02661nas a2200253 4500008004100000022001400041245017300055210006900228260000800297300001100305490000800316520177800324653001502102653001202117653002502129653001202154100001702166700001702183700002002200700001902220700002102239700002202260856012502282 2021 eng d a0927-776500aDesign and synthesis of a new topical agent for halting blood loss rapidly: a multimodal chitosan-gelatin xerogel composite loaded with silica nanoparticles and calcium0 aDesign and synthesis of a new topical agent for halting blood lo cFEB a1114540 v1983 a

Uncontrolled hemorrhage often causes death during traumatic injuries and halting exsanguination topically is a challenge. Here, an efficient multimodal topical hemostat was developed by (i) ionically crosslinking chitosan and gelatin with sodium tripolyphosphate for (ii) fabricating a robust, highly porous xerogel by lyophilization having 86.7 % porosity, by micro-CT and large pores similar to 30 mu m by SEM (iii) incorporating 0.5 mg synthesized silica nanoparticles (SiNPs, 120 nm size, -22 mV charge) and 2.5 mM calcium in xemgel composite that was confirmed by FTIR analysis with peaks at 3372, 986 and 788 cm(-1), respectively. XPS analysis displayed the presence of SiNPs (Si2p peak for silicon) and calcium (Ca2p1, Ca2p3 transition peaks) in the composite. Interestingly, in silico percolation simulation for composite revealed interlinked 800 mu m long-conduits predicting excellent absorption capacity and validated experimentally (640 % of composite dry weight). The composite achieved >16-fold improved blood clotting in vitro than commercial Celox and Gauze through multimodal interaction of its components with RBCs and platelets. The composite displayed good platelet activation and thrombin generation activities. It displayed high compressive strength (2.45 MPa) and withstood pressure during application. Moreover, xerogel composite showed high biocompatibility. In vivo application of xerogel composite to lethal femoral artery injury in rats achieved hemostasis (2.5 min) significantly faster than commercial Celox (3.3 min) and Gauze (4.6 min) and was easily removed from the wound. The gamma irradiated composite was stable till 1.5 yr. Therefore, the xerogel composite has potential for application as a rapid topical hemostatic agent.

10aHemostatic10aPolymer10asilica nanoparticles10aXerogel1 aPatil, Gokul1 aTorris, Arun1 aSuresha, P., R.1 aJadhav, Sachin1 aBadiger, Manohar1 aGhormade, Vandana uhttps://library.ncl.res.in/content/design-and-synthesis-new-topical-agent-halting-blood-loss-rapidly-multimodal-chitosan02073nas a2200265 4500008004100000022001400041245010100055210006900156260000800225300001100233490000800244520120200252653002301454653002501477653001801502653002301520653001901543653001801562100002401580700001701604700001901621700001701640700003101657856011901688 2023 eng d a0927-775700aDouble encapsulation of liquid active compounds using nanoclay reinforced polyurea microcapsules0 aDouble encapsulation of liquid active compounds using nanoclay r cDEC a1325470 v6793 a

In recent years, there has been growing interest in the double encapsulation of drugs, agrochemicals, and fragrances, aiming to achieve the highest encapsulation efficiency and preserve the activity of the encapsulated core over an extended duration. However, when active ingredients in liquid form are double encapsulated, preventing the rupture of primary microcapsules during the second encapsulation process and the leakage of the encapsulated core are major challenges. This report describes a method that utilizes polyurea and starch for successful double encapsulation of dimethyl phthalate (DMP), a liquid insect-repellent, as a model active component. We demonstrate that the incorporation of 3 wt% montmorillonite (MMT) nanoclay strengthens the polyurea wall of the primary microcapsule and prevents its rupture during double encapsulation with starch. This process facilitates the uniform distribution of polyurea microcapsules within the starch matrix and significantly improves the mechanical integrity of the nanocomposite microcapsules embedded in starch. The double-encapsulated system developed in this study significantly reduces the release rate of encapsulated DMP.

