01819nas a2200229   4500008004100000022001400041245011000055210006900165260011000234300001200344490000700356520091600363100002601279700002201305700002601327700002001353700001901373700002101392700002101413700002501434856013001459       2013                        eng d  a1463-926200aFluorescent sophorolipid molecular assembly and its magnetic nanoparticle loading: a pulsed laser process0 aFluorescent sophorolipid molecular assembly and its magnetic nan  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJAN  a943-9530 v153 a<p>We report realization of strong green fluorescence in a fully biocompatible highly spherical mesoscale molecular assembly of sophorolipid created by pulsed UV laser processing of a water-based dispersion of sophorolipid. Remarkably, the said fluorescence is totally absent in the original molecule of sophorolipid and is thus the property of the pulsed laser induced modifications in the molecule and the assembly. We have separately examined the consequences of laser irradiation for glucose and oleic acid components which form the sophorolipid. This fluorescence character appears to be driven by the oleic acid component while the assembly process is assisted by the glucose component. Importantly the laser synthesized mesostructures can be easily redispersed in an aqueous medium after being dried and can also be loaded with magnetic nanoparticles (magnetite) for inducing the hyperthermia effect.</p>1 aSingh, Pradeep, Kumar1 aMukherji, Ruchira1 aJoshi-Navare, Kasturi1 aBanerjee, Abhik1 aGokhale, Rohan1 aNagane, Satyawan1 aPrabhune, Asmita1 aOgale, Satishchandra  uhttps://library.ncl.res.in/content/fluorescent-sophorolipid-molecular-assembly-and-its-magnetic-nanoparticle-loading-pulsed-001713nas a2200193   4500008004100000022001400041245013600055210006900191260011000260300001600370490000600386520089000392100002601282700001701308700002701325700002101352700002501373856012101398       2014                        eng d  a2046-206900aFrom micron to nano-curcumin by sophorolipid co-processing: highly enhanced bioavailability, fluorescence, and anti-cancer efficacy0 aFrom micron to nanocurcumin by sophorolipid coprocessing highly   aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcNOV  a60334-603410 v43 a<p>Co-sonication of curcumin and acidic sophorolipid in aqueous solution is shown to lead to a dramatic enhancement of curcumin bioavailability through size reduction and encapsulation. The interaction between the two is studied and discussed based on optical absorption, photoluminescence, dynamic light scattering (DLS), zeta potential, FE-SEM, TEM, Infrared spectroscopy and X-ray diffraction measurements. The cytotoxicity effects of curcumin on breast cancer cell lines, MCF-7 and MDA-MB-231, are shown to be significantly enhanced by the formation of its complex with sophorolipid. The relative cytotoxicity of curcumin with its SL(A) complex is more due to the presence of the glucose moiety. The results further suggest that sophorolipid based formulations, which solubilize and nano-encapsulate curcumin after lipid digestion, show great potential for curcumin cell entry.</p>1 aSingh, Pradeep, Kumar1 aWani, Kirtee1 aKaul-Ghanekar, Ruchika1 aPrabhune, Asmita1 aOgale, Satishchandra  uhttps://library.ncl.res.in/content/micron-nano-curcumin-sophorolipid-co-processing-highly-enhanced-bioavailability-200829nas a2200181   4500008004100000022001400041245016000055210006900215260011000284300001000394490000600404100002600410700001700436700002700453700002100480700002500501856012100526       2015                        eng d  a2046-206900aFrom micron to nano-curcumin by sophorolipid co-processing: highly enhanced bioavailability, fluorescence, and anti-cancer efficacy (vol 4, pg 60334, 2014)0 aFrom micron to nanocurcumin by sophorolipid coprocessing highly   aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcFEB  a220750 v51 aSingh, Pradeep, Kumar1 aWani, Kirtee1 aKaul-Ghanekar, Ruchika1 aPrabhune, Asmita1 aOgale, Satishchandra  uhttps://library.ncl.res.in/content/micron-nano-curcumin-sophorolipid-co-processing-highly-enhanced-bioavailability-101952nas a2200253   4500008004100000022001400041245010000055210006900155260000800224300001200232490000700244520113400251653002101385653001601406653001201422653001701434653001801451100001701469700002601486700001901512700002001531700002101551856012601572       2019                        eng d  a0973-129600aFormulation and evaluation of wound healing activity of sophorolipid-sericin gel in wistar rats0 aFormulation and evaluation of wound healing activity of sophorol  cAPR  a123-1270 v153 a<p>Sericin is a useful by-product of silk processing and is resistant to oxidation and ultraviolet and can absorb and release moisture easily. Sericin has biological activities such as antibacterial, antioxidant, and tyrosinase inhibition. Sophorolipids are microbial extracellular glycolipids produced by resting cells of Candida bombicola. Sophorolipids show excellent skin compatibility and also have antibacterial property. In this study, we have developed a novel formulation consisting of sericin and sophorolipid with calcium alginate as a binding agent. Since both the ingredients are biocompatible and biodegradable, the formulation was tested for wound healing in Wistar rats. A commercial ointment povidone was used as control. The animal group, treated with sericin and sophorolipid cream, showed fast contraction, rapid closure, and healing when compared with control and commercial ointment. These observations were validated with histopathological studies where more fibroblast proliferation, angiogenesis, and keratinization were observed. This is a green, cost-effective formulation for fast wound healing.</p>
10aBiocompatibility10aformulation10asericin10aSophorolipid10awound Healing1 aMore, Snehal1 aKoratkar, Santosh, S.1 aKadam, Navnath1 aAgawane, Sachin1 aPrabhune, Asmita  uhttps://library.ncl.res.in/content/formulation-and-evaluation-wound-healing-activity-sophorolipid-sericin-gel-wistar-rats