01917nas a2200229   4500008004100000022001400041245008700055210006900142260006800211300001200279490000800291520111000299653001501409653001801424653001701442653001601459100002301475700002001498700002801518700002701546856011401573       2007                        eng d  a0021-899500aDevelopment of transdermal drug-delivery films with castor-oil-based polyurethanes0 aDevelopment of transdermal drugdelivery films with castoroilbase  a111 RIVER ST, HOBOKEN, NJ 07030 USAbJOHN WILEY & SONS INCcJAN  a779-7880 v1033 a<p>Two different types of polyurethanes (PUs) were prepared with castor oil, ethylene glycol, isophorene diisocyanate and castor oil, and isophoren diisocyanate and poly(ethylene glycol) (400 or 600). PU films were prepared and characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, and gel permeation chromatography. We prepared transdermal patches by loading different amounts of drug, plasticizer, and penetration enhancer. In vitro drug permeability through the castor-oil-based aliphatic PU patches was examined with a Keshary-Chien diffusion cell. The effect of castor oil on the film-forming properties and the effect of penetration enhancers on diffusion characteristics of indomethacin (IDM) drug through the castor-oil-based PU were investigated. Prolonged release of IDM was observed from the prepared PU patches. In vitro drug diffusion revealed that slow and prolonged release of IDM was achieved in the absence of penetration enhancers. The use of penetration enhancers showed a significant effect on drug diffusion. (c) 2006 Wiley Periodicals, Inc.</p>10acastor oil10adrug delivery10apolyurethane10atransdermal1 aShelke, Namdev, B.1 aSairam, Malladi1 aHalligudi, Shivaraj, B.1 aAminabhavi, Tejraj, M.  uhttps://library.ncl.res.in/content/development-transdermal-drug-delivery-films-castor-oil-based-polyurethanes