01913nas a2200193   4500008004100000022001400041245011000055210006900165260009000234300002500324490000600349520110800355100002401463700002401487700003001511700002401541700002501565856012901590       2015                        eng d  a2041-172300aReversed reactivity of anilines with alkynes in the rhodium-catalysed C-H activation/carbonylation tandem0 aReversed reactivity of anilines with alkynes in the rhodiumcatal  aMACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLANDbNATURE PUBLISHING GROUPcOCT  aArticle Number: 85910 v63 a<p>Development of multicatalytic approach consisting of two or more mechanistically distinct catalytic steps using a single-site catalyst for rapid and straightforward access of structurally complex molecules under eco-benign conditions has significance in contemporary science. We have developed herein a rhodium-catalysed C-H activation strategy which uses an unprotected anilines and an electron-deficient alkynes to C-C bonded products as a potential intermediate in contrast to the archetypical C-N bonded products with high levels of regioselectivity. This is followed by carbonylation of C-H bond activated intermediate and subsequent annulation into quinolines has been described. This rhodium-catalysed auto-tandem reaction operates under mild, environmentally benign conditions using water as the solvent and CO surrogates as the carbonyl source with the concomitant generation of hydrogen gas. The strategy may facilitate the development of new synthetic protocols for the efficient and sustainable production of chemicals in an atom-economic way from simple, abundant starting materials.</p>1 aMidya, Siba, Prasad1 aSahoo, Manoj, Kumar1 aLandge, Vinod, Gokulkrish1 aRajamohanan, P., R.1 aBalaraman, Ekambaram  uhttps://library.ncl.res.in/content/reversed-reactivity-anilines-alkynes-rhodium-catalysed-c-h-activationcarbonylation-tandem01418nas a2200181   4500008004100000022001400041245009500055210006900150260007500219300001600294490000700310520068400317100003001001700002401031700003001055700002501085856012601110       2015                        eng d  a1433-785100aTransition-metal-catalyzed hydrogen-transfer annulations: access to heterocyclic scaffolds0 aTransitionmetalcatalyzed hydrogentransfer annulations access to   aPOSTFACH 101161, 69451 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcSEP  a11022-110340 v543 a<p>The ability of hydrogen-transfer transition-metal catalysts, which enable increasingly rapid access to important structural scaffolds from simple starting materials, has led to a plethora of research efforts on the construction of heterocyclic scaffolds. Transition-metal-catalyzed hydrogen-transfer annulations are environmentally benign and highly atom-economical as they release of water and hydrogen as by-product and utilize renewable feedstock alcohols as starting materials. Recent advances in this field with respect to the annulations of alcohols with various nucleophilic partners, thus leading to the formation of heterocyclic scaffolds, are highlighted herein.</p>1 aNandakumar, Avanashiappan1 aMidya, Siba, Prasad1 aLandge, Vinod, Gokulkrish1 aBalaraman, Ekambaram  uhttps://library.ncl.res.in/content/transition-metal-catalyzed-hydrogen-transfer-annulations-access-heterocyclic-scaffolds00940nas a2200181   4500008004100000245008000041210006900121260000800190300001600198490000700214520030700221100003000528700002400558700002400582700002000606700002500626856010700651       2015                        eng d00aWell-defined palladium(II) complexes for ligand enabled C(sp3)-alkynylation0 aWelldefined palladiumII complexes for ligand enabled Csp3alkynyl  cJUL  a15382-153860 v443 a<p>The first example of ligand-enabled C(sp3)-alkynylation of 8-methylquinoline is reported. The reaction is catalysed by well-defined Pd(II) complexes. The present C(sp3)-alkynylation has a broad substrate scope as well as functional group tolerance and proceeds efficiently under mild conditions.