01682nas a2200205   4500008004100000022001400041245011900055210006900174260000800243300001400251490000700265520092200272100002101194700002901215700002501244700002301269700002601292700002801318856013001346       2023                        eng d  a0022-326300aCatalyst-assisted selective vinylation and methylallylation of a quaternary carbon center using tert-butyl acetate0 aCatalystassisted selective vinylation and methylallylation of a   cJUL  a9686-97030 v883 a<p>
	The In-(OTf)(3)-catalyzed &amp; alpha;-vinylationof varioushydroxy-functionalized quaternary carbon centers using in situ generatedisobutylene from tert-butyl acetate is presentedas a novel synthetic methodology. Moreover, tert-butylacetate is a nonflammable feed stock and is a readily available sourcefor the in situ production of vinyl substituents, as demonstratedby the vinylation reaction with quaternary hydroxy/methoxy compounds.Moreover, an excellent selectivity for methylallylation over vinylationwas obtained with Ni-(OTf)(2) as a catalyst. In the case ofperoxyoxindole, methylallyl-functionalized 1,4-benzoxazin-3-one derivativeswere formed through the sequential rearrangement of peroxyoxindolefollowed by the nucleophilic attack by isobutylene. The detailed mechanismfor this reaction and rationalization for the selectivity are providedusing kinetics and density functional theory studies.</p>
1 aMohanta, Nirmala1 aSamal, Pragnya, Paramita1 aPandey, Akanksha, M.1 aMondal, Shankhajit1 aKrishnamurty, Sailaja1 aGnanaprakasam, Boopathy  uhttps://library.ncl.res.in/content/catalyst-assisted-selective-vinylation-and-methylallylation-quaternary-carbon-center-using02330nas a2200217   4500008004100000022001400041245020900055210007000264260000800334490000700342520144700349653002001796653002401816653002601840653002501866653002601891100001801917700001801935700002801953856013101981       2025                        eng d  a2193-580700aContinuous flow β-zeolite catalysed regioselective alkylation of naphthols using alcohols for synthesis of peroxynaphthalen-2(1H)-one, Azidonaphthalen-2(1H)-one and Fluoronaphthalen-2(1H)-one derivatives0 aContinuous flow βzeolite catalysed regioselective alkylation of   cAPR0 v143 a<p>
	Functionalized naphthols are prominent scaffolds in organic synthesis and materials chemistry. Herein, we demonstrated continuous flow alkylation of alpha- and beta-naphthols by using various primary and secondary benzylic alcohols in the presence of environmentally benign granular beta-zeolite as a reusable catalyst. For a variety of beta-naphthols, the respective alkylated products with good regioselectivity were obtained in high yields under mild reaction conditions. This protocol proceeded via the classical Friedel-Crafts type alkylation process and generated stable carbocations as intermediates. Applying this protocol, versatile naphthol derivatives have been synthesized using primary and secondary benzylic alcohols (50 and 44 examples in batch and continuous flow process, respectively), with good yields. Key advantages of this process includes rapid and efficient transformation, facilitates gram-scale synthesis, and generates water as the sole by-product. The most significant advantage is the continuous reusability of granular beta-zeolite, which further emphasizes the sustainability of the method. The application of alkylated naphthols for quaternary functionalization was demonstrated through peroxidation, azidation, and halogenation reactions under the continuous flow module, which yielded the respective peroxynaphthalen-2(1H)-one, azidonaphthalen-2(1H)-one and fluoronaphthalen2(1H)-one derivatives.</p>
10acontinuous flow10aMultigram Synthesis10aReusable beta-zeolite10aSustainable Appraoch10aTransition metal free1 aLondhe, Gokul1 aBokade, Vijay1 aGnanaprakasam, Boopathy  uhttps://library.ncl.res.in/content/continuous-flow-%CE%B2-zeolite-catalysed-regioselective-alkylation-naphthols-using-alcohols