10aControlled release10aDouble encapsulation10aMicrocapsules10aMicroencapsulation10aNanocomposites10aStarch matrix1 aAher, Yogeshwar, P.1 aTorris, Arun1 aAdhikari, Benu1 aShukla, Ravi1 aShanmuganathan, Kadhiravan uhttps://library.ncl.res.in/content/double-encapsulation-liquid-active-compounds-using-nanoclay-reinforced-polyurea02473nas a2200277 4500008004100000022001400041245010900055210006900164260000800233490000700241520149100248653001801739653003001757653003301787653002501820653002101845653004501866653003401911100003001945700002001975700001701995700001602012700001802028700002402046856012502070 2025 eng d a1613-681000aDefect-rich CoFe-alloy with engineered carbon support for high-performance rechargeable Zn-air batteries0 aDefectrich CoFealloy with engineered carbon support for highperf cSEP0 v213 a

Defect-rich CoFe-alloy with engineered carbon support is synthesized as a bifunctional cathode, coupled with a modified electrode fabrication technique, for rechargeable zinc-air batteries (RZABs). The CoFe(2:1)/N-rGCNT-catalyst is synthesized by annealing graphene oxide (GO), cobalt and iron acetate, and melamine, leading to the in situ formation of CoFe alloy-encapsulated CNTs. This resulted in a unique layer-separated Fe-rich skin@CoFe alloy decorated nitrogen-doped graphene (NGr) with CoFe-encapsulated CNTs. The interplay of line defects, enhanced conductivity, and electronic modulation underpins electrocatalyst's performance. Electrochemical analysis revealed an onset potential of 955 mV vs RHE, a half-wave potential of 835 mV vs RHE for oxygen reduction reaction (ORR) and an overpotential of 340 mV for oxygen evolution reaction (OER), yielding a Delta E of 0.73 V, comparable to the reported catalysts. The 3D X-ray microtomography simulations suggest improved air permeability of CoFe(2:1)/N-rGCNT facilitates easier gas diffusion, contributing in better device performance. The RZAB with CoFe(2:1)/N-rGCNT-cathode exhibited a peak power density of 171.3 mW cm(-)2, surpassing 140.8 mW cm(-)2 obtained from a cell based on Pt/C-cathode. The Co/N-rGCNT-based battery achieved a stable discharge profile at 10 mA cm(-)2 with a specific capacity of 650 mAh g(-)(1)Zn, and in rechargeable mode, achieved 140 h of high-rate charge-discharge cycling capability.

10a3D tomography10aN-doping10aalloy encapsulated structure10adevice demonstration10agrain boundaries10aoxygen reduction and evolution reactions10arechargeable zinc-air battery1 aKharabe, Geeta, Pandurang1 aBarik, Sidharth1 aTorris, Arun1 aMaria, Anit1 aKumar, Yogesh1 aKurungot, Sreekumar uhttps://library.ncl.res.in/content/defect-rich-cofe-alloy-engineered-carbon-support-high-performance-rechargeable-zn-air02410nas a2200289 4500008004100000022001400041245010600055210006900161260000900230300001200239490000700251520145900258653001901717653001301736653002201749653002601771653001801797100001801815700002001833700003001853700001901883700002301902700001701925700002601942700002701968856012501995 2026 eng d a1060-132500aDesign, synthesis, and adhesive performance evaluation of DOPA-Functionalized polyurethane elastomers0 aDesign synthesis and adhesive performance evaluation of DOPAFunc cJUN  a482-4920 v633 a

