01313nas a2200181 4500008004100000245010100041210006900142260000800211300001400219490000700233520065000240100002600890700002900916700002200945700002400967700002200991856011801013 2016 eng d00aSelective synthesis of N-unsubstituted and N-arylindoles by the reaction of arynes with azirines0 aSelective synthesis of Nunsubstituted and Narylindoles by the re cSEP a8604-86110 v813 a

The transition-metal-free and temperature-dependent highly selective reaction of arynes with 2H-azirines allowing the synthesis of either N-unsubstituted or N-arylindoles has been developed. At 60 degrees C, arynes generated from 2-(trimethylsilyl)aryl triflates smoothly insert into 2H-azirines to form 2,3-diarylindoles with high selectivity. Interestingly, when the reaction was performed at -10 degrees C, the selectivity was switched to the formation of 1,2,3-triarylindoles in good yields.

1 aThangaraj, Manikandan1 aBhojgude, Sachin, Suresh1 aJain, Shailja", "1 aGonnade, Rajesh, G.1 aBiju, Akkattu, T. uhttps://library.ncl.res.in/content/selective-synthesis-n-unsubstituted-and-n-arylindoles-reaction-arynes-azirines