01747nas a2200205 4500008004100000245018000041210006900221260000800290300001000298490000600308520094500314100002201259700002501281700002301306700002101329700001901350700002501369700002101394856012601415 2014 eng d00aDetermination of optimum values of descriptors to set filters for synthetic tri-pyrrole derivatives (prodiginines) against multi drug resistant strain of plasmodium falciparum0 aDetermination of optimum values of descriptors to set filters fo cJAN a51-590 v13 a

Abstract: In the present study, we have carried out extensive non-linear Quantitative-Structure Activity Relationship (QSAR) analysis to correlate in vitro anti-malarial activity against multi drug resistant strain of Plasmodium falciparum. Forty-three synthetic prodiginines with different structural features were used for their potential antimalarial activity. Linear, bilinear, biexponential and parabolic equations were developed. These equations were compared to determine the optimum values of descriptors for very useful and easily interpretable descriptors. The optimum values of these descriptors could be helpful in finding and optimizing a good lead compound. Obtained correlations reveal that various factors like lipophilicity, molecular weight and number of bonds have non-linear relation with the anti-malarial activity. Keywords: Prodiginines, Anti-Malarial Activity, Optimum/Desirability Values, Hybrid Inverse-QSAR

1 aMasand, Vijay, H.1 aMahajan, Devidas, T.1 aPourbasheer, Eslam1 aBen Hadda, Taibi1 aChauhan, Harsh1 aGajbhiye, Jayant, M.1 aAlafeefy, A., M. uhttps://library.ncl.res.in/content/determination-optimum-values-descriptors-set-filters-synthetic-tri-pyrrole-derivatives02038nam a2200205 4500008004100000245005500041210005400096260001300150300000700163520138300170100002801553700002501581700002201606700002401628700002501652700003201677700001701709700001901726856008701745 2015 eng d00aAdvances and recent applications in LC-MS and HPLC0 aAdvances and recent applications in LCMS and HPLC bElsevier a943 a

Advances and Recent Applications in LC-MS and HPLC presents the most recent developments in liquid chromatography and mass spectrometry techniques. The book’s content reaches across a range of disciplines and cites several case studies to effectively capture the advanced applications that make LC-MS and HPLC multifunctional and exacting techniques. Liquid chromatography and mass spectrometry systems generate chromatograms of column peaks and can provide molecular weights of separated materials and their solvent complexes. However, while these systems can provide structural information to confirm the identity of the compounds separated, the process is very expensive. This book provides identification of simple compounds resulting from fragmentation studies and their subsequent results, offering the reader access to information unavailable elsewhere and allowing researchers to avoid incurring the costs associated with obtaining the hands-on results that LC-MS systems generate. Applicable to chemical analysis, bioanalysis, and medicinal chemistry, as well as pharmaceutical science, synthetic chemistry, and industrial chemistry, Advances and Recent Applications in LC-MS and HPLC is a multidisciplinary reference that arms scientists with the latest research. Detailed case studies enable researchers to make the book's concepts immediately implementable.

1 aAzharuddin, Quazi, Syed1 aMahajan, Devidas, T.1 aMasand, Vijay, H.1 aAlafeefy, Ahmed, M.1 aGajbhiye, Jayant, M.1 aEl-Sayed, Nahed, Nasser Eid1 aWajid, Abdul1 aMohammad, Noor uhttps://library.ncl.res.in/content/advances-and-recent-applications-lc-ms-and-hplc00849nas a2200157 4500008004100000245009700041210006900138260000800207300001400215520025400229100002500483700001700508700001700525700002500542856012400567 2015 eng d00aAnalysis of pantaprazole na monohydrate and sesquihydrate by powder x-ray diffraction (PXRD)0 aAnalysis of pantaprazole na monohydrate and sesquihydrate by pow cJAN a320 - 3233 a

Pantaprazole Na monohydrate and sesquihydrate were characterized by PXRD.significant difference in the diffraction patterns of Pantaprazole Na hydrates. The sesquihydrate contains all the diffraction peaks of monohydrate in addition to peaks.

1 aMahajan, Devidas, T.1 aMohmad, Noor1 aRaut, D., M.1 aGajbhiye, Jayant, M. uhttps://library.ncl.res.in/content/analysis-pantaprazole-na-monohydrate-and-sesquihydrate-powder-x-ray-diffraction-pxrd