Functional polyurethane (PU) hot-melt adhesives were developed through the incorporation of a dopamine-derived chain extender (DADO) into thermoplastic PUs. The DADO monomer was synthesized via a four-step route and successfully integrated into the PU backbone using a one-pot, two-step polymerization involving polycaprolactone-diol and 4,4 `-methylenebis(phenyl isocyanate). Spectral analyses confirmed the formation of urethane linkages and the effective incorporation of catechol moieties. Monomodal molecular weight distributions were obtained through size-exclusion chromatography with Mn ranging from 12,000 to 17,000 g/mol. Thermal analyses demonstrated two-step decomposition behavior and a progressive increase in glass transition temperature with increasing DADO content. Mechanical testing revealed that there was substantial improvement in the tensile strength of these materials from 1.34 MPa for unmodified PU (PU-0) to 14.3 MPa for PU-10. Adhesion performance exhibited a similar trend, with PU-10 attaining the highest lap-shear strength of 3.92 +/- 0.19 MPa on the Al substrate. PU-10 exhibited the highest lap-shear strength of 3.92 +/- 0.19 MPa on aluminum and superior underwater stability with a value of 2.78 +/- 0.47 MPa compared to other formulations. Overall, controlled incorporation of DADO significantly enhances properties, and PU-10 represents the optimal formulation for high-performance hot-melt PU adhesives.

10achain extender10adopamine10ahot-melt adhesive10apolycaprolactone diol10apolyurethanes1 aDavis, Disiya1 aAlam, Md, Shafi1 aBindu, Bhadra, Purushotha1 aLakshmi, Durga1 aMuhammed, Hasin, N1 aTorris, Arun1 aAmbade, Ashootosh, V.1 aNair, Kiran, Sukumaran uhttps://library.ncl.res.in/content/design-synthesis-and-adhesive-performance-evaluation-dopa-functionalized-polyurethane02417nas a2200241 4500008004100000022001400041245010900055210006900164260000800233300001400241490000700255520158900262100001901851700002301870700001901893700002001912700002101932700001701953700001901970700002801989700002702017856013102044 2026 eng d a0897-475600aDynamic janus hydrogen bond mimicry unlocks tough, flexible supramolecular elastomers for strain sensing0 aDynamic janus hydrogen bond mimicry unlocks tough flexible supra cMAR a2699-27110 v383 a

Flexible and wearable electronics demand stretchable sensors with polymer elastomers as key matrixes for mechanical flexibility and durability. However, despite their excellent elasticity, their limited mechanical strength remains a challenge. To address this limitation, in this study, we report the rational design of supramolecular polyurethane elastomers (SPUs) incorporating nucleobase-inspired aminopyrimidinedione with DDA-AAD (G-C mimic) reversible triple hydrogen bonds. This dual-domain architecture gives rise to a durable supramolecular network with enhanced mechanical properties, yielding elastomers that are soft, stretchable, and tough. By tuning of the density of dynamic cross-links, mechanical properties were systematically modulated. SPU-0.5 exhibited a maximum tensile strength of 16.14 MPa, representing a 67-fold strength enhancement over that of SPU-0. Although increasing the aminopyrimidinedione (APD) content reduced elongation, SPU-0.2 retained a high elongation of 1060% and showed the lowest residual strain during cyclic tests. To be of great interest, the activation energy increased with increasing hydrogen bonding content up to SPU-0.1, whereas beyond SPU-0.2 it decreased, likely due to extensive hydrogen bond formation. Furthermore, SPU-0.2-SP, a conductive variant, demonstrated a promising strain-sensing performance even after hundreds of cycles. Overall, the insights gained from this study advance the development of intelligent soft materials and lay the groundwork for next-generation flexible and wearable electronic devices.

1 aLakshmi, Durga1 aWagh, Mahendra, A.1 aSharma, Aakash1 aAlam, Md, Shafi1 aSelvan, Muthamil1 aTorris, Arun1 aMondal, Titash1 aSanjayan, Gangadhar, J.1 aNair, Kiran, Sukumaran uhttps://library.ncl.res.in/content/dynamic-janus-hydrogen-bond-mimicry-unlocks-tough-flexible-supramolecular-elastomers-strain