02420nas a2200277   4500008004100000022001400041245008900055210006900144260007500213300001400288490000700302520146100309653001301770653001701783653001401800653001501814653002301829653002801852653002501880100002301905700002301928700002101951700002701972700002401999856011902023       2012                        eng d  a0724-874100aMicrostructural elucidation of self-emulsifying system: effect of chemical structure0 aMicrostructural elucidation of selfemulsifying system effect of   a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGER/PLENUM PUBLISHERScAUG  a2180-21880 v293 a<p>Self-emulsifying systems (SES) emulsify spontaneously to produce fine oil-in-water emulsion when introduced into aqueous phase. The self-emulsification process plays an important role during formation of emulsion. The objective of current work was to understand and explore the inner structuration of SES through controlled hydration and further to study the influence of additive on the same which ultimately governs performance of final formulation in terms of droplet size. Droplet size of final formulations containing structural analogues of ibuprofen was determined. Microstructural properties of intermediate hydrated regimes of SES were investigated using techniques such as small angle X-ray scattering, differential scanning calorimetry and rheology. The current work established inverse relationship between droplet size of the formulations containing structural analogues of ibuprofen and their Log P values. Microstructural analysis of intermediate hydrated regimes of the prepared samples showed formation of local lamellar structure. Structural analogues of ibuprofen significantly altered microstructure of lamellae which was well correlated with the droplet size of final formulations. In vitro drug release study showed increase in dissolution rate of lipophillic drugs when formulated as SES. The current work emphasizes the fact that tailor-made formulations can be prepared by controlling the properties of intermediate regimes.</p>10aemulsion10aflurbiprofen10aibuprofen10aketoprofen10alamellar structure10aself-emulsifying system10astructural analogues1 aPatil, Sharvil, S.1 aVenugopal, Edakkal1 aBhat, Suresh, K.1 aMahadik, Kakasaheb, R.1 aParadkar, Anant, R.  uhttps://library.ncl.res.in/content/microstructural-elucidation-self-emulsifying-system-effect-chemical-structure-002187nas a2200265   4500008004100000022001400041245015300055210006900208260005700277300001400334490000700348520121000355653001701565653002001582653001401602653001501616653001901631653002701650100002301677700002301700700002101723700002701744700002401771856012601795       2015                        eng d  a1530-993200aExploring microstructural changes in structural analogues of ibuprofen-hosted in situ gelling system and its influence on pharmaceutical performance0 aExploring microstructural changes in structural analogues of ibu  a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGERcOCT  a1153-11590 v163 a<p>The present work explores inner structuration of in situ gelling system consisting of glyceryl monooleate (GMO) and oleic acid (OA). The system under study involves investigation of microstructural changes which are believed to govern the pharmaceutical performance of final formulation. The changes which are often termed mesophasic transformation were analysed by small angle Xray scattering (SAXS), differential scanning calorimetry (DSC), rheology and plane polarised light (PPL) microscopy. The current work revealed transformation of blank system from W/O emulsion to reverse hexagonal structure upon addition of structural analogues of ibuprofen. Such transformations are believed to occur due to increased hydrophobic volume within system as probed by SAXS analysis. The findings of SAXS studies were well supported by DSC, rheology and PPL microscopy. The study established inverse relationship between log P value of structural analogues of ibuprofen and the degree of binding of water molecules to surfactant chains. Such relationship had pronounced effect on sol-gel transformation process. The prepared in situ gelling system showed sustained drug release which followed Higuchi model.</p>10aflurbiprofen10ahexagonal phase10aibuprofen10aketoprofen10aliquid crystal10asustained drug release1 aPatil, Sharvil, S.1 aVenugopal, Edakkal1 aBhat, Suresh, K.1 aMahadik, Kakasaheb, R.1 aParadkar, Anant, R.  uhttps://library.ncl.res.in/content/exploring-microstructural-changes-structural-analogues-ibuprofen-hosted-situ-gelling-0