03028nas a2200169 4500008004100000245016800041210007100209260000800280520230800288100002502596700001802621700001902639700002102658700002802679700001802707856013302725 2012 eng d00aSelf–assembled histidine acid phosphate nanocapsules as templates for multifunctional hollow platinum nanospheres in ionic liquid [BMIM][BF 4 ] for drug delivery0 aSelf–assembled histidine acid phosphate nanocapsules as template cJAN3 a

During the past few decades, the design and fabrication of nano drug delivery vehicle has received considerable attention for incorporating multi-functionality, emphasizing transportation of anticancer drugs to tumour sites. Protein-based nanoparticles hold significant promise in the development of anticancer drug delivery systems since they have remarkable superiority in biocompatibility, biodegradability and natural metabolism in physiologic systems. Ionic liquids (ILs) are a class of solvents that are composed solely of ions (ILs – commonly referred as room temperature molten salts or room temperature ionic liquids). They have recently emerged as green solvents or green reaction media, because of their reported unique physico-chemical properties. We report for the first time the controlled self-assembly of Histidine Acid phosphatase (HAP) enzyme in the IL 1-butyl-3-methylimidazolium tetrafluoroborate [BMIM][BF 4 ], leading to the formation of HAP nanocapsules as template for synthesis of platinum nanospheres. These HAP nano-containers were loaded with an anticancer drug curcumin. We further demonstrated in vitro drug release and synergistic anticancer effect of these systems on three different cell lines viz. hepatocellular carcinoma (HepG2), breast cancer (MCF-7) and human acute monocytes (THP-1). The present work can extend our theoretical understanding on nano-bio interfacial molecular self assembly and will facilitate the motivated insights of inorganic/organic hybrid nano-materials/ nano-particles/ nano-objects and ionic liquids based multi functional drug delivery vehicles with synergistic combination chemotherapy for potential application in tumor targeting. INTRODUCTION During the past few decades, the design and fabrication of drug delivery vehicle has received considerable attention for incorporating multi-functionality emphasizing transportation of anticancer drugs to tumour sites. These nano drug delivery vehicles have many advantages including prolonged circulation time of the drugs (Duncan, 2003, Kiick, 2007) , improved drug targeting and solubility (Duncan, 2003, Kiick, 2007), higher payloads (Duncan, 2003) and controlled release of the therapeutics into the blood stream or the targeted tumour tissues (Uhrich et al. 1999, Duncan, 2003).

1 aSoni, Sarvesh, Kumar1 aSarkar, Sampa1 aSarkar, Dhiman1 aColoe, Peter, J.1 aBhargava, Suresh, Kumar1 aBansal, Vipul uhttps://library.ncl.res.in/content/self%E2%80%93assembled-histidine-acid-phosphate-nanocapsules-templates-multifunctional-hollow02083nas a2200253 4500008004100000022001400041245016200055210006900217260009500286300001200381490000800393520105900401653001701460653002901477653001401506653002401520653002401544653003701568100002201605700001801627700002801645700002601673856013001699 2013 eng d a0021-951700aSuzuki-Miyaura cross-coupling reaction between aryl halides and phenylboronic acids over gold nano-particles supported on MgO (or CaO) and other metal oxides0 aSuzukiMiyaura crosscoupling reaction between aryl halides and ph a525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USAbACADEMIC PRESS INC ELSEVIER SCIENCEcMAY a134-1400 v3013 a

Gold nano-particles-supported alkaline earth metal oxides, particularly MgO or CaO, show high catalytic activity in the Suzuki-Miyaura cross-coupling reaction in the presence of K2CO3 and DMF (as a solvent). The catalytic activity is strongly influenced by the nature or type of metal oxide support (viz, alkaline earth oxide, Group IIIA metal oxide, transition metal oxide, or rare earth oxide actinide oxide). It is also strongly influenced by the nature of aryl halide (aryl iodide, bromide, chloride, or fluoride), amount of K2CO3 in the reaction mixture and catalyst calcination temperature. Influence of reaction parameters viz, temperature and time and different substituents in aryl halides and/or phenylboronic acids on the biphenyl product yield in the reaction over Au/MgO catalyst has also been investigated. The catalyst showed excellent reusability in the reaction. Moreover, it is ligand-free and also has much lower cost than the commonly used homogeneous and heterogeneous Pd catalysts. (C) 2013 Elsevier Inc. All rights reserved.

10aAryl halides10aAu/MgO (or CaO) catalyst10aBiphenyls10aGold nano-particles10aphenylboronic acids10aSuzuki-Miyaura coupling reaction1 aDumbre, Deepa, K.1 aYadav, P., N.1 aBhargava, Suresh, Kumar1 aChoudhary, Vasant, R. uhttps://library.ncl.res.in/content/suzuki-miyaura-cross-coupling-reaction-between-aryl-halides-and-phenylboronic-acids-over-002046nas a2200289 4500008004100000022001400041245010700055210006900162260009500231300001200326490000800338520104400346653001301390653001201403653001801415653002201433653001101455100001701466700001801483700001601501700002001517700002201537700001901559700002801578700002001606856013001626 2016 eng d a0021-951700aStudies of synergy between metal-support interfaces and selective hydrogenation of HMF to DMF in water0 aStudies of synergy between metalsupport interfaces and selective a525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USAbACADEMIC PRESS INC ELSEVIER SCIENCEcAUG a248-2600 v3403 a

Metal-support interfaces play a very important role in heterogeneous catalysis. The interfacial interactions not only are responsible for stabilizing the necessary oxidation state to facilitate the reaction but also enhance the stability of the catalyst system. Nano dispersion of Ni on mesoporous nitrogen-rich carbon material has been achieved using two different synthesis methods. It was observed that nickel (0) gets stabilized by strong interfacial interaction with the nitrogen atoms of the support material, and the material was found to be very economic and efficient for the conversion of HMF to DMF in aqueous medium. The material shows >= 99% conversion to 5-(hydroxymethyl) furfural (HMF) within 6 h of reaction with 98.7% DMF selectivity. A unique correlation between synthesis methods and particle sizes with catalytic performance has been observed for these newly developed materials. Furthermore, a DFT calculation has been performed to predict the reaction mechanism. (C) 2016 Elsevier Inc. All rights reserved.

10abiofuels10aBiomass10aHydrogenation10amesoporous carbon10aNi-CNx1 aGoyal, Reena1 aSarkar, Bipul1 aBag, Arijit1 aSiddiqui, Nazia1 aDumbre, Deepa, K.1 aLucas, Nishita1 aBhargava, Suresh, Kumar1 aBordoloi, Ankur uhttps://library.ncl.res.in/content/studies-synergy-between-metal-support-interfaces-and-selective-hydrogenation-hmf-dmf-water