01440nas a2200169   4500008004100000245008100041210007100122260000800193300001800201490000700219520084100226100002001067700001801087700002801105700002001133856011701153       2013                        eng d00aCobalt-catalyzed C–H bond functionalizations with aryl and alkyl chlorides0 aCobaltcatalyzed C–H bond functionalizations with aryl and alkyl   cAUG  a10605–106100 v193 a<p>Inexpensive cobalt catalysts derived from N-heterocylic carbenes (NHC) allowed efficient catalytic C[BOND]H bond arylations on heteroaryl-substituted arenes with widely available aryl chlorides, which set the stage for the preparation of sterically hindered tri-ortho-substituted biaryls. Likewise, challenging direct alkylations with β-hydrogen-containing primary and even secondary alkyl chlorides proceeded on pyridyl- and pyrimidyl-substituted arenes and heteroarenes. The cobalt-catalyzed C[BOND]H bond functionalizations occurred efficiently at ambient reaction temperature with excellent levels of site-selectivities and ample scope. Mechanistic studies highlighted that electron-deficient aryl chlorides reacted preferentially, while the arenes kinetic C[BOND]H bond acidity was found to largely govern their reactivity.</p>1 aPunji, Benudhar1 aSong, Weifeng1 aShevchenko, Grigory, A.1 aAckermann, Lutz  uhttps://library.ncl.res.in/content/cobalt-catalyzed-c%E2%80%93h-bond-functionalizations-aryl-and-alkyl-chlorides