methyl sulphonate counter anion by varying alkyl chains were used. Among the seven protic ILs, four showed strong binding and inhibition activity for the formation of amyloid beta (1-42) aggregation by using Thioflavin T fluorescence binding assay. The secondary structural analysis of the peptide, pre-incubated with active ILs shows the loss of ordered beta-sheet amyloid structure. The longer alkyl chain ILs showed that an increased in amyloid binding and hence an inhibition effect on amyloid aggregation was enhanced. Thus, we propose that ILs could be presented as potential candidates for therapeutic intervention against Alzheimer's disease (AD).

10aAggregation10aAmyloid beta (1-42) peptide10aBiofilm inhibitor10aImidazolium ionic liquid1 aSaid, Madhukar, S.1 aNavale, Govinda, R.1 aYadav, Ashok1 aKhonde, Nilesh1 aShinde, Sandip, S.1 aJha, Anjali uhttps://library.ncl.res.in/content/effect-tert-alcohol-functional-imidazolium-salts-oligomerization-and-fibrillization-amyloid