00519nas a2200121 4500008004100000245011800041210006900159260000800228300000900236490000600245100001800251856012800269 2010 eng d00aApplication of nanotechnology for detection and decontamination of organophosphorus pesticides and warfare agents0 aApplication of nanotechnology for detection and decontamination  cJUN a1-170 v81 aNigam, Preeti uhttps://library.ncl.res.in/content/application-nanotechnology-detection-and-decontamination-organophosphorus-pesticides-and01843nas a2200181 4500008004100000245010200041210006900143260000800212520117100220100001801391700002501409700002101434700002301455700002001478700001801498700001901516856012601535 2014 eng d00aAptamer functionalized multifunctional fluorescent nanotheranostic platform for pancreatic cancer0 aAptamer functionalized multifunctional fluorescent nanotheranost cDEC3 aThis study explores the potential of aptamer functionalized and fluorescent silver nanoparticles (AgNPs) labeled human serum albumin nanoparticles for drug delivery and bioimaging. Nanotechnology is certainly the most promising research arena in recent years and different fields of biotechnology, medicine and agricultural have been deeply benefited by the enormous advantages of nanotechnology. In recent years, synthesis of nanoparticles via eco-friendly methods has attained a lot of interest and silver nanoparticles are synthesized extensively due to their size tunable properties and vast applicability in different areas. In this study we have explored green synthesized fluorescent silver nanoparticles as a novel bioimaging agent for pancreatic cancer. Capsaicin, a plant phytochemical found in red chilli pepper was encapsulated in aptamer MUC-1 coupled albumin nanoparticles and it was observed that the nanoformulation significantly enhanced the bioavailability and sustained release property of the drug to pancreatic cancer cells in-vitro. Meanwhile AgNPs mediated excellent bioimaging has enhanced the efficacy of our system as drug delivery vehicle.1 aNigam, Preeti1 aWaghmode, Shobha, A.1 aYeware, Amar, M.1 aNawale, Laxman, U.1 aDagde, Priyanka1 aDudhane, Amol1 aSarkar, Dhiman uhttps://library.ncl.res.in/content/aptamer-functionalized-multifunctional-fluorescent-nanotheranostic-platform-pancreatic02008nas a2200205 4500008004100000022001400041245011900055210006900174260011000243300001400353490000600367520117900373100001801552700002101570700002001591700002301611700001801634700001901652856013101671 2014 eng d a2050-750X00aGraphene quantum dots conjugated albumin nanoparticles for targeted drug delivery and imaging of pancreatic cancer0 aGraphene quantum dots conjugated albumin nanoparticles for targe aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJUN a3190-31950 v23 a

Pancreatic cancer is considered to be the deadliest of all cancers due to its poor prognosis and resistance to conventional therapies. In this study, the potential of hyaluronic acid functionalized and green fluorescent graphene quantum dot (GQD)-labeled human serum albumin nanoparticles for pancreatic cancer specific drug delivery and bioimaging was explored. GQDs with tunable fluorescence properties and biocompatibility have attracted much more interest in recent years as compared to their metal semiconductor counterparts. We adopted lawsone (2-hydroxy-1,4-naphthoquinone) as a novel reducing agent for the synthesis of quantum dots and, in addition to excellent fluorescence of the synthesized GQDs, a good quantum yield of similar to 14% was also obtained. Gemcitabine, the most preferred drug for pancreatic cancer treatment, was encapsulated in albumin nanoparticles, and it was observed that our nanoformulation significantly enhanced the bioavailability and sustained release property of the drug to pancreatic cancer cells in vitro. Moreover, the GQD-mediated bioimaging was excellent and enhanced the efficacy of our system as a drug delivery vehicle.

1 aNigam, Preeti1 aWaghmode, Shobha1 aLouis, Michelle1 aWangnoo, Shishanka1 aChavan, Pooja1 aSarkar, Dhiman uhttps://library.ncl.res.in/content/graphene-quantum-dots-conjugated-albumin-nanoparticles-targeted-drug-delivery-and-imaging-001427nas a2200133 4500008004100000245010100041210006900142260000800211490000600219520089900225100001801124700001901142856013201161 2015 eng d00aMultifunctional silica nanoparticles for pancreatic cancer specific drug delivery and bioimaging0 aMultifunctional silica nanoparticles for pancreatic cancer speci cJUN0 v23 a

Mesoporous silica nanoparticles (MSN) have attracted increasing interest as drug carriers due to their biocompatibility and robustness. In this analysis we explored the potential of MSN as nanotheranostic platform for pancreatic cancer specific drug delivery and bioimaging. Pancreatic cancer is the most fatal cancer and due to its high mortality and low prognosis it is imperative to develop new methods for early diagnosis and therapy of this cancer. Though traditionally organic dyes, quantum dots and fluorescent agents are used for bioimaging but here we have utilized graphene quantum dots (GQDs) for bioimaging due to their superior biocompatibility and fluorescence properties. MSN were loaded with gemcitabine; the most preferred drug for pancreatic cancer. MSN and GQDs were characterized by SEM, TEM, FT-IR etc and the efficacy of nanoformulation was determined by MTT assay.

1 aNigam, Preeti1 aSarkar, Dhiman uhttps://library.ncl.res.in/content/multifunctional-silica-nanoparticles-pancreatic-cancer-specific-drug-delivery-and-bioimaging01207nas a2200229 4500008004100000022001400041245008800055210006900143260010600212300001400318490000700332520037200339653002400711653001500735653001400750653001700764100002100781700002200802700001800824700002500842856011000867 2015 eng d a0040-403900aSynthesis of (+/-) debenzoyl analogs of norsampsones as potential anticancer agents0 aSynthesis of debenzoyl analogs of norsampsones as potential anti aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcSEP a5235-52370 v563 a

Synthesis of (+/-) debenzoyl analogs of norsampsones 1 and 2 is reported starting from commercially available 1,3-cyclohexadione in six steps with overall yields of 37% and 36%, respectively. Compounds 1 and 2 were tested for their anticancer activity and showed moderate anticancer activity against HeLa cell lines. (C) 2015 Elsevier Ltd. All rights reserved.

10aAcylphloroglucinols10aAnticancer10aDebenzoyl10aNorsampsones1 aJadhav, Amol, R.1 aThombal, Raju, S.1 aNigam, Preeti1 aJadhav, Vrushali, H. uhttps://library.ncl.res.in/content/synthesis-debenzoyl-analogs-norsampsones-potential-anticancer-agents-001475nas a2200133 4500008004100000245007800041210006900119260001300188300001200201520099400213100001801207700001801225856009801243 2020 eng d00aNanorobots for in vivo monitoring: the future of nano-implantable devices0 aNanorobots for in vivo monitoring the future of nanoimplantable  bSpringer a227-2523 a

Innovation is important for the healthcare system advancement, in order to continue delivering the high-quality care at an affordable cost to the society. It can be achieved by nonconventional thinking, tapping into creative minds, and extensive collaborative work to make better use of existing facilities and designing new technologies. Nanorobotics is such an innovation that can revolutionize the current face of medicine and biomedical sciences with their state-of-the-art technology. Improved outcomes of nanorobots-based treatments for diabetes, drug delivery for pancreatic and ovarian cancer, and laparoscopic treatment of skin cancer have already been reported. This book chapter will cover the recent advancements of this emerging field with their biomedical applications.

1 aGandhi, Mamta1 aNigam, Preeti uhttps://library.ncl.res.in/content/nanorobots-vivo-monitoring-future-nano-implantable-devices