02112nas a2200241   4500008004100000245013000041210006900171260000800240300001200248490000800260520125600268100002401524700002601548700002601574700002301600700002401623700001801647700001901665700001801684700002001702700001901722856012901741       2016                        eng d00aDesign, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents0 aDesign synthesis and biological evaluation of novel azaspiro ana  cOCT  a475-4870 v1223 a<p>The design, synthesis and antimicrobial evaluation of a novel series of azaspiro analogues of linezolid (1) have been described. Linezolid comprises of a morpholine ring which is known for its metabolism related liabilities. Therefore, the key modification made in the linezolid structure was the replacement of morpholine moiety with its bioisostere, 2-oxa-6-azaspiro[3.3]heptane. Furthermore, the replacement of N-acetyl terminal of 1 with various aromatic or aliphatic functionalities was carried out. The title compounds were evaluated against a panel of Gram-positive and Gram-negative bacteria and Mycobacterium tuberculosis. Subsequent structure-activity relationship (SAR) studies identified several compounds with mixed antibacterial and antitubercular profiles. Compound 22 (IC50 0.72, 0.51, 0.88, 0.49 mu g/mL for Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, respectively) exhibited similar antibacterial profile as I. The N-acetyl derivative 18 was similar to 1 in antitubercular profile. Thus, the present study successfully demonstrated the use of azaspiro substructure in the medicinal chemistry of antibacterial and antitubercular agents. (C) 2016 Elsevier Masson SAS. All rights reserved.</p>1 aGadekar, Pradip, K.1 aRoychowdhury, Abhijit1 aKharkar, Prashant, S.1 aKhedkar, Vijay, M.1 aArkile, Manisha, A.1 aManek, Hardik1 aSarkar, Dhiman1 aSharma, Rajiv1 aVijayakumar, V.1 aSarveswari, S.  uhttps://library.ncl.res.in/content/design-synthesis-and-biological-evaluation-novel-azaspiro-analogs-linezolid-antibacterial02779nas a2200193   4500008004100000245014500041210006900186260000800255300001500263490000600278520205100284100002002335700002202355700002202377700001702399700002002416700001702436856013202453       2017                        eng d00aAll-solid-state-supercapacitor possessing a non-aqueous gel polymer electrolyte prepared using a UV-assisted in situ polymerization strategy0 aAllsolidstatesupercapacitor possessing a nonaqueous gel polymer   cMAY  a 8461-84760 v53 a<p>In this work, we report the synthesis of a high ionic conducting and mechanically stable non-aqueous gel polymer electrolyte (GPE) in which a liquid electrolyte (LiClO4/propylene carbonate) is entrapped in a poly(2-hydroxy-3-phenoxy propyl acrylate) matrix by a UV assisted in situ polymerisation strategy. Unlike conventional dry and quasi-solid non-aqueous GPEs, our system (H-P-L-3M-80%) shows an excellent ionic conductivity of 4.7 x 10(-3) S cm(-1), a value which is comparable to those of non-aqueous liquid electrolytes. The high mechanical stability of GPE arises due to the covalent cross-links present in the polymer matrix as well as the reversible non-covalent cross-links between the solvent and the polymer matrix through the Li+ cations. Subsequently, the GPE has been prepared in situ on the inner and the outer surface of the electrode material to fabricate a 2.0 V supercapacitor device with a high mass loading (3.8 mg cm(-2)) of the active material (YP-80F, a high surface area porous carbon). The device shows an equivalent series resistance (ESR) as low as 2.2 Omega, which is close to that of the device fabricated from the corresponding liquid electrolyte and is far better than those of the devices evolved from conventional GPEs and dry polymer electrolytes. The mass specific capacitance of 113 F g(-1) obtained at a current density of 2 mA cm(-2) shows 81% retention even at a high current density of 20 mA cm(-2). The scalability of the strategy is demonstrated by fabricating a large area (area = 16 cm(2), loading = 4.0 mg cm(-2)) all-solid-state flexible-supercapacitor (H-P-L-3M-S-4.0) device which can be operated at a potential window of 2.5 V. The device was found to show a mass specific capacitance of 111 F g(-1) at a current density of 1 mA cm(-2) (0.25 A g(-1)), all the while, retaining a very low ESR of 2.2 Omega. The potential of the strategy to mimic the liquid-like electrode-electrolyte interface, augmented with the ability to tune further, opens up new horizons for energy storage devices.</p>1 aVijayakumar, V.1 aAnothumakkool, B.1 aTorris, A., T. A.1 aNair, S., B.1 aBadiger, M., V.1 aKurungot, S.  uhttps://library.ncl.res.in/content/all-solid-state-supercapacitor-possessing-non-aqueous-gel-polymer-electrolyte-prepared-using