01491nas a2200169   4500008004100000245009900041210007100140260000800211300001600219490000700235520085000242100002201092700002201114700002201136700002301158856014001181       2016                        eng d00aContinuous flow doebner–miller reaction and isolation using continuous stirred tank reactors0 aContinuous flow doebner–miller reaction and isolation using cont  cAUG  a1621–16250 v203 a<p>Continuous flow Doebner–Miller synthesis of different quinaldines from respective anilines is demonstrated using sulfuric acid as a homogeneous catalyst. The extent of reaction was monitored for various parameters, namely, temperature, residence time, mole ratio of sulfuric acid to substrate, mole ratio of crotonaldehyde to substrate, and so forth. Continuous stirred reactors in series were used as a preferred configuration for this rection that generates byproduct in the form of sticky solid material. The approach has been extended for six different anilines, and the results are compared with batch reactions. Continuous stirred reactors in series with distributed dosing of crotonaldehyde facilitated a continuous flow reaction with lower byproduct formation, increased yields, and continuous workup and is a scalable approach.</p>1 aYadav, Maruti, B.1 aKulkarni, Sourabh1 aJoshi, Ramesh, A.1 aKulkarni, Amol, A.  uhttps://library.ncl.res.in/content/continuous-flow-doebner%E2%80%93miller-reaction-and-isolation-using-continuous-stirred-tank-reactors