</p>1 aLandge, Vinod, Gokulkrish1 aSahoo, Manoj, Kumar1 aMidya, Siba, Prasad1 aJaiswal, Garima1 aBalaraman, Ekambaram  uhttps://library.ncl.res.in/content/well-defined-palladiumii-complexes-ligand-enabled-csp3-alkynylation00978nas a2200157   4500008004100000245008100041210007100122260000800193300001400201490000700215520040800222100003000630700002000660700002500680856011500705       2016                        eng d00aCobalt-catalyzed bis-alkynylation of amides via double C–H bond activation0 aCobaltcatalyzed bisalkynylation of amides via double C–H bond ac  cFEB  a812–8150 v183 a<p>The first example of cobalt-catalyzed selective bis-alkynylation of amides via double C–H bond activation with the directing assistance of a removable bidentate auxiliary is reported. The developed alkynylation strategy is simple, efficient, and tolerant of various functional groups including ether, amine, halides, and heterocyclic motifs. The reaction can be scaled up under mild conditions.</p>1 aLandge, Vinod, Gokulkrish1 aJaiswal, Garima1 aBalaraman, Ekambaram  uhttps://library.ncl.res.in/content/cobalt-catalyzed-bis-alkynylation-amides-double-c%E2%80%93h-bond-activation01330nas a2200193   4500008004100000245008000041210007100121260000800192300001400200490000700214520048400221653019300705100003000898700002400928700002000952700002300972700002500995856011601020       2016                        eng d00aExpedient cobalt-catalyzed C–H alkynylation of (enantiopure) benzylamines0 aExpedient cobaltcatalyzed C–H alkynylation of enantiopure benzyl  cOCT  a5252-52550 v183 a<p>A unified strategy for cobalt-catalyzed ortho-C-H bond alkynylation of benzylamines is reported. Simple, commercially available CoBr2 was used as a cobalt source. The developed alkynylation strategy is robust and efficient and has a broad substrate scope including 1 degrees, 2 degrees, and 3 degrees benzylamines. The mechanistic study shows that C-H bond cleavage is reversible, and the kinetic study illustrates that the rate of reaction depends solely on the catalyst.</p>10aTerminal Alkynes; Bond Activation; Directed Functionalization;Aminoquinoline Benzamides; Ortho-C(Sp(2))-H Bonds; Mechanistic Insights; Selective Access; Carbon-Hydrogen; Nickel; Annulation1 aLandge, Vinod, Gokulkrish1 aMidya, Siba, Prasad1 aRana, Jagannath1 aShinde, Dinesh, R.1 aBalaraman, Ekambaram  uhttps://library.ncl.res.in/content/expedient-cobalt-catalyzed-c%E2%80%93h-alkynylation-enantiopure-benzylamines01259nas a2200193   4500008004100000245015300041210006900194260000800263300001400271490000600285520048300291100003000774700002500804700002000829700002400849700002400873700002500897856014300922       2016                        eng d00aNickel-catalyzed direct alkynylation of C(sp2)-H bonds of amides: an “inverse sonogashira strategy” to ortho-alkynylbenzoic acids. just accepted0 aNickelcatalyzed direct alkynylation of Csp2H bonds of amides an   cOCT  a1946-19510 v63 a<p>Nickel-catalyzed direct alkynylation of C(sp2)–H bonds of amides using commercially available, inexpensive 8-aminoquinoline as a removable bidentate directing group is described. The present ortho-alkynylation has a broad substrate scope, functional group tolerance and high regiocontrol, and can be scaled up. The efficiency and selectivity of this strategy provide sustainable routes to a diverse array of ortho-alkynylbenzoic acids under Ni(II)-catalyzed conditions.</p>1 aLandge, Vinod, Gokulkrish1 aShewale, Chinmay, H.1 aJaiswal, Garima1 aSahoo, Manoj, Kumar1 aMidya, Siba, Prasad1 aBalaraman, Ekambaram  uhttps://library.ncl.res.in/content/nickel-catalyzed-direct-alkynylation-csp2-h-bonds-amides-%E2%80%9Cinverse-sonogashira-strategy%E2%80%9D01188nas a2200169   4500008004100000245011900041210006900160260000800229300001400237490000700251520053500258100002000793700003000813700002300843700002500866856012700891       2016                        eng d00aSustainable Iron-catalyzed direct imine formation by acceptorless dehydrogenative coupling of alcohols with amines0 aSustainable Ironcatalyzed direct imine formation by acceptorless  cMAY  a3232-32380 v183 a<p>The Acceptorless Dehydrogenative Coupling (ADC) of alcohols with amines is reported using a heterogeneous Fe-catalyst. The reaction operates under mild conditions with the liberation of dihydrogen and water as the byproducts. The developed ADC strategy is simple, efficient, exhibits wide functional group tolerance and can be scaled up. The present catalytic approach possesses a dual role; acting as a catalyst as well as being magnetically separable. The sustainable reuse of a heterogeneous iron catalyst is also shown.</p>1 aJaiswal, Garima1 aLandge, Vinod, Gokulkrish1 aJagadeesan, Dinesh1 aBalaraman, Ekambaram  uhttps://library.ncl.res.in/content/sustainable-iron-catalyzed-direct-imine-formation-acceptorless-dehydrogenative-coupling