02439nas a2200205   4500008004100000245008700041210006900128260000800197490000700205520173800212100002001950700002001970700001801990700002502008700002402033700001502057700001702072700002502089856011902114       2015                        eng d00aAssociation between serum albumin and glycated hemoglobin in Asian Indian subjects0 aAssociation between serum albumin and glycated hemoglobin in Asi  cJAN0 v193 a<p>Protein glycation plays a significant role in diabetic complications. Glycated hemoglobin (HbA1c) is a known predictor of diabetes and its complications. Albumin, found to be profoundly glycated in diabetes, and its level could regulate plasma protein as well as hemoglobin glycation. We aimed to evaluate the association between variations in albumin level with HbA1c in the Asian Indian population. We screened data of 929 subjects who have had a simultaneous measurement of fasting plasma glucose (FPG), HbA1c and albumin levels via the same blood collection. Data were analyzed by SPSS for 610 subjects who met the study criteria. There was a significant negative correlation between HbA1c and albumin concentration (r = -0.284; P &lt; 0.001). Univariate analysis showed the statistically significant decrease of average HbA1c but not for fasting plasma glucose (FPG) across increasing tertiles of albumin. Stepwise multiple regression model showed a significant correlation between HbA1c and serum albumin (P &lt; 0.05), FPG (P &lt; 0.001), hemoglobin (Hb) (P &lt; 0.001) and serum globulin (P &lt; 0.05). FPG was the strongest predictor (63.4%) of variation of HbA1c. The albumin concentration (r = -0.114) accounted for 0.3% (P &lt; 0.05) of the total variance in HbA1c independent of age, body mass index, FPG, Hb, creatinine, total protein and globulin. It was also observed that HbA1c decreases with increasing albumin concentration in those having FPG between 100 to &lt;126 mg/dl. Serum albumin negatively correlates with HbA1c in Asian Indians independent of other variables. This study suggests that predicting diabetes and its complication based on the HbA1c needs to be further investigated in Indian subjects.</p>1 aTiwari, Shalbha1 aBotahle, Manish1 aHasan, Imtiaz1 aKulkarni, Mahesh, J.1 aSayyad, Mehmood, G.1 aBasu, Rita1 aBasu, Ananda1 aG., Unnikrishnan, A.  uhttps://library.ncl.res.in/content/association-between-serum-albumin-and-glycated-hemoglobin-asian-indian-subjects01638nas a2200265   4500008004100000022001400041245014600055210007000201260000800271300001400279490000700293520073700300653000801037653002001045653001301065653001401078653002001092653000801112100002401120700002001144700002801164700002501192700002501217856013001242       2025                        eng d  a0973-393000aAutoantibodies against Nε-carboxymethyl lysine and methylglyoxal modified albumin are associated with cardiovascular risk in type 2 diabetes0 aAutoantibodies against Nεcarboxymethyl lysine and methylglyoxal   cDEC  a1104-11100 v453 a<p>
	{Background Albumin is an abundant plasma protein which gets modified with advanced glycation end products (AGEs) predominantly in diabetic condition. AGE modification induces immune response and autoantibodies are generated which play an important role in disease pathology. Objective This study aimed to illustrate the role of autoantibodies against N epsilon-carboxymethyl lysine (CML) and methylglyoxal (MG) modified albumin in diabetic cardiovascular complications. MethodsType-2 diabetes subjects were enrolled and further grouped into stress test positive or stress test negative based on treadmill stress test (TMT). Autoantibody titer was quantified by ELISA assay for CML-modified albumin (stress test positive</p>
10aAGE10aAtherosclerosis10aDiabetes10aGlycation10aImmune response10aROC1 aPatil, Yugendra, R.1 aTiwari, Shalbha1 aMomin, Abdulrahaman, A.1 aUnnikrishnan, A., G.1 aKulkarni, Mahesh, J.  uhttps://library.ncl.res.in/content/autoantibodies-against-n%CE%B5-carboxymethyl-lysine-and-methylglyoxal-modified-albumin-are