02285nas a2200253   4500008004100000022001400041245013700055210006900192260007900261300001200340490000800352520132400360653001701684653002301701653003001724653002401754653001401778100002001792700002501812700002601837700002401863700002101887856012301908       2016                        eng d  a0273-228900aAntioxidative metabolites synthesized by marine pigmented vibrio sp and its protection on oxidative deterioration of membrane lipids0 aAntioxidative metabolites synthesized by marine pigmented vibrio  a999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USAbHUMANA PRESS INCcAPR  a155-1670 v1793 a<p>Bacterial strain Vibrio sp. (PIGB 184) isolated from water samples of the Arabian Sea and identified through 16S rRNA demonstrated the production of pigmentary antioxidants with higher ABTS activities 90.9 +/- 0.42 % in comparison with the standard commercial pigmented antioxidant, quercetin 88.8 +/- 1.4 %. Antioxidative metabolites of this strain substantially inhibit the lipid peroxidation (LPO) reactions tested in sheep liver and brain. The antioxidant compounds produced by the Vibrio sp. (PIGB 184), analysed by GC-MS, reveals that it is composed mostly of phenol, 2,4-bis(1,1-dimethylethyl) and pyrrolo[1,2-a]pyrazine-1,4-dione,hexahydro-3-(2-methylpropyl). The interrelationship assessed between LPO and the phenolic compounds showed significant correlation with anti-LPO properties (R (2) = 0.9698 to 0.9861). These compounds are responsible for obstruction of harmful radical associated biochemical reactions in biological systems. Pigmented metabolites also tested for attributive biological properties against pathogenic bacteria showed prominent inhibition towards Gram-positive organisms (31.25 to 62.5 mu g ml(-1)). From this study, it may be suggested that the marine bacterium PIGB 184 could be used as a potential bio-resource for antioxidants and needs to be worked out for mass production.</p>10aAntioxidants10aLipid peroxidation10aMarine pigmented bacteria10aPathogen inhibition10aPhenolics1 aPawar, Ravindra1 aMohandass, Chellandi1 aDastager, Syed, Gulam1 aKolekar, Yogesh, M.1 aMalwankar, Rahul  uhttps://library.ncl.res.in/content/antioxidative-metabolites-synthesized-marine-pigmented-vibrio-sp-and-its-protection