02199nas a2200253   4500008004100000022001400041245013800055210006900193260007500262300001400337490000700351520123200358653001601590653002001606653001901626653003001645653002701675100002301702700002301725700002101748700002701769700002401796856012501820       2013                        eng d  a0724-874100aMapping ion-induced mesophasic transformation in lyotropic in situ gelling system and its correlation with pharmaceutical performance0 aMapping ioninduced mesophasic transformation in lyotropic in sit  a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGER/PLENUM PUBLISHERScJUL  a1906-19140 v303 a<p>To investigate influence of ion induced mesophasic transformation on pharmaceutical performance of in situ gelling system consisting of glyceryl monooleate. The prepared system showed mesophasic transformation during its conversion from sol to gel upon controlled hydration. The process of mesophasic transformation was studied by SAXS, DSC, rheology and plane polarized light microscopy. Further the influence of additives i.e. naproxen salts (sodium and potassium) and naproxen (base) on the process of mesophasic transformation was also elucidated. It was observed that addition of salt form of naproxen transformed W/O emulsions into cubic mesophase whereas addition of base form of naproxen formed reverse hexagonal (H-II) phase upon controlled hydration. The cubic mesophase formed by naproxen salts retarded the drug release for initial 3 h whereas H-II phase showed sustained drug release characteristics for naproxen base following Higuchi drug release kinetics. The current work suggests that formulations with tailor made pharmaceutical performance can be developed by selecting proper additives in the system so as to obtain the desired mesophase `on demand' thereby controlling drug release characteristics.</p>10acubic phase10ahexagonal phase10aliquid crystal10amesophasic transformation10asustained drug release1 aPatil, Sharvil, S.1 aVenugopal, Edakkal1 aBhat, Suresh, K.1 aMahadik, Kakasaheb, R.1 aParadkar, Anant, R.  uhttps://library.ncl.res.in/content/mapping-ion-induced-mesophasic-transformation-lyotropic-situ-gelling-system-and-its-002187nas a2200265   4500008004100000022001400041245015300055210006900208260005700277300001400334490000700348520121000355653001701565653002001582653001401602653001501616653001901631653002701650100002301677700002301700700002101723700002701744700002401771856012601795       2015                        eng d  a1530-993200aExploring microstructural changes in structural analogues of ibuprofen-hosted in situ gelling system and its influence on pharmaceutical performance0 aExploring microstructural changes in structural analogues of ibu  a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGERcOCT  a1153-11590 v163 a<p>The present work explores inner structuration of in situ gelling system consisting of glyceryl monooleate (GMO) and oleic acid (OA). The system under study involves investigation of microstructural changes which are believed to govern the pharmaceutical performance of final formulation. The changes which are often termed mesophasic transformation were analysed by small angle Xray scattering (SAXS), differential scanning calorimetry (DSC), rheology and plane polarised light (PPL) microscopy. The current work revealed transformation of blank system from W/O emulsion to reverse hexagonal structure upon addition of structural analogues of ibuprofen. Such transformations are believed to occur due to increased hydrophobic volume within system as probed by SAXS analysis. The findings of SAXS studies were well supported by DSC, rheology and PPL microscopy. The study established inverse relationship between log P value of structural analogues of ibuprofen and the degree of binding of water molecules to surfactant chains. Such relationship had pronounced effect on sol-gel transformation process. The prepared in situ gelling system showed sustained drug release which followed Higuchi model.</p>10aflurbiprofen10ahexagonal phase10aibuprofen10aketoprofen10aliquid crystal10asustained drug release1 aPatil, Sharvil, S.1 aVenugopal, Edakkal1 aBhat, Suresh, K.1 aMahadik, Kakasaheb, R.1 aParadkar, Anant, R.  uhttps://library.ncl.res.in/content/exploring-microstructural-changes-structural-analogues-ibuprofen-hosted-situ-gelling-0