00513nas a2200169   4500008004100000022001400041245004900055210004900104260000800153300000800161490000700169653001500176653002400191653002700215100002000242856008100262       2014                        eng d  a2053-273300aPharmaceutical solids in crystal engineering0 aPharmaceutical solids in crystal engineering  cMAY  aC120 v7010acocrystals10acrystal engineering10aSupramolecular synthon1 aNangia, Ashwini  uhttps://library.ncl.res.in/content/pharmaceutical-solids-crystal-engineering02338nas a2200157   4500008004100000022001400041245004800055210004700103260011000150300001400260490000700274520178300281100001802064700002002082856007802102       2016                        eng d  a1359-734500aPharmaceutical cocrystals: walking the talk0 aPharmaceutical cocrystals walking the talk  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcMAY  a8342-83600 v523 a<p>Pharmaceutical cocrystals belong to a sub-class of cocrystals wherein one of the components is a drug molecule (or an active pharmaceutical ingredient, API) and the second is a benign food or drug grade additive (generally regarded as safe, GRAS). The two components are hydrogen-bonded in a fixed stoichiometric ratio in the crystal lattice. In the past decade, pharmaceutical cocrystals have demonstrated significant promise in their ability to modify the physicochemical and pharmacokinetic properties of drug substances, such as the solubility and dissolution rate, bioavailability, particle morphology and size, tableting and compaction, melting point, physical form, biochemical and hydration stability, and permeability. In this feature review, we highlight some prominent examples of drug cocrystals which exhibit variable hardness/softness and elasticity/plasticity depending on coformer selection, improvement of solubility and permeability in the same cocrystal, increase of the melting point for solid formulation, enhanced color performance, photostability and hydration stability, and a longer half-life. Cocrystals of flavanoids and polyphenols can make improved pharmaceuticals and also extend to the larger class of nutraceuticals. The application of crystal engineering to assemble ternary cocrystals expands this field to drug-drug cocrystals which may be useful in multi-drug resistance, mitigating side effects of drugs, or attenuating/enhancing drug action synergistically by rational selection. The advent of new techniques for structural characterization beyond the standard X-ray diffraction will provide a better understanding of drug phases which are at the borderline of crystalline-amorphous nature and even newer opportunities in the future.</p>1 aBolla, Geetha1 aNangia, Ashwini  uhttps://library.ncl.res.in/content/pharmaceutical-cocrystals-walking-talk01885nas a2200181   4500008004100000022001400041245008900055210006900144260000900213300001200222490000700234520125200241100002001493700002801513700002201541700002001563856012001583       2017                        eng d  a1466-803300aPolymorphism, isostructurality and physicochemical properties of glibenclamide salts0 aPolymorphism isostructurality and physicochemical properties of   cFEB   a918-9290 v193 a<p>Novel salts of glibenclamide (GBA), namely glibenclamide-sodium (GBA-Na), glibenclamide-potassium (GBA-K) and glibenclamide-ammonium (GBA-NH4) were crystallized under different conditions to obtain their polymorphs, and their aqueous solubility and hydration stability studies are reported. The GBA-Na salt is dimorphic (forms I and II)and also exists as hydrate GBA-Na-H2O (form III). The GBA-K salt exists in anhydrous and hydrate forms (GBA-K, forms I and II). Crystal structure analysis of GBA-Na forms I and II showed differences in geometry of the central metal atom and ligand orientation. This kind of polymorphism of sulfonyl urea salts appears to be novel in the Cambridge Structural Database (CSD). The iso-structurality of GBA-Na form I with GBA-NH4 and GBA-K form I salts is discussed. The potassium salts of GBA exhibited higher solubility compared to pure GBA. Specifically GBA-K salt forms I and II showed higher solubility by 77 fold in the water and 33 fold in phosphate buffer (pH 7) compared to the other salts. Dynamic vapor sorption (DVS) showed reversible water sorption without hysteresis for all salts, except for GBA-K form II which transformed to form I after a sorption and desorption cycle as confirmed by PXRD.</p>1 aSuresh, Kuthuru1 aKhandavilli, U., B. Rao1 aGunnam, Anilkumar1 aNangia, Ashwini  uhttps://library.ncl.res.in/content/polymorphism-isostructurality-and-physicochemical-properties-glibenclamide-salts